CYP 1 B 1 cytochrome P 450 family

CYP 1 B 1 - cytochrome P 450, family 1, subfamily B, polypeptide 1

График Км • Efficiency of CYP 1 B 1 activity demonstrated by (A) Michaelis–Menten and (B) Linneweaver–Burke plots illustrating the K m and V max for CYP 1 B 1 O-deethylation of ethoxyresorufin.

Ингибитор TMS Synonym: 2, 3', 4, 5'-Tetramethoxystilbene; 1 -[(1 E)2 -(3, 5 -dimethoxyphenyl)ethenyl]-2, 4 dimethoxy-benzene Application: An inhibitor of cytochrome P 450 1 B 1 and cancer cell growth Molecular Weight: 300. 35 Molecular Formula: C 18 H 20 O 4

Ингибитор Alizarin (CAS 72 -48 -0) Application: A biological stain with dye content 97% and color index number: 58000 CAS Number: 72 -48 -0 Molecular Weight: 240. 21 Molecular Formula: C 14 H 8 O 4 Refer to Certificate of Analysis for lot specific data (including water content).

Список источников 1. 2. 3. 4. 5. 6. 7. 8. Poulos T. L. Heme Enzyme Structure and Function / Chemical Reviews 2014 114 (7), 3919 -3962 Shimada T. , Watanabe J. , Kawajiri K. Catalytic properties of polymorphic human cytochrome P 450 1 B 1 variants // Carcinogenesis. 1999. Vol. 20, № 8. P. 1607– 1613. Choudhary D. , Jansson I. , Stoilov I. Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P 450 1 b 1 // Drug Metabolism and Disposition 2004. Vol. 32, № 8. P. 840– 847. Badal S. , Delgoda R. CYP 1 B 1: friend or foe? A critical review // Biochemistry. 2013. Vol. 1, № 1. P. 1– 7. Uni. Prot database: http: //www. uniprot. org/uniprot/Q 16678 Protein database: http: //www. rcsb. org/ Lewis D. F. V et al. Homology modelling of human CYP 1 A 2 based on the CYP 2 C 5 crystallographic template structure. // Xenobiotica. 2003. Vol. 33, № 3. P. 239– 254. http: //www. scbt. com/chemicals-table-cyp 1 b 1_inhibitors. html