chemists Molecular things you have Molecular things you

Molecular things you have Nam Le Molecular things you want

Synthesis Requires Two Things 1. a library of reactions 2. a strategy or plan

Work the problem from the final goal toward the reactants. goal subgoal-1 a subgoal-2

Work the problem from the final goal toward the reactants. Have a library of

Discodermolide The result of biological studies stimulated considerable interest in discodermolide as a possible

Discodermolide isolated from a marine sponge

Discodermolide Some problems with pharmaceuticals from natural sources: Quantities can be very limited. The

Discodermolide chemical synthesis available chemicals

Example. : muscalure, the sex attractant of the common housefly

General Reaction Scheme of a new reaction:

Problems in synthetic chemistry Work the problem from the final goal toward the reactants.

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chemists Molecular things you have ? Molecular things you want

Molecular things you have Nam Le Molecular things you want

Synthesis Requires Two Things 1. a library of reactions 2. a strategy or plan for combining known reactions to reach the desired target molecule 3. and a little luck always helps

goal (a desired molecular structure)

Work the problem from the final goal toward the reactants. goal subgoal-1 a subgoal-2 a Have a library of reactions that connect a goal to a subgoal-1 b subgoal-2 b subgoal-3 a subgoal-3 b

Work the problem from the final goal toward the reactants. Have a library of reactions that connect a goal to a subgoal. Using your knowledge of each reaction select the best pathway as your solution to the synthetic problem.

Discodermolide The result of biological studies stimulated considerable interest in discodermolide as a possible immunosuppressant. Subsequently studies demonstrated discodermolide is a potent cell growth inhibitory agent, which arrests cell development at the M phase by binding and stabilizing mitotic spindle microtubules. Thus, the ability of (+)-1 to inhibit cell growth was suggested to resemble the clinically proven anticancer agent Taxol.

Discodermolide isolated from a marine sponge

Discodermolide Some problems with pharmaceuticals from natural sources: Quantities can be very limited. The isolation process can be very expensive. Industrial production can destroy valuable ecosystems. More active structural variants are not available from nature.

Discodermolide isolated from a marine sponge

Discodermolide chemical synthesis available chemicals

Discodermolide chemical synthesis

commercially available

General Scheme of a new reaction:

Example. : muscalure, the sex attractant of the common housefly

General Reaction Scheme of a new reaction:

Problems in synthetic chemistry Work the problem from the final goal toward the reactants. Have a library of reactions that connect a goal to a subgoal. Using your knowledge of each reaction select the best pathway as your solution to the synthetic problem.