Clarification dendritic branchlike Dendritic form of platelet Dendritic
Clarification: dendritic = branch-like Dendritic form of platelet Dendritic cell
The activated platelet (dendritic platelet) Food and Public Health 2015, 5(1): 1 -9
ADP Vascular and Endovascular Surgery Volume 40, Number 4, 2006
G-protein coupled receptors ADP receptor inhibition by clopidogrel http: //www. imtech. res. in/raghava/adpint/
G-protein coupled receptors Diphenhydramine (Benadryl) Ø Histamine H 1 receptor Atropine (Isopto Atropine) Ø Muscarinic acetylcholine receptor
G-protein coupled receptors Why do all G-protein-coupled receptors have 7 transmembrane domains?
G-protein activation GDP GTP
G-protein coupled receptors
Types of G proteins https: //www. slideshare. net/prashantshukla 927/gpcr-58146894
Adenylyl cyclase activation by Gs Kinase definition ? : Figure 15. 33 of B Alberts, A Johnson, J Lewis, M Raff, K Roberts and P Walter “Molecular Biology of the Cell” fourth edition 2002, Garland Science
Protein kinases
Allosteric changes
Protein kinase cascades Figure 15. 33 of B Alberts, A Johnson, J Lewis, M Raff, K Roberts and P Walter “Molecular Biology of the Cell” fourth edition 2002, Garland Science
Types of G proteins https: //www. slideshare. net/prashantshukla 927/gpcr-58146894
Adenylyl cyclase inhibition by Gi Figure 15. 33 of B Alberts, A Johnson, J Lewis, M Raff, K Roberts and P Walter “Molecular Biology of the Cell” fourth edition 2002, Garland Science
Types of G proteins https: //www. slideshare. net/prashantshukla 927/gpcr-58146894
Phospholipase C activation by Gq
Membrane derived phospholipids
Phosphatidylinositol
Phospholipase C activation Figure 15. 36 of B Alberts, A Johnson, J Lewis, M Raff, K Roberts and P Walter “Molecular Biology of the Cell” fourth edition 2002, Garland Science
The activated platelet (dendritic platelet) Food and Public Health 2015, 5(1): 1 -9
https: //www. youtube. com/watch? v=ZBSo_GFN 3 q. I
G-protein coupled receptors 1. In what type of tissue is the receptor expressed? 2. What type of Ga subunit is coupled to the receptor ? 3. What is the enzyme impacted by the Ga-GTP formed by the activated receptor? 4. What is a major physiological effect of the receptor being activated? Apollo: thromboxane receptor Zeus: histamine H 1 receptor Artemis: rhodopsin Mars: serotonin receptor (5 -hydroxytryptamine or 5 -HT receptor) Gaia: m opioid receptor Poseidon: cannabinoid receptor Extra A: dopamine receptor Extra B: acetylcholine muscarinic receptor
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