Cooperative leukemogenesis in acute myeloid leukemia and acute

MYC and TRIB 1 co-operate to initiate acute myeloid leukemia (AML), whereas MYC alone

Summary table of the outcome of the in vivo leukemogenesis experiment, specifying the phenotype

TRIB 1 expression is decreased in human acute promyelocytic leukemia (APL) and does not

TRIB 1 overexpression blocks the ATRA-mediated differentiation of NB 4 cells. Karen Keeshan et

TRIB 1 overexpression abrogates ATRA response in vivo. Karen Keeshan et al. Haematologica 2016;

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Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBPα as a common target of TRIB 1 and PML/RARA by Karen Keeshan, Pauline Vieugué, Shahzya Chaudhury, Loveena Rishi, Coline Gaillard, Lu Liang, Elaine Garcia, Takuro Nakamura, Nader Omidvar, and Scott C. Kogan haematol Volume 101(10): 1228 -1236 September 30, 2016 © 2016 by Ferrata Storti Foundation

MYC and TRIB 1 co-operate to initiate acute myeloid leukemia (AML), whereas MYC alone combined with PML/RARA is able to drive acute promyelocytic leukemia (APL). Karen Keeshan et al. Haematologica 2016; 101: 1228 -1236 © 2016 by Ferrata Storti Foundation

Summary table of the outcome of the in vivo leukemogenesis experiment, specifying the phenotype of the leukemia or cause of death in the first column, disease latency (time to death column), mean time to disease, and input (donor) bone marrow (BM) specified. . . Karen Keeshan et al. Haematologica 2016; 101: 1228 -1236 © 2016 by Ferrata Storti Foundation

TRIB 1 expression is decreased in human acute promyelocytic leukemia (APL) and does not correlate with MYC expression. Karen Keeshan et al. Haematologica 2016; 101: 1228 -1236 © 2016 by Ferrata Storti Foundation