CHIC DNA Repository CHIC DNA Repository MISSION The

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CHIC DNA Repository

CHIC DNA Repository

CHIC DNA Repository • MISSION – The CHIC DNA Repository, co-sponsored by the OFA

CHIC DNA Repository • MISSION – The CHIC DNA Repository, co-sponsored by the OFA and the AKC CHF, collects and stores canine DNA samples along with corresponding Genealogic and Phenotypic information to facilitate future research

CHIC DNA Repository • OBJECTIVES – Facilitate more rapid research progress by expediting the

CHIC DNA Repository • OBJECTIVES – Facilitate more rapid research progress by expediting the sample collection process – Provide researchers with optimized family groups needed for research – Allow breeders to take advantage of future DNA based disease tests as they become available – Foster a team environment between breeders and the research community improving the likelihood of genetic discovery

CHIC DNA Repository • AKC Delegates Meeting, Sept ’ 05 – Dr. Elaine Ostrander,

CHIC DNA Repository • AKC Delegates Meeting, Sept ’ 05 – Dr. Elaine Ostrander, AKC DNA Consultant, answers questions from the floor…”Besides money, what is the most important thing we can do to assist research efforts…” – Response: “PROVIDE SAMPLES”

CHIC DNA Repository • Need for Education re: DNA – AKC DNA Program •

CHIC DNA Repository • Need for Education re: DNA – AKC DNA Program • • • Imports Field Inspections Multiple Sired Litters Frequently Used Sire Parentage Verification / Stud Book Integrity – Versus DNA for Health Research Purposes

CHIC DNA Repository • Blood versus Swab Solution – Blood • • • Higher

CHIC DNA Repository • Blood versus Swab Solution – Blood • • • Higher Yield Better Quality Works with all scientific applications Invasive High Cost Limited Participation – Swabs • • • Low Cost Non Invasive Greater Participation Decreased Yield New Technology requires less quantity

CHIC DNA Repository • Dual Solution…Blood or Swab – Blood • University of Missouri,

CHIC DNA Repository • Dual Solution…Blood or Swab – Blood • University of Missouri, Dr. Gary Johnson’s Lab – Swabs • University of California – Davis, Veterinary Genetics Lab, contacts: Dr. Mark Neff & Dr. Alison Ruhe

CHIC DNA Repository • Pilot Program – 6 Months – Golden Retriever Club of

CHIC DNA Repository • Pilot Program – 6 Months – Golden Retriever Club of America – Sample, Genealogy, Health History collected on nearly 1, 000 dogs – Mix of healthy / affected dogs • Heart Murmurs, Hemangiosarcoma, Fibrosarcoma, Mast Cell Tumors, Hypothyroid, Cataracts, Hip & Elbow Dysplasia

CHIC DNA Repository • • 24 Months Later 3000+ dogs 60 breeds 2 approved

CHIC DNA Repository • • 24 Months Later 3000+ dogs 60 breeds 2 approved application for samples – MBT – Lens Luxation – GR – Mast Cell Tumor • 4 clubs have facilitated transfer of samples from existing banks to CHIC (Miniature Bull Terriers, Otterhounds, Field Spaniels, Poodles) • National Specialty DNA Clinics

 • Contact Info: – Eddie Dziuk, OFA, edziuk@offa. org (573) 442 -0418 x

• Contact Info: – Eddie Dziuk, OFA, edziuk@offa. org (573) 442 -0418 x 222 – Erika Werne, AKC CHF, eaw@akcchf. org (888) 682 -9696 • Questions?