Chemical Risk Assessment Exposure Monitoring Chemical Production Development

Chemical Risk Assessment & Exposure Monitoring Chemical Production & Development Janssen Pharma Geel Belgium February 2010 Michel Vangeel - Prevention Department

Overview 2 1. Introduction - setting 2. Approach Risk Assessments 3. Approach Baseline Sampling Plan 4. RBEAP

Situate IH in Chemical Production l l l Different chemical agents: risks, amounts Different periodicity Different sizes of campaigns l Similar production equipment l Activities / processes l l 3 Single purpose / multi purpose Different processes (> 300): intermediates & final products

4

Integration of IH risk identification, -evaluation and control in chemical processes New Process Introduction / transfer CHA / PHR IH risk identification model (part of PHA) Integration in general baseline sampling plan Apply sampling rationale: annual / long term Select process: start sampling campaign Long term monitoring Control monitoring Sampling results: IH report Results not OK Results OK Short term Administrative controls: - PPE - Respiratory Protection Program - Safe Behaviour Technical controls: - Quick fixes 5 long term Site projects: - Strategic Master Plan PBOEL - Strategic Master Plan solvents

Approach Risk Assessments l Processes: SOP-Geel-274 - Chemical Hazard Analyses: the process risk evaluation - Process Hazard Analyses: the process in the installation / department IH risk identification model integrated - Process Hazard Review Periodic Review 6

IH Risk Identification model Processes l l 7 Summary process description + authors + date Risk Identification model Flow: - part of PHA/PHR - prepared by production & EHS - reviewed by PHA-team - summary in PHA document Carcinogens: additional evaluation flow - SWIFT

IH Risk Identification model Summary Process Description 8

IH Risk Identification model IH Risk Assessment - judgement exposure 9

IH Risk Identification model Clarification 10

IH Risk Identification model Activities l For each department QA, Warehouse, Environmental Department 11 l Evaluation tasks l Review: 3 years / MOC

Baseline Sampling Plan l IH Risk Identification models l Baseline Sampling Plan = overview of all moderate & high risks = API / Gases & vapours l 12 Sheets - rationale approach setting up sampling plan - overview / department

Baseline Sampling Plan Example API Plant 1 Reference IH reports IH critical activities Processes PBOEL/API Sampling method available 13 Current status baseline sampling

Baseline Sampling Plan Risk Calculation Gases & Vapours l l l 14 Need to make selection / each IH critical task Risk Calculation: - COSHH essentials - Vapour pressure - TLV Update December 2010: Now, we no longer take TLV into account to select worst case to sample (see more info in RBEAP-approach) Separate list chemical agents

Baseline Sampling Plan Risk Calculation Gases & Vapours 15

Baseline Sampling Plan Example Gases & Vapours Plant 2 Reference IH reports IH critical activities Processes Risk Prior Current status baseline sampling 16

Risk Based Evaluation Assessment Protocol Inventory 17

RBEAP Document 18

Sampling Plan Additional evaluations New installations l Fugitive emission monitoring program l Accidental release gases & vapours l Specific preparations / process l + Pressure control installation + PID, FID, Portable IR l 19 Ad random: + IH forum: meeting with Union Representatives + Company Physician + Department Manager + Safety & IH Manager

Sampling Plan Additional evaluations IH monitoring: pump / absorbent Leak detection Short term exposure Fixed monitoring 20

Questions 21