Coronary Phantom Design for Kedge Angiography John Jorgensen

MXI Systems l MX 200 – Applications • • • Radiotherapy Crystallography Mammography Pediatrics

Project Background l Monochromatic tunable X-ray: – Reduced radiation dose to patient – Reduced

Project Goals l Design a coronary phantom l Test contrast agent concentrations – hypersensitivity

Solution Description Radio Translucent at 35 ke. V l Flexible material l – Fluid

Phantom Designs Solid. Works Model Preliminary Sketch Shelley Medical Imaging Technologies www. simutech. com

Material - Reo. Flex ™ Rubber l Physical Properties – Flexible cured product –

Schedule Research Material Testing & Design Manufacturing Testing November December January February March April

Current Status l Work Completed – Material Selected – Solid. Works Design Completed –

Future Plans l March – Send for Prototype – Start Testing • Test Dosimetry

Team and Resources Advisor: Dr. Frank Carroll, M. D. l Monochromatic x-ray machine l

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Coronary Phantom Design for K-edge Angiography John Jorgensen Sarah Pachtman Punam Patel Marcus Spallek Advisor: Dr. Frank Carroll

MXI Systems l MX 200 – Applications • • • Radiotherapy Crystallography Mammography Pediatrics K-edge Imaging – Angiography? ? ? http: //www. onlinetelemedicine. com/html/product/sa m_images/Angiography. jpg

Project Background l Monochromatic tunable X-ray: – Reduced radiation dose to patient – Reduced contrast agent concentrations • K-edge imaging Diagram of MX 200’s laser paths and major elements FOR MORE INFO. . . http: //www. mxisystems. com/mx 200. html Free Electron Laser Laboratory http: //www. vanderbilt. edu/fel/ .

K-edge Effect

Project Goals l Design a coronary phantom l Test contrast agent concentrations – hypersensitivity reaction to iodine (3 -12% patients) – current clinical dilution is 1: 16 – using monochromatic plain films it is possible to see 1: 256 dilutions l Determine optimal angle for stereo imaging Tan θ = 3/30 = 0. 10 3” 30” θ θ ~ 6°

Solution Description Radio Translucent at 35 ke. V l Flexible material l – Fluid perfusion l Phantom Size – 7. 5 cm diameter l Vasculature – Size Range 5 - 0. 5 mm – Coronary arteries on surface – Curved channels – Hollow vessels Finger imaged at 19 ke. V 26 ke. V

Phantom Designs Solid. Works Model Preliminary Sketch Shelley Medical Imaging Technologies www. simutech. com

Material - Reo. Flex ™ Rubber l Physical Properties – Flexible cured product – 2 -component liquid resin system – Room-temperature cure – 20 Shore A durometer – 60 pli tear strength – 200 psi tensile strength – Elongation at Break 1000% www. smooth-on. com

Schedule Research Material Testing & Design Manufacturing Testing November December January February March April FOR MORE INFO. . . http: //vubme. vuse. vanderbilt. edu/srdesign/2003/group 12/NCIIA %20 Grant%20 Proposal. htm

Current Status l Work Completed – Material Selected – Solid. Works Design Completed – ZCORP Contacted (Manufacturer) • Rapid Prototyping Machine

Future Plans l March – Send for Prototype – Start Testing • Test Dosimetry for Imaging • Test for Optimal Stereo Angle – Start Final Report

Team and Resources Advisor: Dr. Frank Carroll, M. D. l Monochromatic x-ray machine l W. M. Keck Free-electron Laser (FEL) Center at Vanderbilt University l Materials and tools provided by BME Department and FEL Center l – Polyurethane resins from outside contractors Photograph of device with laser cover removed http: //www. vanderbilt. edu/fel/Xray/manuscripts/final%20 report%20 for%20 ONR%20 grant%2020021218. doc

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