Chapter 43 Ultradian Rhythms Copyright 2016 Elsevier Inc

Figure 43. 1: Ultradian rhythm of corticosterone in the rat. The data represent an

Figure 43. 2: Gene pulsing in response to ultradian corticosterone administration. Pulses of corticosterone

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Figure 43. 1: Ultradian rhythm of corticosterone in the rat. The data represent an example of 24 -h corticosterone profile of plasma from adult male rat. Shaded region indicates the dark phase. Under basal (i. e. , unstressed) conditions, corticosterone levels are characterized by an ultradian rhythm of near-hourly pulses of hormone secretion during the 24 -h cycle. Shaded region indicates the dark phase. Data adapted from Walker JJ, Spiga F, Waite E, et al. The origin of glucocorticoid hormone oscillations. PLo. S Biol. 2012; 10(6): e 1001341. http: //dx. doi. org/10. 1371/journal. pbio. 1001341. Copyright © 2016 Elsevier Inc. All rights reserved.

Figure 43. 2: Gene pulsing in response to ultradian corticosterone administration. Pulses of corticosterone delivered (arrows) to adrenalectomized rats by intravenous injection produces cycles in plasma hormone concentration (red), liver GR DNA binding measured by Trans. AM DNA-binding ELISA (blue), and bursts of liver Per 1 nascent RNA transcription (green) associated with the pulse peaks. Redrawn from data in Stavreva DA, Wiench M, John S, et al. Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription. Nat Cell Biol. 2009; 11(9): 1093– 1102. http: //dx. doi. org/10. 1038/ncb 1922. Copyright © 2016 Elsevier Inc. All rights reserved.