Clinical Research Network West of England Colorectal Cancer

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Clinical Research Network West of England Colorectal Cancer Research Report SWAG Site Specific Group

Clinical Research Network West of England Colorectal Cancer Research Report SWAG Site Specific Group Wednesday 29 th June 2016 Maxine Taylor Senior Research Delivery Manager - Cancer

South West Research Networks & SWAG West of England SWAG South West Peninsula

South West Research Networks & SWAG West of England SWAG South West Peninsula

Local Clinical Research Networks • Translation of national objectives for clinical research • Oversight

Local Clinical Research Networks • Translation of national objectives for clinical research • Oversight of research activity within the geography of CRN - West of England in terms of: • Portfolio • Balance, new studies, feasibility, industry trials • Performance • Support, network wide solutions, targets • People • Patient involvement, staff skill mix & flexibility, training, resources 3

National objectives • Timely set up of studies • Recruitment to time and target

National objectives • Timely set up of studies • Recruitment to time and target • Include commercial research

Objectives for cancer • Recruit 20% of cancer incidence • Recruit 7. 5% of

Objectives for cancer • Recruit 20% of cancer incidence • Recruit 7. 5% of cancer incidence into interventional studies • Include challenging studies • • Children and TYA cancers Rare cancers Surgical studies Radiotherapy studies

Recruitment to colorectal studies 2015 -16 am es Th t, Ke n Su rre

Recruitment to colorectal studies 2015 -16 am es Th t, Ke n Su rre nd ss e x st oa Su t. C es s la nd la su in id M W ya rth h ut So en s la nd id M ia br m Cu t. P es W st Ea rth rn te Ea s n do on nd la ng t. L es W No No nd ya h d an ut So st Ea lle Va rth No s nd la id r r be m Hu f. E to es W d an x te es ch an se es W on nd Lo am es Th es t. M W re hi rk s Yo r. M te ea Gr h ut So rth No Recruitment to colorectal studies 2015 -16 400 350 300 250 200 150 100 50 0

140 SWAG recruitment to colorectal cancer studies by Trust 2015 -16 120 1 3

140 SWAG recruitment to colorectal cancer studies by Trust 2015 -16 120 1 3 4 5 100 10 12 80 20 60 26 40 20 38 1 3 9 4 1 4 0 UHB HEAL CRC: DCT 2 2 2 Swindon Glos CORGI Pul. Mi. CC FOCUS-4 Aristotle 1 1 NBT 6 1 5 Bath Weston Does aspirin increase the clinical response to chemo-radiotherapy? 1 5 1 1 1 2 Taunton FOx. TROT Yeovil Inter. AACT NSCCG

SWAG recruitment to colorectal cancer studies by Trust 2016 -17 Q 1 7 6

SWAG recruitment to colorectal cancer studies by Trust 2016 -17 Q 1 7 6 5 4 3 2 1 0 UHB Bath FOx. TROT Glos Pul. Mi. CC CORGI NBT FOCUS-4 NSCCG HART Yeovil

Viewing the portfolio • http: //csg. ncri. org. uk/portfolio-maps/ Two studies in set up

Viewing the portfolio • http: //csg. ncri. org. uk/portfolio-maps/ Two studies in set up and will be open to new sites • Tracking mutations in cell free tumour DNA to predict Relapse in e. Arly Colorectal Cancer • Multicentre randomised feasibility trial evaluating Early Surgery Alone in Low rectal cancer (SAILOR)

Contacts • Research delivery manager – maxine. taylor@nihr. ac. uk • Colorectal specialty lead

Contacts • Research delivery manager – maxine. taylor@nihr. ac. uk • Colorectal specialty lead – Stephen. falk@uhbristol. nhs. uk