CPIC Informatics Working Group CPIC Informatics Working Group

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CPIC Informatics Working Group

CPIC Informatics Working Group

CPIC Informatics Working Group • Growing interest in informatics aspects of CPIC guidelines and

CPIC Informatics Working Group • Growing interest in informatics aspects of CPIC guidelines and clinical implementation of pharmacogenetics • Working group will create a forum for discussion and collaboration focused on informatics issues • Goal – To support the adoption of the CPIC guidelines by identifying, and resolving where possible, potential technical barriers to the implementation of the guidelines within a clinical electronic environment.

Organization • Subgroup within CPIC – Close coordination with CPIC leadership – Regular updates

Organization • Subgroup within CPIC – Close coordination with CPIC leadership – Regular updates on monthly call – Members of working group must be CPIC members and follow MOU • Working group leaders – Bob Freimuth (Mayo Clinic) – James Hoffman (St. Jude) – Michelle Carrillo (Pharm. GKB)

CPIC Informatics Working Group: Initial Goal • Create comprehensive translation tables from genotype to

CPIC Informatics Working Group: Initial Goal • Create comprehensive translation tables from genotype to phenotype to clinical recommendation for CPIC guidelines – Define structure and process to efficiently develop and maintain in the most useful format(s) – Will be published as part of CPIC guidelines and posted on Pharm. GKB – Will collaborate with and support PGRN TPP

CPIC Informatics: Supporting Guideline Implementation Guideline Development and Publication Guideline Adoption and Implementation CPIC

CPIC Informatics: Supporting Guideline Implementation Guideline Development and Publication Guideline Adoption and Implementation CPIC TPP Coordinate Refinements Feedback from Local Implementations CPIC Informatics Genotype Phenotype Recommendation Creation and Maintenance of Translation Tables • Human-readable • Structured text • Formal knowledge representation

CPIC Informatics Working Group: Other Opportunities • Facilitate the incorporation of CPIC guidelines in

CPIC Informatics Working Group: Other Opportunities • Facilitate the incorporation of CPIC guidelines in clinical electronic references (e. g. , Epocrates) • Develop recommendations for Clinical Decision Support (CDS) rules based on the CPIC guidelines • Work with EMR vendors to incorporate CPIC guidelines and related information into EMRs • Work with standards development organizations to create content to support the CPIC guidelines (e. g. , terms to define metabolizer status) • Generate computable representations of the CPIC guidelines using formal knowledge representation and standard terminologies

Participation in CPIC Informatics • Open to all CPIC members • Get on the

Participation in CPIC Informatics • Open to all CPIC members • Get on the email list – Send an email to Bob, James, and Michelle • Conference call schedule TBD