Cytogenetic profiles in multiple myeloma and monoclonal gammopathy

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Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in

Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells by Martin Schmidt-Hieber, María Laura Gutiérrez, Martin Pérez-Andrés, Bruno Paiva, Ana Rasillo, Maria Dolores Tabernero, José Maria Sayagués, Antonio Lopez, Paloma Bárcena, María Luz Sanchez, Norma C. Gutiérrez, Jesus F. San Miguel, and Alberto Orfao haematol Volume 98(2): 279 -287 January 31, 2013 © 2013 by Ferrata Storti Foundation

Illustrating examples of clonal profiles of MM patients found by i. FISH analysis of

Illustrating examples of clonal profiles of MM patients found by i. FISH analysis of highly purified a. PC, as defined in Table 2. Martin Schmidt-Hieber et al. Haematologica 2013; 98: 279287 © 2013 by Ferrata Storti Foundation

Frequency of individual cytogenetic alterations in MM and MGUS. Martin Schmidt-Hieber et al. Haematologica

Frequency of individual cytogenetic alterations in MM and MGUS. Martin Schmidt-Hieber et al. Haematologica 2013; 98: 279287 © 2013 by Ferrata Storti Foundation

Cytogenetic patterns defined by the simultaneous assessment of del(13 q 14), del(17 p 13),

Cytogenetic patterns defined by the simultaneous assessment of del(13 q 14), del(17 p 13), +17 p 13 and t(14 q 32) in different cytogenetic subgroups of patients with MM or MGUS. Martin Schmidt-Hieber et al. Haematologica 2013; 98: 279287 © 2013 by Ferrata Storti Foundation

Percentage of highly purified a. PC with del(13 q 14), +17 p 13, del(17

Percentage of highly purified a. PC with del(13 q 14), +17 p 13, del(17 p 13), t(14 q 32) and del(14 q 32)/+14 q 32 in the absence of t(14 q 32) from all bone marrow a. PC in individual MM versus MGUS patients. Martin Schmidt-Hieber et al. Haematologica 2013; 98: 279287 © 2013 by Ferrata Storti Foundation

Number of cytogenetically different clones in the distinct cytogenetic groups of MM versus MGUS

Number of cytogenetically different clones in the distinct cytogenetic groups of MM versus MGUS patients. Martin Schmidt-Hieber et al. Haematologica 2013; 98: 279287 © 2013 by Ferrata Storti Foundation

Sequence of acquisition of cytogenetic alterations - del(13 q 14), del(17 p 13) and

Sequence of acquisition of cytogenetic alterations - del(13 q 14), del(17 p 13) and t(14 q 32) -and frequency of clonal profiles in MM (A) and MGUS (B). Martin Schmidt-Hieber et al. Haematologica 2013; 98: 279287 © 2013 by Ferrata Storti Foundation

Simultaneous analysis of cy. Igκ light chain expression (diffuse red staining) and i. FISH

Simultaneous analysis of cy. Igκ light chain expression (diffuse red staining) and i. FISH spots for the IGH dual color break apart probe in purified a. PC from a representative MM patient carrying t(4; 14) in only part of all a. PC. Martin Schmidt-Hieber et al. Haematologica 2013; 98: 279287 © 2013 by Ferrata Storti Foundation

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