Contagious bovine pleuropneumonia Contagious Bovine Pleuropneumonia Overview Organism
![Contagious bovine pleuropneumonia Contagious Bovine Pleuropneumonia Contagious bovine pleuropneumonia Contagious Bovine Pleuropneumonia](https://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-1.jpg)
Contagious bovine pleuropneumonia Contagious Bovine Pleuropneumonia
![Overview Organism Economic Impact Epidemiology Transmission Clinical Signs Diagnosis and Treatment Prevention and Control Overview Organism Economic Impact Epidemiology Transmission Clinical Signs Diagnosis and Treatment Prevention and Control](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-2.jpg)
Overview Organism Economic Impact Epidemiology Transmission Clinical Signs Diagnosis and Treatment Prevention and Control Actions to Take
![The Organism The Organism](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-3.jpg)
The Organism
![Contagious Bovine Pleuropneumonia (CBPP) Mycoplasma mycoides subsp. mycoides Small colony type Quickly inactivated in Contagious Bovine Pleuropneumonia (CBPP) Mycoplasma mycoides subsp. mycoides Small colony type Quickly inactivated in](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-4.jpg)
Contagious Bovine Pleuropneumonia (CBPP) Mycoplasma mycoides subsp. mycoides Small colony type Quickly inactivated in environment Does not survive in meat or meat products African and European lineages
![Importance Importance](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-5.jpg)
Importance
![History 1693: First reported case of CBPP Germany; spread all over Europe Enters U. History 1693: First reported case of CBPP Germany; spread all over Europe Enters U.](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-6.jpg)
History 1693: First reported case of CBPP Germany; spread all over Europe Enters U. S. - dairy cow from England 1884: CBPP widespread in U. S. Federal government establishes Bureau of Animal Industry to combat CBPP 1887: Quarantine, slaughter begin 1893: CBPP eradicated from U. S.
![Economic Impact Countries with high incidence of CBPP Zambia, Tanzania, Botswana High economic, social Economic Impact Countries with high incidence of CBPP Zambia, Tanzania, Botswana High economic, social](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-7.jpg)
Economic Impact Countries with high incidence of CBPP Zambia, Tanzania, Botswana High economic, social impact Rapid spread of disease Vaccination programs reduced Drought conditions lead to increased animal movement Threatened social well-being, survival
![Epidemiology Epidemiology](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-8.jpg)
Epidemiology
![Geographic Distribution Reported cases to the OIE , January – June 2013 Geographic Distribution Reported cases to the OIE , January – June 2013](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-9.jpg)
Geographic Distribution Reported cases to the OIE , January – June 2013
![Morbidity/Mortality Morbidity Increases with close confinement Can reach 100% in susceptible herds Mortality Ranges Morbidity/Mortality Morbidity Increases with close confinement Can reach 100% in susceptible herds Mortality Ranges](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-10.jpg)
Morbidity/Mortality Morbidity Increases with close confinement Can reach 100% in susceptible herds Mortality Ranges from 30 to 80% Affected by secondary factors 25% of recovered animals may become CBPP carriers
![Transmission Transmission](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-11.jpg)
Transmission
![Animal Transmission Introduction of carrier animal Most common cause of outbreaks Aerosol (close contact) Animal Transmission Introduction of carrier animal Most common cause of outbreaks Aerosol (close contact)](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-12.jpg)
Animal Transmission Introduction of carrier animal Most common cause of outbreaks Aerosol (close contact) Direct contact Saliva, urine, fetal membranes, Transplacental Humans are not susceptible uterine discharges
![Animals and CBPP Animals and CBPP](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-13.jpg)
Animals and CBPP
![Species Affected Cattle Asian buffalo Captive bison Yak Humans are not susceptible Species Affected Cattle Asian buffalo Captive bison Yak Humans are not susceptible](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-14.jpg)
Species Affected Cattle Asian buffalo Captive bison Yak Humans are not susceptible
![Clinical Signs: Acute Infection Incubation period: 21 to 180 days Initial signs Lethargy, anorexia, Clinical Signs: Acute Infection Incubation period: 21 to 180 days Initial signs Lethargy, anorexia,](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-15.jpg)
Clinical Signs: Acute Infection Incubation period: 21 to 180 days Initial signs Lethargy, anorexia, fever, cough Extended head/neck Later signs Thoracic pain, reluctance to move Elbow abduction, moaning during expiration Increased respiratory rate
![Clinical Signs: Acute Infection Extended head/neck Coughing Unusual posture Neck forward Legs far apart Clinical Signs: Acute Infection Extended head/neck Coughing Unusual posture Neck forward Legs far apart](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-16.jpg)
Clinical Signs: Acute Infection Extended head/neck Coughing Unusual posture Neck forward Legs far apart Elbows turned out
![Clinical Signs: Chronic Infection Less obvious signs of pneumonia Coughing with exercise Emaciation Recurrent Clinical Signs: Chronic Infection Less obvious signs of pneumonia Coughing with exercise Emaciation Recurrent](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-17.jpg)
Clinical Signs: Chronic Infection Less obvious signs of pneumonia Coughing with exercise Emaciation Recurrent mild fever Appear to recover after several weeks Calves Polyarthritis +/- pneumonia Subclinical cases can be carriers
![Clinical Signs: Chronic Infection Emaciation, depression Clinical Signs: Chronic Infection Emaciation, depression](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-18.jpg)
Clinical Signs: Chronic Infection Emaciation, depression
![Post Mortem Lesions Lung Thickening Extensive fibrin and fibrosis Marbling Thoracic cavity Encapsulated Straw-colored Post Mortem Lesions Lung Thickening Extensive fibrin and fibrosis Marbling Thoracic cavity Encapsulated Straw-colored](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-19.jpg)
Post Mortem Lesions Lung Thickening Extensive fibrin and fibrosis Marbling Thoracic cavity Encapsulated Straw-colored fluid May be necrotic Joints enlarged
![Post Mortem Lesions: Thoracic Cavity Fibrin Fluid in thoracic cavity Post Mortem Lesions: Thoracic Cavity Fibrin Fluid in thoracic cavity](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-20.jpg)
Post Mortem Lesions: Thoracic Cavity Fibrin Fluid in thoracic cavity
![Post Mortem Lesions: Joints Proliferation of connective tissue Tendosynovitis and arthritis Fibrin in synovial Post Mortem Lesions: Joints Proliferation of connective tissue Tendosynovitis and arthritis Fibrin in synovial](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-21.jpg)
Post Mortem Lesions: Joints Proliferation of connective tissue Tendosynovitis and arthritis Fibrin in synovial space Articular cartilage erosion
![Sampling Before collecting or sending any samples, the proper authorities should be contacted Samples Sampling Before collecting or sending any samples, the proper authorities should be contacted Samples](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-22.jpg)
Sampling Before collecting or sending any samples, the proper authorities should be contacted Samples should only be sent under secure conditions and to authorized laboratories to prevent the spread of the disease
![Diagnosis: Clinical Difficult to distinguish from other respiratory diseases in cattle Clinical indicators Unilateral Diagnosis: Clinical Difficult to distinguish from other respiratory diseases in cattle Clinical indicators Unilateral](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-23.jpg)
Diagnosis: Clinical Difficult to distinguish from other respiratory diseases in cattle Clinical indicators Unilateral pneumonia Polyarthritis in calves Post mortem lesions
![Differential Diagnosis Bovine pasteurellosis (mannheimiosis) Hemorrhagic septicemia Theileriosis (East Coast fever) Bovine ephemeral fever Differential Diagnosis Bovine pasteurellosis (mannheimiosis) Hemorrhagic septicemia Theileriosis (East Coast fever) Bovine ephemeral fever](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-24.jpg)
Differential Diagnosis Bovine pasteurellosis (mannheimiosis) Hemorrhagic septicemia Theileriosis (East Coast fever) Bovine ephemeral fever Rinderpest Traumatic pericarditis
![Diagnosis: Laboratory Culture Immunological tests PCR Serology Complement fixation Competitive ELISA Immunoblot Latex agglutination Diagnosis: Laboratory Culture Immunological tests PCR Serology Complement fixation Competitive ELISA Immunoblot Latex agglutination](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-25.jpg)
Diagnosis: Laboratory Culture Immunological tests PCR Serology Complement fixation Competitive ELISA Immunoblot Latex agglutination
![Treatment Recommended only in endemic areas Elimination of organism may be impossible Carriers may Treatment Recommended only in endemic areas Elimination of organism may be impossible Carriers may](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-26.jpg)
Treatment Recommended only in endemic areas Elimination of organism may be impossible Carriers may develop Antibiotics generally ineffective Recommended action in outbreak Slaughter and necropsy suspect animals
![CBPP in Humans are not susceptible. CBPP in Humans are not susceptible.](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-27.jpg)
CBPP in Humans are not susceptible.
![Prevention and Control Prevention and Control](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-28.jpg)
Prevention and Control
![Quarantine and Disinfection Quarantine Test and slaughter Exposed animals Infected animals Disinfection 3% Sodium Quarantine and Disinfection Quarantine Test and slaughter Exposed animals Infected animals Disinfection 3% Sodium](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-29.jpg)
Quarantine and Disinfection Quarantine Test and slaughter Exposed animals Infected animals Disinfection 3% Sodium hypochlorite
![Vaccination Vaccine efficacy varies T 1/44 strain Eradication Limit of disease spread May not Vaccination Vaccine efficacy varies T 1/44 strain Eradication Limit of disease spread May not](http://slidetodoc.com/presentation_image/22e1da49267cd864cca88e73971ee0f8/image-30.jpg)
Vaccination Vaccine efficacy varies T 1/44 strain Eradication Limit of disease spread May not be possible due to economic constraints
- Slides: 30