circ. RNA结构 结构的发现以及证实: Canonical 正常的链状RNA Scramble 混乱的RNA结构 (circ. RNA) RNase. R:RNA剪切酶R Julia Salzman, Charles Gawad PLosone 1. Feb 2012
circ. RNA功能 最新Nature上两项研究都将焦点放在了由大约 1500个核苷酸构成的一个环状大 RNA上,存在于哺乳动物的脑细胞中。这些环状RNA可以阻断mi. R-7的调节作用。 类似的研究也有关小鼠性别决定基因等的研究。 ☆mi. R-7 is a key regulator of various cancer pathways ☆implication of mi. R-7 in Parkinson’s disease by direct targeting of α-synuclein protein expression ☆ci. RS-7 probably serves as a crucial factor significantly engaged in the functioning of neurons as well as a responsible candidate in neurological disorders and brain tumour development. mi. RNA-7 Attenuation in Schwannoma Tumors Stimulates Growth by Upregulating Three Oncogenic Signaling Pathways December 13, 2010 Cancer Reach
circ. RNA功能 作机制: 如ci. Rs-7与mi. R-7有超过71个结合位点。 Natural RNA circles function as efficient micro. RNA sponges Nature LETTER 2013. 3