Control of Gene Expression Chapter 7 Lecture 03
- Slides: 16
Control of Gene Expression Chapter # 7 Lecture # 03 06 -01 -2020
Experiment demonstrating the modular construction of the Eve gene regulatory region.
The Drosophila Eve Gene Is Regulated by Combinatorial Controls The Eve stripe 2 unit.
Distribution of the transcription regulators responsible for ensuring that Eve is expressed in stripe 2.
The integration of multiple inputs at a promoter
Transcription Regulators Are Brought Into Play by Extracellular Signals
Combinatorial Gene Control Creates Many Different Cell Types The importance of combinatorial gene control for development.
A small set of transcription regulators can convert one differentiated cell type into another
Expression of the Drosophila Eyeless gene in precursor cells of the leg triggers the development of an eye on the leg.
Specialized Cell Types Can Be Experimentally Reprogrammed to Become Pluripotent Stem Cells A combination of transcription regulators can induce a differentiated cell to dedifferentiate into a pluripotent cell.
A portion of the transcription network specifying embryonic stem cells
Differentiated Cells Maintain Their Identity A single transcription regulator can coordinate the expression of many different genes.
A positive feedback loop can create cell memory.
Transcription Circuits Allow the Cell to Carry Out Logic Operations
How a feed-forward loop can measure the duration of a signal
The exceedingly complex gene circuit that specifies a portion of the developing sea urchin embryo