Cleavage and implantation Day 1 Day 14 http

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Cleavage and implantation Day 1 ===== Day 14 陳建榮 http: //web. nchu. edu. tw/pweb/users/chenjr/

Cleavage and implantation Day 1 ===== Day 14 陳建榮 http: //web. nchu. edu. tw/pweb/users/chenjr/

Cleavage in mammalian zygote

Cleavage in mammalian zygote

Morula 桑椹胚

Morula 桑椹胚

Mature Xenopus oocyte

Mature Xenopus oocyte

完全分裂(total or holoblastic cleavage): -Spiral cleavage -Radial cleavage

完全分裂(total or holoblastic cleavage): -Spiral cleavage -Radial cleavage

部份分裂(partial or meroblastic cleavage): -Incomplete cleavage -Superficial cleavage

部份分裂(partial or meroblastic cleavage): -Incomplete cleavage -Superficial cleavage

Cleavage in Zebra Fish

Cleavage in Zebra Fish

Monozygotic twin同卵雙生

Monozygotic twin同卵雙生

Morula stage 犬: 10 -11 days 家畜: 5 -9 days

Morula stage 犬: 10 -11 days 家畜: 5 -9 days

築巢性著床 (nidation) carnivores, ruminants, horses, and pigs 間質性著床 (interstitial) rats and mice humans, and

築巢性著床 (nidation) carnivores, ruminants, horses, and pigs 間質性著床 (interstitial) rats and mice humans, and guinea pigs

Interstitial implantation間質性著床: -步驟： -Invade侵入 -Ingestive吞食 -Digestive消化 -E 6 ~ E 11 -Trophoblast 滋養層 -Syncytiotrophoblast

Interstitial implantation間質性著床: -步驟： -Invade侵入 -Ingestive吞食 -Digestive消化 -E 6 ~ E 11 -Trophoblast 滋養層 -Syncytiotrophoblast -Cytotrophoblast -Inner cell mass (embryoblast)胚球層 bilaminar embryonic disc雙層胚盤

Trophoblast滋養層 : -Cytotrophoblast細胞滋養層 -Syncytiotrophoblast合體滋養層 -EPF (early pregnancy factor)早期妊娠因子 -24～ 48 hr -- 10 days

Trophoblast滋養層 : -Cytotrophoblast細胞滋養層 -Syncytiotrophoblast合體滋養層 -EPF (early pregnancy factor)早期妊娠因子 -24～ 48 hr -- 10 days -In mothernal serum -h. CG人類絨毛性腺激素 -10 days -In mother’s urine Embryoblast (inner cell mass) Hypoblast下胚層 (primary endoderm) h. CG corpus luteum progesterone 妊娠試驗： h. CG、EPF Inhibition of implantation -Diethylstilbestrol”事後丸” -RU 486”流產藥丸”

Intracytoplasmic sperm injection

Intracytoplasmic sperm injection

子宮外孕(ectopic pregnancies) Human Placenta previa前置胎盤 家畜：Antimesometrial 對子宮系膜

子宮外孕(ectopic pregnancies) Human Placenta previa前置胎盤 家畜：Antimesometrial 對子宮系膜

Day 8 Inner cell mass Bilaminar disc雙層胚盤 Hypoblast下胚層 Epiblast上胚層 Amnion羊膜 +Epiblast上胚層 Amnoitic cavity羊膜腔 Hypoblast下胚層

Day 8 Inner cell mass Bilaminar disc雙層胚盤 Hypoblast下胚層 Epiblast上胚層 Amnion羊膜 +Epiblast上胚層 Amnoitic cavity羊膜腔 Hypoblast下胚層 exocoelomic membrane外胚腔膜 Blastocytic cavity囊胚腔 Exocoelomic cavity外胚腔腔室 (primary yolk sac初級卵黃囊)

Day 9 Extraembryonic mesoderm胚外中胚層 Syncytiotrophoblast Lacuna陷窩

Day 9 Extraembryonic mesoderm胚外中胚層 Syncytiotrophoblast Lacuna陷窩

Day 10 - 12 Lacunar lacunar network Syncytiotrophoblast ↓ Endomatrial stromal cell Decidual cell蛻膜細胞

Day 10 - 12 Lacunar lacunar network Syncytiotrophoblast ↓ Endomatrial stromal cell Decidual cell蛻膜細胞 => decidual reaction蛻膜反應 Extraembryonic mesoderm胚外中胚層 Extraembryonic coelomic space胚外體空隙

Closing plug閉鎖栓

Closing plug閉鎖栓

Decidual cell蛻膜細胞

Decidual cell蛻膜細胞

Day 13 Extraembryonic mesoderm胚外中胚層 Extraembryonic coelomic space胚外體空隙 extraembryonic coelom胚外體腔 Extraembryonic somatic mesoderm胚外壁層中胚層 Extraembryonic splanchnic

Day 13 Extraembryonic mesoderm胚外中胚層 Extraembryonic coelomic space胚外體空隙 extraembryonic coelom胚外體腔 Extraembryonic somatic mesoderm胚外壁層中胚層 Extraembryonic splanchnic mesoderm胚外臟層中胚層 Chorion絨毛膜 -Extraembryonic somatic mesoderm -Cytotrophoblast -Syncytiotrophoblast Extraembryonic coelom胚外體腔 Chorionic cavity絨毛膜腔

Day 14 Primary yolk sac Secondary yolk sac Remnant of primary yolk sac Cytotrophoblast

Day 14 Primary yolk sac Secondary yolk sac Remnant of primary yolk sac Cytotrophoblast Primary chorionic villus初級絨毛膜絨毛 Hypoblast Prechordal plate脊索前板