DCE SMART Team 20112012 The Bubonic Plague By
DCE SMART Team 20112012: The Bubonic Plague By Zach Peterson and Matt Gargulak Mentor: MSOE CBM Dr. Colton
What is SMART? - Students Modeling A Research Topic Organize groups Research the topic Write an abstract Use Jmol to recreate biomolecular structure http: //upload. w ikimedia. org/wi kipedia/comm ons/b/b 0/Jmol _logo. jpg
History of the Bubonic Plague - Plague of Justinian (500 s) - First recorded epidemic - Black Death (1347) - Major outbreak in Europe - Treatment - Eat well, rest, and leave infected areas Biological Warfare - 14 th century armies used bubonic plague to their advantage
http: //upload. wikimedia. org/wikipedia/commons/1/1 b/Bubonic_plague_victims-mass_grave_in_Martigues%2 C_France_1720 -1721. jpg
Importance of the Bubonic Plague - Common in rats Transmitted through fleas to humans - Extremely contagious - Fast-acting - Had no cure http: //upload. wikimedia. org /wikipedia/commons/d/d 0/Y ersinia_pestis. jpghttp: //uplo ad. wikimedia. org/wikipedia/ commons/d/d 0/Yersinia_pest is. jpg http: //upload. wikimedia. org /wikipedia/commons/c/c 1/F lea_infected_with_yersinia_p estis. jpg
Surface Protein - Pla Gram-negative bacteria Attaches to cell walls in the lymph nodes - Attracts Plasminogen activator inhibitors (PAI) into negative pocket Breaks peptide bonds http: //micro. digitalpr oteus. com/pics/gra mbacterium. jpg
Yersinia Pestis (Scientific Name) - Most commonly caused by the bite of an infected rodent or parasite Rarely transmitted by human contact Common in unsanitary rural areas Oftentimes fatal http: //www. rkm. com. au/imag elibrary/thumbnails/Yersinia 1 50. jpg
Yersinia Pestis (Scientific Name) - Comes in three forms - Bubonic (Lymphatic) - Pneumonic (Respiratory) - Septicemic (Circulatory) http: //s 2. hubimg. com/u/1498965_f 260. jpg http: //people. uwec. edu/pie rcech/bio/Pict ures/plague 3. gif
Symptoms (Bubonic Plague) - Gangrene Chills High fever Muscle cramps Seizures Swollen lymph glands Skin discoloration Bleeding of the ears http: //rlv. zcache. com/main_symptoms_of_black_death_bu bonic_plague_chart_posterr 7976 f 470 e 1824 a 8 eb 1 fbe 096 a 5 b 00 c 6 f_azzc 8_400. jpg
Why is it less common today? - Increase in overall hygiene - Decrease in infected organisms - Change in climate - (1: 56 -2: 58) http: //www. youtube. com/watch? v=p. RZYb 2 Jl 22 g
- Slides: 11