Chromeleon 7 1 The ProductivityBoosting Chromatography Software Jim

Chromeleon 7. 1: The Productivity-Boosting Chromatography Software Jim Schibler Senior Staff Product Manager 31 May 2012

Outline • Reflections on productivity • Productivity tools of Chromeleon 7. 1 • A look to the future

Reflections on Productivity 3

What is Productivity? • In general: Output / Input • In lab context: Results delivered per resources used • Resources: • Samples • Instruments • Personnel • Eluents, standards, reagents • Computing resources • Time is often the most critical resource

Factors Affecting Data System Productivity • Computer hardware • Network factors • Software design • Concurrent tasks (number and complexity) • User-system interaction Usability is often the most important factor

The User's Perspective I am an analytical chemist. I need to know: • what it is • how much there is • how sure I am The easier you make it for me to know these three things, the happier I’ll be. — Steve Steiner, circa 1995

The User's Perspective It's Just a Tool!

Productivity Tools of Chromeleon 7. 1 8

Some Productivity Features of Chromeleon 7. 1 • Modern user interface • e. Workflows • Mini. Plots • Queries • Interactive Dynamic Displays • Cobra and Smart. Peaks • Result Charting • Virtual Column Separation Simulator

Chromeleon 7 User Interface: General Principle "Operational Simplicity" • Minimize number of steps needed to perform any task • Make all steps easy to understand easy to perform • Minimize time needed to perform any task

Design Principles to Achieve Operational Simplicity 1. Follow conventions of ubiquitous software 2. Organize in a layered format 3. Maintain consistency 4. Provide contextual clues to keep the user oriented 5. Use fonts discreetly to classify and differentiate 6. Use graphical elements to communicate information quickly 7. Use clear, consistent terminology 8. Implement best practices for error handling 9. Minimize visual distractions

Chromatography Process Chromeleon 7 All chromatography manages the steps in startswith ends withresults samples between 21

Easier, More Reliable Operation using e. Workflows 3. Sequence is created and can be immediately run 1. Choose e. Workflow, select Instrument, click “Launch” 2. Specify number of samples and first sample's position

Easier, More Reliable Operation using e. Workflows e. Workflow can also cover: • Data analysis • Report generation • Electronic signature options

Mini. Plots Confirm that data were collected Check for presence or absence of peaks Confirm that peaks were separated Compare peak profiles of injections

Injection Queries Quick Search Criteria Computed Criteria Number of Items Found Instant Sort, Filter, Group, Find tools Results (with Mini. Plots)

Interactive Dynamic Displays Chromatogram Calibration Plot Consistent appearance and behaviors for raw data plots Injection List Interactive Results Associated Objects

Cobra™ Peak Detection Algorithm 1. Start Cobra Wizard 2. Define the integration range 3. Select the narrowest peak to be integrated 4. Select the smallest peak of interest to be Integrated

Cobra™ Peak Detection Algorithm And Your Integration Is Done!

Smart. Peaks™ Integration Assistant 1. Activate Smart. Peaks Wizard 2. Select Area of Interest 3. Select Integration You Want

Smart. Peaks™ Integration Assistant And Your Integration Is Done!

Result Charting • • • Instant charting of result data Dynamically linked to source data Templates for common tasks Fully customizeable Available for interactive views and report templates

Interactive Charts • Click any injection, peak, or chart point – all items update accordingly Chart shows results of selected peak Selected Injection is indicated in the chart

Virtual Column Separation Simulator • Reveals optimum separation. Select conditions without any lab work! Analytes Resolution Map Select Methodology and Column Virtual Chromatogram

Virtual Column Separation Simulator • Many of these analytes coelute on popular AS 14 anion column

Virtual Column Separation Simulator • Learn quickly that no carbonate column can resolve these analytes

Virtual Column Separation Simulator • AS 18 gradient provides baseline separation in under 30 minutes

Summary • Lab productivity = going from samples to results efficiently • Chromeleon 7. 1 provides unique, powerful tools that get you from samples to results more efficiently • Future releases will continue to deliver improved tools that enable further increases in productivity

Thank you!