citric acid cycle Aerobic NADH and Pyruvate Alcohol
心智圖 citric acid cycle Aerobic NADH and Pyruvate Alcohol Fermentation Anaerobic Lactic Acid Fermentation Glucose Glycolysis Mannose Fructose Galactose Glycerol The Leloir pathway galactose-1 -phosphate uridylyltransferase
POINT 1 n n The fate of NADH and Pyruvate 當細胞處於Aerobic時,NADH和Pyruvate自 然地進入Krebs Cycle,但當細胞在anaerobic 時,此時過多NADH和Pyruvate該何去何從 呢?
Anaerobic Respiration n Anaerobic Respiration分為兩種: (1)Alcohol Fermentation(發酵) 藉由 Alcohol dehydrogenase 將NADH 氧化,重新生成NAD+ (2)Lactic Acid Fermentation 藉由 lactate dehydrogenase 將NADH 氧化,重新生成NAD+
Anaerobic Respiration n Alcohol Fermentation
Anaerobic Respiration n Lactic Acid Fermentation
POINT 2 n Are Substrates Other Than Glucose Used in Glycolysis? n 難道只有Glucose才能夠進行Glycolysis嗎? 那其他種類的醣就不行嗎?
1 )Mannose, 2)galactose, 3)fructose, 同樣也能夠進入 Glycolysis喔!
The Leloir pathway n 其中最有趣的為Galactose(半乳糖) metabolism the Leloir pathway n The galactose-1 -phosphate uridylyltransferase 的反應包含了 “ping-pong” kinetic mechanism.
The Leloir pathway
“ping-pong” kinetic mechanism
Glycerol 也能夠進入 Glycolysis
習題解析 n Why human use Lactic acid fermentation mainly but not Alcohol fermentation? A:因為藉由Alcohol fermentation作用會產 生CO 2,而CO 2在溶入血液後形成H 2 CO 3(aq) 會影響血液中p. H值濃度,並進一步影響個 體的生理反應;而Lactic acid fermentation所 產生之Lactic acid可被人體細胞代謝。
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