Developing Research Proposal Systematic Review Mohammed TA Omar
- Slides: 22
Developing Research Proposal Systematic Review Mohammed TA, Omar Ph. D. PT Rehabilitation Health Science
What is a systematic Review ? • A systematic review is defined as “a review of the evidence on a clearly formulated question that uses systematic and explicit methods to identify, select and critically appraise relevant primary research, and to extract and synthesis, analyze data from the studies that are included in the review. ”
Why ? The problems are that … • Too much information, too little time • Many too poorly done or insufficiently relevant to be clinically useful • Many have conflicting results • On top of these, high quality information is often not easy to find 3
Why do systematic reviews? • Support Evidence Based Practice • Research • Inform clinical policy • Publication • Personal professional development
Systematic reviews are the same as narrative reviews
Types of Systematic Review Intervention • To assess the evidence about the effects of a healthcare intervention. Prognostics • To assess the evidence about the effects of a healthcare intervention Measurement • To assess the properties of health-status instruments or tools
Stages of Systematic Review Formulate research question Further selection of primary studies using inclusion criteria Extract data Search bibliographic databases Design search strategy/plan Retrieve papers Identify possible papers from titles/abstracts Quality Synthesi appraisal s Formulate research / policy conclusions
Formulate Research Question PICO • What types of • The first and most important decision in preparing a review is to determine its focus Participants? Interventions? Comparison? • This is best done by asking Outcomes? clearly framed questions.
Formulation of a intervention question • Does low level laser therapy effective in treatment of diabetic foot ulcer? In patients with Chronic Diabetic Foot Ulcer (DFU), does low level laser therapy lead to higher rates of healing as compared to standardized wound care?
Design Research Strategy/Plan Your development plan should include: 1. Your clinical question 2. Criteria for the literature search Key words Databases Dates to include (how far back do you go? ) 3. Inclusion and exclusion criteria Types of studies design Types of participants Types of intervention Type of outcome measurements 4. A timeline for your project
Key Words • Key Text words for the condition, e. g. , • ‘Foot ulcer' , 'diabetic foot ulcer' , 'diabetic wound', 'diabetic complications' • Key Text words for the intervention, e. g. , • • Low level Laser Therapy Low Power Laser Low Energy Laser Bio-stimulation Dates to include (how far back do you go? ) Ø Time of the fist review (if possible) Ø No systematic review before ( back for 10 years)
Data sources for a systematic review • Electronic databases • MEDLINE and EMBASE • Specialized or local databases (CINAHL, CENTRAL, AMED, …) • Hand searching • “Grey literature” ( thesis, Internal reports, pharmaceutical industry files) • Checking reference lists • Unpublished sources known to experts in the specialty (seek by personal communication) • Raw data from published trials 12
• Parameters • Comparison to other intervention • Placebo • Sham Outcomes • sex • Age • Conditions Intervention • RCT • Case control • Cohort study Participants Study designs Criteria • Primary • Secondary
Exercises: As group carful read the following paper and selected the following • Research questions • Keywords • Date of search • Language of search • Types of data base • Criteria of search
Study Timeline Project Tasks 1. Project Development Plan 2. Perform Literature Search 3. Inclusion/exclusion of Articles 4. Table of Evidence/Data Extraction 5. Table of Evidence Review 6. First Draft of Review 7. Committee Review 8. External Review Timeline
Synthesis and Critical Appraisal • Data Extraction (draw diagram ) • Create Tables of Evidence • Methodological Quality
Data extraction flow chart
Create Tables of Evidence Most common approaches to classification and grading of the evidence • Sackett 's 5 levels of evidence • Oxford Centre for Evidence-Based Medicine levels of evidence
Methodological Quality: Jadad Scale JADAD SCAL Criteria Score 1 a. Was the study described as randomized? +1 1 b. Was the method of randomization described and appropriate to conceal allocation? +1 1 c. If described and inappropriate, describe: 2 a. Was the study described as double blinded? 2 b. Was the method of double-blinding described and appropriate to maintain a double-blinding? 2 c. Was the method of blinding inappropriate? -1 3. Was there a description of withdrawals and drop outs? Total (0 -5) +1 +1 =1 -1 5
Methodological Quality: PEDro. Scale
Methodological Quality: Van Tulder
Systematic Review to User Product Using the synthesis of evidence resulting from you review What would you take as a next step for each of the following audiences • CLINICIANS • RESEARCHERS • CONSUMERS
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