CHRISTOPHER BROWNE MD ADVANCED ORTHOPEDICS OF OKLAHOMA TOTAL
CHRISTOPHER BROWNE, MD ADVANCED ORTHOPEDICS OF OKLAHOMA TOTAL JOINT RECONSTRUCTION HIP AND KNEE
STEMCELL INJECTION THERAPYHYPE OR FOR REAL?
STEM CELLS Why do we care?
SNAKE OIL OR SCIENCE
SNAKE OIL Big Money Placebo
SCIENCE While emerging therapies have shown promise to reduce pain and improve function which is bright for the future, a current product proven to regenerate damaged/diseased skeletal tissue in humans does not exist today.
SCIENCE It’s not about how much you can charge patients but how you can offer the best, scientifically proven, reasonably priced options to those entrust their care to us.
WHAT WORKED IN THE PAST Corticosteriods Hyaloronic Acid
CORTICOSTERIODS Interrupt Inflammatory Cascade Immunosuppresive effects
CORTICOSTERIOD ADVANTAGES Scientifically proven anti-inflammatory effects Pain relief Safe Cheap
CORTICOSTERIOD DISADVANTAGES No long term effects Degenerative not regenerative
HYALORONIC ACID/VISCO SUPPLEMENTATION HA one of main components of joint fluid and cartilage matrix. Improves articular cartilage biochemistry resulting in reduced inflammation, improved lubrication and decreased effusions.
HYALORONIC ACID ADVANTAGES Anti-inflammatory Lubrication Safe
HYALORONIC ACID DISADVANTAGES Not Regenerative Just a patch
ORTHOBIOLOGICS Human derived products used to treat orthopedic malalies.
PLATELET RICH PLASMA-PRP Autologous concentration of human platelets in a small volume. Lots of growth factors Augments natural healing process through many growth factors.
PRP ADVANTAGES Anti-inflammatory Better than others Safe Good results for arthritis
PRP DISADVANTAGES Not Regenerative $
WHAT IS A STEM CELL? True Stemcell-Pluripotent Adult Stemcell-Multi-potent
WHAT ARE THE OPTIONS Adult Stem Cells � Amniotic Derived Treatments � Adipose/Bone Marrow Stem Cell Treatments
AMNIOTIC-DERIVED TREATMENTS Amniotic membrane derived cells after c-section Highly processed Limited cells but lots of beneficial factors
AMNIOTIC DERIVED TREATMENT ADVANTAGES Safe Anti-inflammatory
AMNIOTIC DERIVED TREATMENT DISADVANTAGES Regenerative? Limited Studies $$
ADIPOSE/BONE MARROW DERIVED STEM CELLS Harvested from cadaver or live person Processed Growth Factors +/- cells
ADIPOSE/BONE MARROW DERIVED STEM CELLS ADVANTAGES Safe? Anti-inflammatory
ADIPOSE/BONE MARROW DERIVED STEM CELLS DISADVANTAGES Painful acquisition Regenerative $$
HOW CAN THEY BE USED?
ORTHO BIOLOGICS FOR BONE HEALING Fractures Bone and tendon healing
ORTHO BIOLOGICS LIGAMENT REPAIR Augmentation Anti-inflammatory
ORTHO BIOLOGICS FOR SMALL CARTILAGE DEFECT Promising results
ORTHO BIOLOGICS FOR ARTHRITIS Safe and effective up to 2 years
WHAT NEEDS TO BE DONE? Science!
WHO SHOULD BE TREATING PATIENTS?
QUESTIONS?
THE END THANK YOU!
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