chemists Molecular things you have Molecular things you

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chemists Molecular things you have ? Molecular things you want

chemists Molecular things you have ? Molecular things you want

Molecular things you have Nam Le Molecular things you want

Molecular things you have Nam Le Molecular things you want

Synthesis Requires Two Things 1. a library of reactions 2. a strategy or plan

Synthesis Requires Two Things 1. a library of reactions 2. a strategy or plan for combining known reactions to reach the desired target molecule 3. and a little luck always helps

goal (a desired molecular structure)

goal (a desired molecular structure)

Work the problem from the final goal toward the reactants. goal subgoal-1 a subgoal-2

Work the problem from the final goal toward the reactants. goal subgoal-1 a subgoal-2 a Have a library of reactions that connect a goal to a subgoal-1 b subgoal-2 b subgoal-3 a subgoal-3 b

Work the problem from the final goal toward the reactants. Have a library of

Work the problem from the final goal toward the reactants. Have a library of reactions that connect a goal to a subgoal. Using your knowledge of each reaction select the best pathway as your solution to the synthetic problem.

Work the problem from the final goal toward the reactants. Have a library of

Work the problem from the final goal toward the reactants. Have a library of reactions that connect a goal to a subgoal. Using your knowledge of each reaction select the best pathway as your solution to the synthetic problem.

Discodermolide The result of biological studies stimulated considerable interest in discodermolide as a possible

Discodermolide The result of biological studies stimulated considerable interest in discodermolide as a possible immunosuppressant. Subsequently studies demonstrated discodermolide is a potent cell growth inhibitory agent, which arrests cell development at the M phase by binding and stabilizing mitotic spindle microtubules. Thus, the ability of (+)-1 to inhibit cell growth was suggested to resemble the clinically proven anticancer agent Taxol.

Discodermolide isolated from a marine sponge

Discodermolide isolated from a marine sponge

Discodermolide Some problems with pharmaceuticals from natural sources: Quantities can be very limited. The

Discodermolide Some problems with pharmaceuticals from natural sources: Quantities can be very limited. The isolation process can be very expensive. Industrial production can destroy valuable ecosystems. More active structural variants are not available from nature.

Discodermolide Some problems with pharmaceuticals from natural sources: Quantities can be very limited. The

Discodermolide Some problems with pharmaceuticals from natural sources: Quantities can be very limited. The isolation process can be very expensive. Industrial production can destroy valuable ecosystems. More active structural variants are not available from nature.

Discodermolide isolated from a marine sponge

Discodermolide isolated from a marine sponge

Discodermolide chemical synthesis available chemicals

Discodermolide chemical synthesis available chemicals

Discodermolide chemical synthesis

Discodermolide chemical synthesis

commercially available

commercially available

General Scheme of a new reaction:

General Scheme of a new reaction:

Example. : muscalure, the sex attractant of the common housefly

Example. : muscalure, the sex attractant of the common housefly

General Reaction Scheme of a new reaction:

General Reaction Scheme of a new reaction:

Problems in synthetic chemistry Work the problem from the final goal toward the reactants.

Problems in synthetic chemistry Work the problem from the final goal toward the reactants. Have a library of reactions that connect a goal to a subgoal. Using your knowledge of each reaction select the best pathway as your solution to the synthetic problem.