Chapter 6 Antispasmodics and muscular relexants Pharmacodynamic Mechanism

Chapter 6 Antispasmodics and muscular relexants

Pharmacodynamic Mechanism 自主神经系统是指调节内脏功能的神经装置，也可称为植物性 神经系统或内脏神经系统。实际上，自主神经系统还是受中枢 神经系统控制的，并不是完全独立的，自主神经系统仅支配内 脏的传出神经，不包括传入神经。 Autonomic nervous system is the neural regulation of visceral function devices, may also be known as the plant or visceral nervous system. In fact, the autonomic nervous system is controlled by the central nervous system and is not fully independent. Autonomic nervous system only control visceral efferent nerve, excluding afferent nerve.

The biosynthesis of acetylcholine Receptor E ACh. E

Anticholinergic drugs Muscarinic receptor blocking agents： Atropa belladonna alkaloids ：atropine，scopolamine， anisodamine，anisodine N 1 receprot blocking agents：美卡拉明，六甲溴铵 N 2 receprot blocking agents

Scopolamine butylbromide 1. soluble in chloroform and water, slightly soluble in ethanol. 2. has the characteristics reaction of tropic acid. 3. quaternary ammonium compounds of scopolamine with the weak central nervous system function and being peripheral anticholinergic drugs for spasticity, such as the gastrointestinal tract. 4. Oral non-absorption, intramuscular injection or intravenous administration。 （1 S, 3 S, 5 R, 6 R, 7 S, 8 S）-6, 7 -环氧-8 -丁基-3（S）-环氧托烷基托 哌溴化物

SAR of M receptor antagonists Aminoethanol ester be considered as the basic activity structure.

Central musclar relaxants • Within the central block the neurons transmission impulse in the central nervous system, relax the skeletal muscle. • Chlorzoxazone: for the treatment of skeletal muscle diseases and muscle pain.

阿曲库铵苯磺酸盐 Symmetric 1 – benzyltetrahydro Isoquinoline drugs, double amine structure 4 chiral carbons, a mixture of isomers Represents the Hofmann elimination and ester degradation metabolism, slight side effects

泮库溴铵 1，1′-[3 a，17 b-双-（乙酰氧基）-5 a-雄甾烷-2 b，16 b-二基] 双-[1 -甲基哌啶鎓]二溴化物 With androgenic nucleus, but no androgen activity. Both ring A and ring D with the structure of acetylcholine-like fragment Drug for major surgery Steroid non-depolarizing neuromuscular blocker