Cumulative Genetic Risk and APOE 4 Are Independently

Cumulative Genetic Risk and APOE ε 4 Are Independently Associated With Dementia Status in

Table 1 Bivariate Analyses of Covariates by Cognition Status Stratified by Ancestry Among Health

Table 2 Odds Ratios (ORs) of Cognitive Status, Relative to Normal Status, Explained by

Figure 1 Classification of Dementia vs Normal Cognition Status Using Demographics, APOE, and Polygenic

Kelly M. Bakulski et al. Neurol Genet 2021; 7: e 576 Copyright © 2021

Slides: 5

Cumulative Genetic Risk and APOE ε 4 Are Independently Associated With Dementia Status in a Multiethnic, Population-Based Cohort by Kelly M. Bakulski, Harita S. Vadari, Jessica D. Faul, Steven G. Heeringa, Sharon L. R. Kardia, Kenneth M. Langa, Jennifer A. Smith, Jennifer J. Manly, Colter M. Mitchell, Kelly S. Benke, and Erin B. Ware Neurol Genet Volume 7(2): e 576 March 5, 2021 Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Table 1 Bivariate Analyses of Covariates by Cognition Status Stratified by Ancestry Among Health and Retirement Study (HRS) Participants With Core Measurements Taken From 1995 to 2014. Kelly M. Bakulski et al. Neurol Genet 2021; 7: e 576 Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Table 2 Odds Ratios (ORs) of Cognitive Status, Relative to Normal Status, Explained by 1 SD Increase of Polygenic Score and the Presence of an APOE ε 4 Allele in Participants in the Health and Retirement Study (HRS), of European and African Ancestries, Adjusted for Age, Sex, Education, Year of Last Visit, Genetic Principal Component (PC) 1, and Genetic PC 2. Kelly M. Bakulski et al. Neurol Genet 2021; 7: e 576 Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Figure 1 Classification of Dementia vs Normal Cognition Status Using Demographics, APOE, and Polygenic Score Kelly M. Bakulski et al. Neurol Genet 2021; 7: e 576 Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.