Cytologic features Scattered isolated large atypical cells with

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Cytologic features • Scattered isolated large atypical cells, with irregular nuclear contours, vesicular chromatin,

Cytologic features • Scattered isolated large atypical cells, with irregular nuclear contours, vesicular chromatin, prominent nucleoli, scant or absent cytoplasm, mitosis, & apoptosis • Inflammatory cells in the background • No squamous or gladular lesions

Differential diagnosis • • Follicular cervicitis/chronic cervicitis Small cell squamous carcinoma Small cell neuroendocrine

Differential diagnosis • • Follicular cervicitis/chronic cervicitis Small cell squamous carcinoma Small cell neuroendocrine carcinoma Endometrial stromal sarcoma Malignant melanoma Adenocarcinoma, primary or metastatic Ewing sarcoma/PNET Hematologic malignancy

Cytokeratin (AE 1/AE 3) Leukocyte common antigen

Cytokeratin (AE 1/AE 3) Leukocyte common antigen

Diagnosis Uterus, cervix, Pap smear: Malignant lymphoma

Diagnosis Uterus, cervix, Pap smear: Malignant lymphoma

Uterus, endometrium, curettage

Uterus, endometrium, curettage

H&E CD 20 CD 3

H&E CD 20 CD 3

Discussion • Less than 1% of extranodal lymphomas arise from gynecologic tract. 7~30% of

Discussion • Less than 1% of extranodal lymphomas arise from gynecologic tract. 7~30% of secondary involvement. • 23~30% sensitivity of conventional Pap smear • More challenging on liquid preparations

Hyperchromatic cells with high N/C ratio on Pap smear 1. Long list of differential

Hyperchromatic cells with high N/C ratio on Pap smear 1. Long list of differential diagnosis benign/reactive, preneoplastic, and neoplastic process 2. Careful systematic evaluation of squamous and glandular elements as well as the background component 3. Correlation with clinical history and radiological findings

Cytologic features Clusters many large or 50 cellsCytologic features Clusters many large or 50 cells
CYTOLOGIC INDICES o The cytologic assessment of hormonalCYTOLOGIC INDICES o The cytologic assessment of hormonal
Cytologic Findings Cellularity moderate p Individually scattered orCytologic Findings Cellularity moderate p Individually scattered or
Atypical cytoplasm Pathologic Findings Atypical cells single orAtypical cytoplasm Pathologic Findings Atypical cells single or
SCATTERED DATA VISUALIZATION Yingcai Xiao Scattered Data sampleSCATTERED DATA VISUALIZATION Yingcai Xiao Scattered Data sample
Cytologic features Cohesive cell clusters medium to largeCytologic features Cohesive cell clusters medium to large
Cytologic features Clean background Clusters and single cellsCytologic features Clean background Clusters and single cells
Chapter 16 Atypical Sexual Behavior What Constitutes AtypicalChapter 16 Atypical Sexual Behavior What Constitutes Atypical
Atypical wounds Atypical Wound Wounds due to uncommonAtypical wounds Atypical Wound Wounds due to uncommon
Atypical Behaviour What makes a phobia atypical behaviourAtypical Behaviour What makes a phobia atypical behaviour
IBD Isolated terminal ileitis Atypical UC Amoebic colitisIBD Isolated terminal ileitis Atypical UC Amoebic colitis
Cytologic features Background Proteinaceous fluid with many hemosiderinCytologic features Background Proteinaceous fluid with many hemosiderin
Cytologic features Relatively hypocellular smear Dispersed and looselyCytologic features Relatively hypocellular smear Dispersed and loosely
Cytologic features Background Necrotic tumor diathesis Cellularity ModerateCytologic features Background Necrotic tumor diathesis Cellularity Moderate