Comparison of MAPIE versus MAP in patients with

Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an openlabel, international, randomised controlled trial Prof Neyssa M Marina, MD, Prof Sigbjørn Smeland, MD, Prof Stefan S Bielack, MD, Prof Mark Bernstein, MD, Gordana Jovic, Ph. D, Mark D Krailo, Ph. D, Jane M Hook, MRCP, Prof Carola Arndt, MD, Henk van den Berg, MD, Bernadette Brennan, MD, Prof Bénédicte Brichard, MD, Ken L B Brown, MD, Trude Butterfass-Bahloul, MD, Gabriele Calaminus, MD, Heike E Daldrup-Link, MD, Mikael Eriksson, MD, Mark C Gebhardt, MD, Prof Hans Gelderblom, MD, Joachim Gerss, Ph. D, Robert Goldsby, MD, Allen Goorin, MD, Prof Richard Gorlick, MD, Prof Holcombe E Grier, MD, Juliet P Hale, MD, Kirsten Sundby Hall, MD, Prof Jendrik Hardes, MD, Douglas S Hawkins, MD, Prof Knut Helmke, MD, Prof Pancras C W Hogendoorn, MD, Michael S Isakoff, MD, Katherine A Janeway, MD, Prof Heribert Jürgens, MD, Leo Kager, MD, Prof Thomas Kühne, MD, Ching C Lau, MD, Prof Patrick J Leavey, MD, Prof Stephen L Lessnick, MD, Leo Mascarenhas, MD, Prof Paul A Meyers, MD, Hubert Mottl, MD, Prof Michaela Nathrath, MD, Prof Zsuzsanna Papai, MD, Prof R Lor Randall, MD, Peter Reichardt, MD, Marleen Renard, MD, Akmal Ahmed Safwat, Ph. D, Prof Cindy L Schwartz, MD, Prof Michael C G Stevens, MD, Sandra J Strauss, Ph. D, Lisa Teot, MD, Mathias Werner, MD, Matthew R Sydes, MSc, Prof Jeremy S Whelan, MD The Lancet Oncology Volume 17 Issue 10 Pages 1396 -1408 (October 2016) DOI: 10. 1016/S 1470 -2045(16)30214 -5 Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 1 The Lancet Oncology 2016 171396 -1408 DOI: (10. 1016/S 1470 -2045(16)30214 -5) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 2 The Lancet Oncology 2016 171396 -1408 DOI: (10. 1016/S 1470 -2045(16)30214 -5) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 3 The Lancet Oncology 2016 171396 -1408 DOI: (10. 1016/S 1470 -2045(16)30214 -5) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions