Development and validation of the ISARIC 4 C

Development and validation of the ISARIC 4 C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study Rishi K Gupta, MRCP, Prof Ewen M Harrison, Ph. D, Antonia Ho, Ph. D, Annemarie B Docherty, Ph. D, Stephen R Knight, MBCh. B, Maarten van Smeden, Ph. D, Prof Ibrahim Abubakar, FRCP, Prof Marc Lipman, MD, Matteo Quartagno, Ph. D, Riinu Pius, Ph. D, Prof Iain Buchan, FFPH, Gail Carson, MRCP, Thomas M Drake, MBCh. B, Jake Dunning, Ph. D, Cameron J Fairfield, MBCh. B, Prof Carrol Gamble, Ph. D, Christopher A Green, DPhil, Sophie Halpin, Hayley E Hardwick, Karl A Holden, MBCh. B, Prof Peter W Horby, FRCP, Clare Jackson, Kenneth A Mclean, MBCh. B, Laura Merson, BSc, Prof Jonathan S Nguyen-Van-Tam, DM, Lisa Norman, Ph. D, Prof Piero L Olliaro, Ph. D, Mark G Pritchard, MBCh. B, Clark D Russell, MBCh. B, James Scott-Brown, DPhil, Catherine A Shaw, CAS, Prof Aziz Sheikh, MD, Prof Tom Solomon, FRCP, Prof Cathie Sudlow, FRCP[E], Olivia V Swann, Ph. D, Lance Turtle, Ph. D, Prof Peter J M Openshaw, J Kenneth Baillie, Ph. D, Prof Malcolm G Semple, Ph. D, Prof Mahdad Noursadeghi, Ph. D J Kenneth Baillie, Malcolm G Semple, Peter JM Openshaw, Gail Carson, Beatrice Alex, Benjamin Bach, Wendy S Barclay, Debby Bogaert, Meera Chand, Graham S Cooke, Annemarie B Docherty, Jake Dunning, Ana da Silva Filipe, Tom Fletcher, Christopher A Green, Ewen M Harrison, Julian A Hiscox, Antonia Ying Wai Ho, Peter W Horby, Samreen Ijaz, Saye Khoo, Paul Klenerman, Andrew Law, Wei Shen Lim, Alexander J Mentzer, Laura Merson, Alison M Meynert, Mahdad Noursadeghi, Shona C Moore, Massimo Palmarini, William A Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L Robertson, Clark D Russell, Vanessa Sancho-Shimizu, Janet T Scott, Thushan de Silva, Louise Sigfrid, Tom Solomon, Shiranee Sriskandan, David Stuart, Charlotte Summers, Richard S Tedder, Emma C Thomson, AA Roger Thompson, Ryan S Thwaites, Lance CW Turtle, Maria Zambon, Hayley Hardwick, Chloe Donohue, Ruth Lyons, Fiona Griffiths, Wilna Oosthuyzen, Lisa Norman, Riinu Pius, Tom M Drake, Cameron J Fairfield, Stephen Knight, Kenneth A Mclean, Derek Murphy, Catherine A Shaw, Jo Dalton, James Lee, Daniel Plotkin, Michelle Girvan, Scott Mullaney, Claire Petersen, Egle Saviciute, Stephanie Roberts, Janet Harrison, Laura Marsh, Marie Connor, Sophie Halpin, Clare Jackson, Carrol Gamble, Gary Leeming, Andrew Law, Murray Wham, Sara Clohisey, Ross Hendry, James Scott-Brown, William Greenhalf, Victoria Shaw, Sarah Mc. Donald, Seán Keating, Katie A. Ahmed, Jane A Armstrong, Milton Ashworth, Innocent G Asiimwe, Siddharth Bakshi, Samantha L Barlow, Laura Booth, Benjamin Brennan, Katie Bullock, Benjamin WA Catterall, Jordan J Clark, Emily A Clarke, Sarah Cole, Louise Cooper, Helen Cox, Christopher Davis, Oslem Dincarslan, Chris Dunn, Philip Dyer, Angela Elliott, Anthony Evans, Lorna Finch, Lewis WS Fisher, Terry Foster, Isabel Garcia-Dorival, Willliam Greenhalf, Philip Gunning, Catherine Hartley, Antonia Ho, Rebecca L Jensen, Christopher B Jones, Trevor R Jones, Shadia Khandaker, Katharine King, Robyn T. Kiy, Chrysa Koukorava, Annette Lake, Suzannah Lant, Diane Latawiec, L Lavelle-Langham, Daniella Lefteri, Lauren Lett, Lucia A Livoti, Maria Mancini, Sarah Mc. Donald, Laurence Mc. Evoy, John Mc. Lauchlan, Soeren Metelmann, Nahida S Miah, Joanna Middleton, Joyce Mitchell, Shona C Moore, Ellen G Murphy, Rebekah Penrice-Randal, Jack Pilgrim, Tessa Prince, Will Reynolds, P. Matthew Ridley, © 2021 The Author(s). Published Elsevier. Benjamin Ltd. This is. Small, an Open. Krishanthi Access article under the CC Debby Copyright Sales, Victoria E Shaw, Rebecca K by Shears, S Subramaniam, Agnieska Szemiel, Aislynn Taggart, BY 4. 0 license Terms and Conditions

Figure 1 The Lancet Respiratory Medicine 2021 9349 -359 DOI: (10. 1016/S 2213 -2600(20)30559 -2) Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions

Figure 2 The Lancet Respiratory Medicine 2021 9349 -359 DOI: (10. 1016/S 2213 -2600(20)30559 -2) Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions

Figure 3 The Lancet Respiratory Medicine 2021 9349 -359 DOI: (10. 1016/S 2213 -2600(20)30559 -2) Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions

Figure 4 The Lancet Respiratory Medicine 2021 9349 -359 DOI: (10. 1016/S 2213 -2600(20)30559 -2) Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4. 0 license Terms and Conditions