Departamento de Imunologia Instituto de Cincias Biomdicas Universidade

Departamento de Imunologia Instituto de Ciências Biomédicas Universidade de São Paulo Imunidade Inata: Mecanismos Efetores Dr. Antonio Condino Neto Professor Associado Livre-Docente

Imunidade Inata x Imunidade Adaptativa Figure 2 -1

Figure 2 -2 part 1 of 2

Figure 2 -2 part 2 of 2

Exemplo de Resposta à Infecção Figure 2 -3

Figure 2 -4

Figure 2 -5 part 1 of 2

Figure 2 -5 part 2 of 2

Fagocitose Figure 2 -6

NADPH-Oxidase Gene Cromossomo Frequência (%) gp 91 -phox Xp 21. 1 67 p 22 -phox 16 q 24 5 p 47 -phox 7 q 11. 23 33 p 67 -phox 1 q 25 5 G 6 PD Xq 28 <0. 01 Adaptado de Curnutte et al, 2002

Figure 2 -8 part 1 of 2

Figure 2 -8 part 2 of 2

Figure 2 -9

Figure 2 -10

Figure 2 -11

Figure 2 -12

TLR Ligands - Recognition PAMPS TLR Ligand Source TLR 1/2 lipoarabinomanin mycobacteria TLR 2± 6 Zymosan Fungi TLR 3 DS RNA Viruses TLR 4 lipopolysaccharide Peptidoglycan RSV fusion protein Gr- bacteria Gr+ bacteria RSV TLR 5 Flagellin Flagelated bacteria TLR 6/2 Diacyl lipopeptides Mycoplasma TLR 7 and 8 SS RNA Imidazoquinolones Viruses Synthetic TLR 9 Cp. G Bacteria and DNA viruses TLR 10 Unknown

Figure 2 -13

TLR signal generation to NF- B after ligation TLR 5/10/11 TLR 2 Cell membrane TLR 7/8/9 TLR 1/6 CD 14 TIRAP TLR 4 MD 2 TIRAP TLR 3 My. D 88 Endosome My. D 88 IRAK 4 TRAF 6 TRIF RIP 1 My. D 88 NEMO IKK- p I B Cytoplasm Nucleus NF- B binding motif New gene transcription

TLR induction of other transcription factors TLR 5/10/11 Cell membrane TLR 7/8/9 TLR 2 TLR 1/6 CD 14 TIRAP TLR 4 MD 2 TRAM My. D 88 Endosome My. D 88 TRIF TLR 3 TRIF My. D 88 IRF 7 IRAK 1/4 TRAF 6 IRF 5 IRAK 4 TRAF 6 TBK 1 MAPK Cytoplasm Nucleus AP-1 IRF 3 New gene transcription