CRPV cottontail rabbit papillomaviruses 10067305 Virus function n
CRPV (cotton-tail rabbit papillomaviruses) 報告者:洪晟綱 10067305 老師:石麗仙老師
Virus function n CRPV induces cutaneous papillomas (warts) in cottontail rabbits and may cause keratinous carcinomas, typically on or near the animal’s head n These tumors can become large enough that they interfere with the host’s ability to eat, eventually causing starvation n CRPV-associated carcinomas contain the viral DNA that is transcriptionally active, and the carcinogenic properties are believe to map to specific viral genes.
Finder n Richard E Shope identified CRPV as the etiologic agent of cutaneous papillomatosis in rabbits. (1930) n Shope was able to isolate virus particles from tumors on captured animals and use these to inoculate domestic rabbits, which then developed similar tumors n Thus the virus is also called “Shope papilloma virus”
Virus + external factors In the case of CRPV, carcinomas develop at an increased frequence in papillomas that are painted with cool tar or with MCA
importance n �he cottontail rabbit papillomavirus T (CRPV)/rabbit model has proven to be the most versatile pre-clinical model to test antiviral, immunopotentiating and immunotherapeutic strategies for papilloma-virus infections. n Many of the treatments already tested in the CRPV/rabbit model have shown parallel efficacy against HPV infections in a clinical setting.
bonus The CRPV is also a possible source of myths about the jackalope n The jackalope is a mythical animal of North American folklore n
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