Common Names of Simple Aldehydes and Ketones Common

Common Names of Simple Aldehydes and Ketones

Common Names of Carbonyl substituents

Preparation of Aldehydes and Ketones : Review 1. Oxidation of 1 alcohols to aldehydes: a. PCC b. Dess-Martin Periodinane

Preparation of Aldehydes and Ketones : Review 1. Oxidation of 1 alcohols to aldehydes: a. PCC b. Dess-Martin Periodinane

Preparation of Aldehydes and Ketones : Review 2. Oxidation of 2 alcohols to ketones: a. Cr. O 3 , H 2 SO 4 b. K 2 Cr 2 O 7, H 2 SO 4 c. PCC d. Dess - Martin

Preparation of Aldehydes and Ketones : Review 2. Oxidation of 2 alcohols to ketones: a. Cr. O 3 , H 2 SO 4 b. K 2 Cr 2 O 7, H 2 SO 4 c. PCC d. Dess - Martin

Preparation of Aldehydes and Ketones : Review 3. Aryl aldehydes and ketones: Friedel – Crafts Acylation

Preparation of Aldehydes and Ketones : Review 3. Aryl aldehydes and ketones: Friedel – Crafts Acylation

Preparation of Aldehydes and Ketones:

Preparation of Aldehydes and Ketones: 1. Ketones From Acid Chlorides via Acyl Transfer Using R 2 Cu. Li (Section 16. 4)

Preparation of Aldehydes and Ketones: 1. Ketones From Acid Chlorides via Acyl Transfer Using R 2 Cu. Li (Section 16. 4) 2. Aldehydes From Esters Reduction with DIBAH (Section 16. 6)

Oxidation of Aldehydes : Review a. Cr. O 3, H 2 SO 4 b. K 2 Cr 2 O 7, H 2 SO 4

Oxidation of Aldehydes : Review a. Cr. O 3, H 2 SO 4 b. K 2 Cr 2 O 7, H 2 SO 4

Nucleophilic Additions to Aldehydes and Ketones I. Reactivity 1. Aldehydes vs. ketones

Nucleophilic Additions to Aldehydes and Ketones I. Reactivity 1. Aldehydes vs. ketones 2. Aromatic vs. aliphatic

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic 2. Neutral

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic 2. Neutral i. Water a. hydrates Acid catalyzed Base catalyzed

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic 2. Neutral i. Water ii. Alcohols a. acetals

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic 2. Neutral i. Water ii. Alcohols iii. 1 amines and hydrazines

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic 2. Neutral i. Water ii. Alcohols iii. 1 amines and hydrazines a. imines

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic 2. Neutral i. Water ii. Alcohols iii. 1 amines and hydrazines a. imines b. hydrazones c. Wolff-Kirshner Reduction

Nucleophilic Additions to Aldehydes and Ketones II. Types of Nucleophiles 1. Anionic 2. Neutral i. Water ii. Alcohols iii. 1 amines and hydrazines iv. 2 amines a. enamines

Professor Gilbert Stork was born in Brussels, Belgium, and received his secondary education in France. The B. S. (1942) and Ph. D. (1945) were obtained at the Universities of Florida and Wisconsin respectively. He was on the Harvard faculty (1946 -53), then joined the Columbia faculty where he was instrumental in building its strong organic group and is currently Eugene Higgins Professor Emeritus. Stork's many awards include the ACS Award in Pure Chemistry (1957), the ACS Award for Creative Work in Synthetic Organic Chemistry (1967), the Arthur C. Cope Award (1980), the Willard Gibbs Medal (1982), the National Medal of Science (1982), the Tetrahedron Prize (1985), the Roger Adams Award (1991) and the Wolf Prize (1996). In 2001 he published the first completely stereoselective total synthesis of quinine. http: //chem. tufts. edu/AMichael-Bio. html

Reactions of Ylides with Aldehydes I. The Wittig Reaction 1. The Metathesis reaction George Wittig 1979 Nobel Prize

Reactions of Ylides with Aldehydes I. The Wittig Reaction 1. The Metathesis reaction 2. Generation and nature of ylides George Wittig 1979 Nobel Prize

Reactions of Ylides with Aldehydes I. The Wittig Reaction 1. The Metathesis reaction 2. Generation and nature of ylides 3. Stereochemistry a. effect of the ylide George Wittig 1979 Nobel Prize

Reactions of Ylides with Aldehydes I. The Wittig Reaction 1. The Metathesis reaction 2. Generation and nature of ylides 3. Stereochemistry a. effect of the ylide 4. The Mechanism George Wittig 1979 Nobel Prize a. oxaphosphatane formation b. elimination

Reactivity of a, b-unsaturated carbonly compounds 1. Electrophilic sites

Reactivity of a, b-unsaturated carbonly compounds 1. Electrophilic sites

Reactivity of a, b-unsaturated carbonly compounds 1. Electrophilic sites 2. Hard-soft acid-base theory

Professor Author Michael Born in Buffalo NY in 1855, he studied chemistry at Heidelberg under Robert Bunsen (1811 -1899) and at Berlin under August Wilhelm Hofmann (1818 -1892). He then studied under Adolphe Wurtz (1817 -1884) in Paris and Dimitri Ivanoviè Mendeleev (1834 -1907) in St Petersburg, but never bothered to take a degree. He was made Professor of Chemistry at Tufts College near Boston. In 1889, he married one of his most brilliant students, (1857 -1904), one of the few women organic chemists Helen Cecilia De. Silver Abbott in this period. After a failed attempt to run the chemistry department at Clark University in Worcester, Massachusetts, in 1891, he spent three years working with his wife in his private laboratory on the Isle of Wight before returning to Tufts. After he retired from Tufts in 1907, Michael set up another private laboratory at Newton Center near Boston. In 1912 he was appointed a Professor of Chemistry, without lecturing duties, at Harvard University. Arthur Michael died in 1942. http: //chem. tufts. edu/AMichael-Bio. html

Reactivity of a, b-unsaturated carbonly compounds 1. Electrophilic sites 2. Hard-soft acid-base theory 3. Examples