Clinical Results CA Surface Clinical research and product

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Clinical Results : CA Surface Clinical research and product management Team 18 th, May,

Clinical Results : CA Surface Clinical research and product management Team 18 th, May, 2016 www. befrest. com

1. CA Clinical Research Status Result of Clinical Research Progress (2 Cases) No. Research

1. CA Clinical Research Status Result of Clinical Research Progress (2 Cases) No. Research Theme Researcher Terms Research Progress Status 1 Clinical Prospective Research of TSIII CA Dental Implant on maxillary Molar(posterior) : Loading weight measurement from 6 week and 12 weeks Prof. YK, Kim (Seoul National University, Bundang Hospital) 2012 -2014 Poster Present 2 Early loading comparison between TSⅢ CA and ITI SLActive (Clinical Research of 8 weeks early loading comparison by Government funded Search Project) Prof. JH, Lee (Seoul National University) 2012 -2014 Poster Present www. befrest. com 2

1. CA Clinical Research Status ü Searcher : Prof. YK, Kim (Seoul National University

1. CA Clinical Research Status ü Searcher : Prof. YK, Kim (Seoul National University Bundang Hospital) ü Search Term : 2 Years (2012 ~ 2014) ü Search Materials and Method : 30 patients (Male : 13, Female : 17) - Group 1 : Healing Term 6 weeks, Group 2 : Healing Term 12 weeks - Osstell Measurement after prosthesis impression taking and prosthesis assembled (Verification of Dental Implant Stability) - Radiograph picture : Measurement on bone absorbed amount of alveolar crest ü Search Result : No TSIII CA Dental Implant Fall-Off among 30 patients Item ü (After Impression Taking) Osstell Value (Prosthesis assembled) Osstell Value Absorbed Bone Amount Group 1(6 w) 79. 38± 4. 73 72. 15± 26. 96 0. 14± 0. 25 mm Group 2(12 w) 77. 43± 4. 99 74. 43± 20. 88 0. 25± 0. 63 mm www. befrest. com Early Loading of Maxillary molar – Comparison Search between 6 weeks and 12 weeks (Alveolar Crest) Result : TSIII CA Dental Implant has good loading stability upon 6 weeks and 12 weeks 3

1. CA Clinical Research Status ü Searcher : Prof. JY, Lee (Prof. JH, Lee)

1. CA Clinical Research Status ü Searcher : Prof. JY, Lee (Prof. JH, Lee) – Seoul National University ü Search Term : 2 Years (2012 ~ 2014) ü Search Materials and Method : ISQ Value Measurement and Radiological assessment after dental implant installation with confirmed final follow-up 54 patients among early 65 patients. (Exposed group 27, Control Group 27) (Early Loading force failure 6, fail 2, F/up failure 3 patients) ü Research Result 1) ISQ Value : Gradual increasing on both group up-to 1 year after dental implant installation. - Experimental group : 75. 97(v 2), 78. 97(v 4), 85. 34(v 6, 1 yr) - Control group : 75. 44(v 2), 79. 11(v 4), 83. 43(v 6, 1 yr)   88. 00     84. 00 80. 00 76. 00 Experimental group Control group 72. 00 V 2 V 4 Visit V 6 Std. N Mean Deviation Min Max Experimental V 2 27 75. 97 1. 01 68 86 group V 4 27 78. 97 0. 95 66. 75 87   V 6 27 85. 34 0. 73 74 89. 5 Control group V 2 27 75. 44 1. 12 64 87 V 4 27 79. 11 0. 92 66 85. 5 V 6 27 83. 43 0. 61 76. 3 88. 5 68. 00   www. befrest. com Seoul National University – TSⅢ CA vs. Straumann SLActive 4

1. CA Clinical Research Status Seoul National University – TSⅢ CA vs. Straumann SLActive

1. CA Clinical Research Status Seoul National University – TSⅢ CA vs. Straumann SLActive - Radiographic measurements of distance between Implant shoulder and bone contact Visit 2 Visit 4 Visit 5 Visit 6 www. befrest. com 2) Marginal bone loss(1 yr) : CA 0. 05± 0. 03 mm, SLActive 0. 02± 0. 05 mm Measurement method 3) Soft tissue analysis : Decreasing calculus index & sulcus bleeding index dramatically of both group 6 month later 4) Failure Reason : Early Loading Force failure 6 patients (E=3, C-3), Osseointegration failure 2 month later (E=1), Osseointegration failure 6 month(C=1), F/up failure 3 patients(E=2, C=1) ü Result : Success Rate was 96% after 1 year f/up (Except f/up Failure 3 patients) 5

1. CA Clinical Research Status 1. Test Theme : Clinical Test of TSIII CA

1. CA Clinical Research Status 1. Test Theme : Clinical Test of TSIII CA Fixture – Launching Stage 2. Test Assessment : 154 dental Clinics 3. Test Purpose : Checking the market feedback by launching new product(New surface treatment stability verification), Securing verified clinical result by numerous dental clinics, utilizing the retrospective clinical search data. www. befrest. com Clinical test on launching stage 4. Test Date : July, 2012. 5. Test Method : Genera Observations and Case Summaries 6. Test Result : 1, 158 cases (139 dental clinics among 154 clinics) – 5 month later after launching the new product, Receiving VOC (8 cases) – 5 month later after launching the new product 1) Final Implant installation Torque : Almost of clinics follow the installation torque guide-line, which less then 40 Ncm by following the Guide 918 clinics (79%), 35~55 Ncm Over-Torque by 74 clinics(7%), Non-Checked info by 174 clinics. 2) Early Loading Force : More than <middle> 91%, <top> 42% 3) Receiving VOC : Fracture Mini mount (5 Cases), Fall-off (3 cases) - Result from 1, 158 patients, No Fall-Off case of TSIII CA) 7. Result : Averagely 5. 1 month later by 1, 158 Implant installation, 529 prosthesis completed, No failure, & No Adverse Reactions. 6

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations 1. Test Theme : Clinical

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations 1. Test Theme : Clinical Test of TSIII CA Fixture – 3 years later upon product launching 2. Test Assessment : Total 3 Dental Clinics 3. Assessment Purpose : Evaluate the stability of TS CA Fixture among natural teeth missing patients by final prosthesis completed status 4. Test Date : August, 2015 5. Test Method : Case Summaries and X-ray Pictures. 6. Test Result : 65 dental implanted installed for 47 patients of 3 dental clinics. 1) Distribution of implant installed area : Secure the enough initial fixation on soft bone case by installing the implants on maxillary molar 50. 77% 2) Initial Fixation : <Satisfied> 95. 4%, <excellent> 50. 78% 3) Satisfied index survey : 98. 5% satisfied 4) Failure and Complication possibilities : 0% - No Fall-Off of TSIII CA 7. Result : 31. 8 month later by 65 final prosthesis completed, No failure, & No Adverse Reactions www. befrest. com 7

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations <Case 1> • Name: Song

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations <Case 1> • Name: Song OO • Gender: Female(72 years old) • At 23 rd, July, 2012, on#23 install Ø 4. 5 x 11. 5 mm TS CA fixture, complete final prosthesis at 28 th, July, 2012. 3 years later upon final prosthesis completed date (5 th, July, 2015), there are no clinical complain, fractures, other complications, and clinical success with stable bone level. Surgery Final Prosthetics 1 yr Follow-up Final Follow-up 2012 -07 -23 2012 -08 -30 2013 -11 -04 2015 -07 -05 www. befrest. com ※ 3 Clinical Case 8

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations ※ 3 Clinical Case •

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations ※ 3 Clinical Case • Name: You OO • Gender: Male(51 years old) • At 16 th, October, 2012, on#37 install Ø 4. 5 x 8. 5 mm TS CA fixture complete final prosthesis at 21 st, Jan, 2013. 32 month later upon final prosthesis completed date (7 th, July, 2015), there are no clinical complain, fractures, other Surgery Final Prosthetics 1 yr Follow-up Final Follow-up 2012 -10 -16 2013 -01 -21 2014 -02 -11 2015 -07 -07 www. befrest. com <Case 2> 9

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations ※ 3 Clinical Case <Case

1. CA Clinical Research Status Licensing Purpose Clinical Evaluations ※ 3 Clinical Case <Case 3> • Gender: Female (59 years old) • At 1 st, Nov, 2012, on#37 install Ø 4. 5 x 10 mm TS CA fixture, complete final prosthesis at 3 rd, Jan, 2013. 32 month later upon final prosthesis completed date (20 th, July, 2015), there are no clinical complain, fractures, other complications, and clinical success with stable bone level. Surgery 2012 -11 -01 Final Prosthetics 1 yr Follow-up Final Follow-up 2013 -01 -03 2014 -02 -05 2015 -07 -20 www. befrest. com • Name: Choi OO 10

1. CA Clinical Research Status Clinical Test Progress Status 4 test case No. Test

1. CA Clinical Research Status Clinical Test Progress Status 4 test case No. Test Theme Researcher Test Term Status Prof. MR, Rae (Ihwa University) 2013 -2015 - 1 Clinical Survey of initial stability on Maxillary Molar Alveolar bone(Type III, IV), comparing Osstem TSIII CA vs Osstem TSIII SA dental implant. 2 Success & survival rate survey of TSIII CA Maxillary Molar (Sinus Lift) Prof. KM, Ahn(Seoul Ansan Hospital) 2013 -2015 On progressing 3 A bone gain technique in the maxillary sinus without bone grafts Prof. HJ, Yoon(Yei, Saint Mary Hospital) 2014 -2016 No Additional Issues. On F/Up stage 4 Simultaneous TSIII CA implant installation with sinus lift by alveolar crest approach Prof. YK, Kim (Bundang Seoul National University) 2014 -2016 On Surveying stage www. befrest. com 11

2. CA Clinical Articles No. Article Theme Announcer Date 1 CA TS implant :

2. CA Clinical Articles No. Article Theme Announcer Date 1 CA TS implant : Excellence in its early biologic response to bone and effectiveness in shortening of loading time in poor bone Ph. D IS, Jun Mar, 2013 2 Clinical Usefulness and characteristics of TSⅢ CA implant Ph. D YJ, Kim April, 2013 Remarks Denfo-Line 3, 4 Clinical Usefulness and characteristics of TSⅢ CA implant 1~2 5~7 Surface characteristic & Clinical Application of TSⅢ CA Ph. D YJ, Kim Dec, 2013 Ph. D CM, Yang Mar~May, 2014 8 Usefulness of TSIII CA on Bone Guided Regeneration(GBR) Ph. D YJ, Kim May, 2014 Dental News 9 Clinical application of TSIII CA 3. 0 on mandible anterior Ph. D JH, Jung Feb, 2016 Denfo-Line www. befrest. com 12

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 1) Loading case

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 1) Loading case after 8 weeks on poor bone quality & quantity case upon Socket preservation ISQ Monitoring(0 week : 72, 4 week : 78, 8 week : 82) www. befrest. com 13

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 2) Immediate installation

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 2) Immediate installation case by extraction on Buccal Corrugated Alveolar bone missing, loading by 2 weeks later ISQ Monitoring(0 week : 65, 1 week : 65, 2 week : 71) www. befrest. com 14

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 3) Maxillary Molar

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 3) Maxillary Molar current comparison TS(normal bone) vs. TS CA(extraction socket) à ISQ Monitoring TSⅢ(17) : 0 week 71/72, 8 week 75/76 vs. TSⅢ CA(16) : 0 week 65/63, 8 week 79/81 www. befrest. com 15

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 4) Immediate installation

2. CA Clinical Articles - Clinical Case Denfo-Line : 2013. 03 4) Immediate installation and loading after mandibles extraction Final Prosthesis completed upon 2 month later (ISQ value is more than 78) www. befrest. com 16

Thank you www. befrest. com

Thank you www. befrest. com