COMMERCIAL TRANSLATION IN THE DEPARTMENT OF BIOMEDICAL INFORMATICS
COMMERCIAL TRANSLATION IN THE DEPARTMENT OF BIOMEDICAL INFORMATICS AND UNIVERSITY OF PITTSBURGH HEALTH SCIENCES DONALD P. TAYLOR, PHD, MBA, MS ASSISTANT VICE CHANCELLOR, COMMERCIAL TRANSLATION IN THE HEALTH SCIENCES ASSOCIATE PROFESSOR, DEPARTMENT OF BIOMEDICAL INFORMATICS EXECUTIVE DIRECTOR, SCIVELO 1
COMMERCIAL TRANSLATION FUNDING & COMMERCIALIZATION GOALS (FY 2018) GOAL 1 UPMC Funding to Pitt Health Sciences Commercial Translation GOAL 2 Outside Funding to Pitt Health Sciences Commercial Translation GOAL 3 Commercial Translation Outcomes • $2 M to Center for Commercial Application projects • $2 M to Immune Transplant & Therapy projects • $200 K to sci. Velo $4 M UPMC • $5 M from Major Industry Partners (e. g. Roche) • $500 K from Dental Craniofacial Resource Center • $500 K to sci. Velo $6 M Industry 60 Invention Disclosures 2 Licenses/Options 2 New Companies Formed School of Medicine Entrepreneurial Promotion & Tenure Policy Approved Translational Impact • • 2
COMMERCIAL TRANSLATION – BUILDING FROM FOUNDATIONAL SUCCESS STRATEGICALLY ADVANCE COMMERCIAL TRANSLATION THEMES BASED UPON DEMONSTRATED SUCCESS, STARTING WITH TRANSLATIONAL EXPERTISE IN DIGITAL HEALTH VIA THE CENTER FOR COMMERCIAL APPLICATIONS OF HEALTHCARE DATA HOUSED IN THE DEPARTMENT OF BIOMEDICAL INFORMATICS Planning Developing Growing Maturing 3
COMMERCIAL TRANSLATION ACTIVITY ACROSS SEVEN THEMES BUILDING EARLY WINS ACROSS ALL THEMES • • CENTER FOR COMMERCIAL APPLICATIONS DEPARTMENT OF BIOMEDICAL INFORMATICS INDUSTRY SPONSORED RESEARCH • • • EARLY-STAGE PORTFOLIO • DEVELOPMENT POST-ITTC FUNDING PROJECT DEVELOPMENT REVOLUTION FUND OMICS PHILANTHROPY • • • PHARMACOGENOMICS NIH U 24 DENTAL • CRANIOFACIAL RESOURCE CENTER MCCUNE FUNDED PEDIATRIC DEVICE INITIATIVE BIOBANK INDUSTRY SPONSORED RESEARCH • • CELL THERAPY SERVICE LINE (UPMC) 4
CENTER FOR COMMERCIAL APPLICATIONS OF HEALTHCARE DATA (CCA) • • • Center for Commercial Applications of Healthcare Data University of Pittsburgh PROJECT PIPELINES • 57 PROJECTS ACTIVELY MANAGED • PROJECTS SPAN 25 DEPARTMENTS AND 9 SCHOOLS ACROSSPITT • 27 PROJECTS PITCHED TO UPMC • 6 CCA FUNDED PROJECTS AT $3. 8 M COMMERCIALIZATION • 17 CCA INVENTION DISCLOSURES • 2 OPTIONS, 1 LICENSE, & 3 NEW COMPANY FORMATIONS COLLABORATORS 5
CENTER FOR COMMERCIAL APPLICATIONS OF HEALTHCARE DATA (CCA) TDI - TUMOR DRIVER IDENTIFICATION PIS: XINGHUA LU, MD, PHD | SCHOOL OF MEDICINE | DEPARTMENT OF BIOMEDICAL INFORMATICS GREG COOPER, MD, PHD | SCHOOL OF MEDICINE | DEPARTMENT OF BIOMEDICAL INFORMATICS KEY UPDATES Clinical Tools Personalized Cancer Medicine • $3. 8 M FOLLOW-ON The TDI System Cancer Sample Cancer genome data • ANTICIPATE FUNDING TO BE APPROVED – CONCERNS Genome Sequencing A 0 A 1 A 2 A 3 E 1 E 2 E 3 E 4 E 5 E 6 ~ $$ $$ FUNDING PROPOSAL SUBMITTED TO UPMC ENTERPRISES (JULY 2017) ~ Tumorspecific Driver Report Drug discovery & repurposing http: //tokuma. tumblr. com/post/11952871978 THAT FUNDING WILL GO THROUGH THE IMMUNE TRANSPLANT &THERAPY CENTER (ITTC) 6
CENTER FOR COMMERCIAL APPLICATIONS OF HEALTHCARE DATA (CCA) Spatial pathology powers cancer diagnostics Formerly Com. PACD PI: CHAKRA CHENNUBHOTLA, PHD |COMP. AND SYS. BIO. |MEDICINE CO-PIS: LANSING TAYLOR, PHD | DRUG DISCOVERY INSTITUTE | MEDICINE JEFFREY FINE, MD | DEPARTMENT OF PATHOLOGY | MEDICINE KEY UPDATES Histo. Guide™ Overview 1 Digital H&E Slides 3 Quantify Spatial Statistics 2 Stain Normalization • NEW COMPANY FORMED VIA PEPPER HAMILTON (JULY 2017) • CO-FOUNDING TEAM INCLUDES M. BECICH &D. L. TAYLOR, C. CHENNUBHOTLA, AND J. FINE • WRITING PHASE I/II SBIR GRANT FOR $1 M 4 Histo. Guide. TM Risk prioritized diagnostic scale 7
NEW MODEL FOR COMMERCIAL TRANSLATION • IDENTIFIES PORTFOLIO OF TRANSLATIONAL RESEARCH • PREPARES PROJECT TEAMS FOR FUNDING • GUIDES PROJECTS THROUGH • PROTECTS INTELLECTUAL PROPERTY • PROMOTES AND EXECUTES PITT LICENSING AGREEMENTS TRANSLATIONAL DEVELOPMENT • CONDUCTS FUNDING ASSESSMENTS • COMMERCIALIZES TECHNOLOGY • EXECUTES GRANTS AND GRANT APPLICATION SUBMISSIONS 8
SELECTED OUTCOMES (FISCAL 2017) INCREASE FUNDING FROM UPMC TO SUPPORT HEALTH SCIENCES TRANSLATIONAL RESEARCH THAT WILL ALSO PRECIPITATE TRANSLATIONAL PROJECTS ORIENTED TOWARD COMMERCIALIZATION INCREASE NUMBER AND QUALITY OF INVENTION DISCLOSURES TO INNOVATION INSTITUTE FOR INNOVATION INSTITUTE TO CONDUCT DOWNSTREAM LICENSING & NEW COMPANY FORMATION $200 K SPONSORED RESEARCH TO DBMI FOR PEDIATRIC CARDIAC TELEHEALTH MONITORING e. MOTO 24 INVENTION DISCLOSURES FILED INCREASE TRANSLATIONAL RESEARCH FUNDING VIA CORPORATE SPONSORS $125 K SPONSORED RESEARCH TO PITT’S DBMI INCREASE TRANSLATIONAL RESEARCH FUNDING VIA NIH $40 M OVER 5 YEARS $10. 8 M OVER 3 YEARS 9
RESEARCH &CLINICAL IMPACT – DONALD TAYLOR • Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, et al. A microphysiological system model of therapy for liver micrometastases. Experimental biology and medicine. 2014. PMCID: PMC 4574864 • Taylor DP, Clark A, Wheeler S, Wells A. Hepatic nonparenchymal cells drive metastatic breast cancer outgrowth and partial epithelial to mesenchymal transition. Breast Cancer Res Treat. 2014; 144(3): 55160. PMCID: PMC 4009995 • Yates CC, Nuschke A, Rodrigues M, Whaley D, Dechant JJ, Taylor DP, Wells A. Improved transplanted stem cell survival in a polymer gel supplemented with tenascin-C accelerates healing and reduces scarring of murine skin wounds. Cell Transplant. 2016 Jul 22. Michigan-Pittsburgh-Wyss Resource Center Supporting Regenerative Medicine in Dental, Oral and Craniofacial Technologies The goal of this RC is to translate TE/RM innovations that address the ongoing clinical need to restore or create healthy, functional DOC tissues. Grant number: 1 U 24 DE 0256915 -01 Granting agency: National Institutes of Health (NIH) Role on project: Co-Investigator %Effort: 5 Funding Period: 03/01/17 – 02/28/18 Funding Amount: $10, 800, 000 University of Pittsburgh Clinical and Translational Science Institute Grant number: 1 UL 1 TR 001857 -01 (PI: S. Reis) Granting agency: NIH/NCATS Role on project: Co-Investigator %Effort: 15 Funding Period: 07/12/2016 -05/31/2021 Funding Amount: $6, 300, 881
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