Core Facilities at UCSF and Beyond Teri Liegler

Core Facilities at UCSF and Beyond Teri Liegler, Ph. D Director ARI-UCSF Laboratory of Clinical Virology CFAR Virology Core Laboratory tliegler@sfgh. ucsf. edu 11/20/2015 CFAR Mentoring

What is a core facility? • NIH Definition – “A centralized, shared resource that provides scientific investigators with access to instruments; technologies; services; cellular, animal or human study support; and expert consultation” • >80 at UCSF and affiliated institutions 11/20/2015 CFAR Mentoring

Core Facility Mission at UCSF • Service: Provides cutting-edge and state-of-the-art technologies and expertise in an efficient operation • Education: Provides explicit training in the proper application of technology and analysis of the data produced • R & D: Provides an environment for technology and application development, broadening the use and applicability of research tools globally and enhancing local discovery 11/20/2015 CFAR Mentoring

Why and when to use a core? • • Expand your research scope and capacity Expedite progress by using services already up and running Save money by ‘renting’ rather than ‘buying’ Gain critical insight by consulting with experts throughout the study – Especially at the inception stage 11/20/2015 CFAR Mentoring

What are the CFAR cores? • Clinical/Population Science – Jeff Martin MD, MPH, Steve Deeks MD • Immunology – Jeff Milush Ph. D • Pharmacology – Fran Aweeka Pharm. D • Specimen Banking – John Greenspan BDS, Ph. D, Yvonne De. Souza • Virology – Teri Liegler, Ph. D 11/20/2015 CFAR Mentoring

Why are CFAR cores special? • Cores are a business, but not really… – Mandate to support & enhance institutional research – Restricted on how we can make and spend money – Must be cost neutral, can’t show profit • CFAR funds 5 cores to promote ‘Value Added’ services – Education, training and mentoring – State of the art equipment – New assay development – “Conception − to − Publication” support for projects 11/20/2015 CFAR Mentoring

Managing core use can be daunting! Specimens Nucleic Acid Extraction and Modification Bioinformatics HIV Sequencing 11/20/2015 CFAR Mentoring Genomic SNP Analysis

Core Synergy at Work! CFAR Clin and Specimen Core = CFAR Immunology Core Manuscript CFAR Virology Core 11/20/2015 CFAR Mentoring UCSF Genomics Core

How do I find the right Core? 11/20/2015 CFAR Mentoring

121410 CFAR Mentoring

Gladstone Cores 11/20/2015 CFAR Mentoring

But can I afford using a core? • You get what you pay for! – Quality, accountability and experience • Sometimes, time is $$ • May partially cover costs for new development work • Consult with core director on study design, hypothesis, sample selection and services early in process • Institutional supplements 11/20/2015 CFAR Mentoring

Funding Opportunities for Core Use • UCSF Resource Allocation Program (RAP) – Career Development – International – Multidisciplinary – Pilots – Technology • For CFAR sponsored, encourage use of CFAR Cores • Gilead Sciences Research Scholars Program in HIV • amf. AR Institute for HIV Cure Research 11/20/2015 CFAR Mentoring

• • • Pilot program up to $4, 000 Remove barriers for 1 st time core users Expand the scope and breadth of core users Spark new offerings and collaborations with cores Easy app, rapid turnaround, 6 month duration

Thank You! Questions? tliegler@sfgh. ucsf. edu 206 -8929 11/20/2015 CFAR Mentoring