CHAPTER 2 Pharmacologic Principles Mosby items and derived
![CHAPTER 2 Pharmacologic Principles Mosby items and derived items © 2005, 2002 by Mosby, CHAPTER 2 Pharmacologic Principles Mosby items and derived items © 2005, 2002 by Mosby,](https://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-1.jpg)
CHAPTER 2 Pharmacologic Principles Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Drug Any chemical that affects the physiologic processes of a living organism Mosby items Drug Any chemical that affects the physiologic processes of a living organism Mosby items](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-2.jpg)
Drug Any chemical that affects the physiologic processes of a living organism Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacology The study or science of drugs Mosby items and derived items © 2005, Pharmacology The study or science of drugs Mosby items and derived items © 2005,](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-3.jpg)
Pharmacology The study or science of drugs Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Drug Names Chemical name • Describes the drug’s chemical composition and molecular structure Generic Drug Names Chemical name • Describes the drug’s chemical composition and molecular structure Generic](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-4.jpg)
Drug Names Chemical name • Describes the drug’s chemical composition and molecular structure Generic name (nonproprietary name) • Name given by the United States Adopted Name Council Trade name (proprietary name) • The drug has a registered trademark; use of the name restricted by the drug’s patent owner (usually the manufacturer) Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Drug Names (cont'd) Chemical name • (+/-)-2 -(p-isobutylphenyl) propionic acid Generic name • ibuprofen Drug Names (cont'd) Chemical name • (+/-)-2 -(p-isobutylphenyl) propionic acid Generic name • ibuprofen](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-5.jpg)
Drug Names (cont'd) Chemical name • (+/-)-2 -(p-isobutylphenyl) propionic acid Generic name • ibuprofen Trade name • Motrin®, Advil® Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacologic Principles • • • Pharmaceutics Pharmacokinetics Pharmacodynamics Pharmacotherapeutics Pharmacognosy Mosby items and derived Pharmacologic Principles • • • Pharmaceutics Pharmacokinetics Pharmacodynamics Pharmacotherapeutics Pharmacognosy Mosby items and derived](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-6.jpg)
Pharmacologic Principles • • • Pharmaceutics Pharmacokinetics Pharmacodynamics Pharmacotherapeutics Pharmacognosy Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmaceutics The study of how various drug forms influence pharmacokinetic and pharmacodynamic activities Mosby Pharmaceutics The study of how various drug forms influence pharmacokinetic and pharmacodynamic activities Mosby](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-7.jpg)
Pharmaceutics The study of how various drug forms influence pharmacokinetic and pharmacodynamic activities Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Figure 2 -1 The chemical, generic, and trade names for the common analgesic ibuprofen Figure 2 -1 The chemical, generic, and trade names for the common analgesic ibuprofen](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-8.jpg)
Figure 2 -1 The chemical, generic, and trade names for the common analgesic ibuprofen are listed next to the chemical structure of the drug. Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacokinetics • The study of what the body does to the drug – Absorption Pharmacokinetics • The study of what the body does to the drug – Absorption](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-9.jpg)
Pharmacokinetics • The study of what the body does to the drug – Absorption – Distribution – Metabolism – Excretion Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacodynamics • The study of what the drug does to the body – The Pharmacodynamics • The study of what the drug does to the body – The](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-10.jpg)
Pharmacodynamics • The study of what the drug does to the body – The mechanism of drug actions in living tissues Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Figure 2 -2 Phases of Drug Activity. (From Mc. Kenry LM, Salerno E: Mosby’s Figure 2 -2 Phases of Drug Activity. (From Mc. Kenry LM, Salerno E: Mosby’s](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-11.jpg)
Figure 2 -2 Phases of Drug Activity. (From Mc. Kenry LM, Salerno E: Mosby’s pharmacology in nursing—revised and updated, ed 21, St. Louis, 2003, Mosby. ) Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacotherapeutics The use of drugs and the clinical indications for drugs to prevent and Pharmacotherapeutics The use of drugs and the clinical indications for drugs to prevent and](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-12.jpg)
Pharmacotherapeutics The use of drugs and the clinical indications for drugs to prevent and treat diseases Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacognosy The study of natural (plant and animal) drug sources Mosby items and derived Pharmacognosy The study of natural (plant and animal) drug sources Mosby items and derived](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-13.jpg)
Pharmacognosy The study of natural (plant and animal) drug sources Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacokinetics: Absorption • The rate at which a drug leaves its site of administration, Pharmacokinetics: Absorption • The rate at which a drug leaves its site of administration,](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-14.jpg)
Pharmacokinetics: Absorption • The rate at which a drug leaves its site of administration, and the extent to which absorption occurs – Bioavailability – term used to quantify extent of drug absorption – Bioequivalent - Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Factors That Affect Absorption • • Administration route of the drug Food or fluids Factors That Affect Absorption • • Administration route of the drug Food or fluids](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-15.jpg)
Factors That Affect Absorption • • Administration route of the drug Food or fluids administered with the drug Exercise Dosage formulation Status of the absorptive surface Rate of blood flow to the small intestine Acidity of the stomach Status of GI motility Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Routes • A drug’s route of administration affects the rate and extent of absorption Routes • A drug’s route of administration affects the rate and extent of absorption](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-16.jpg)
Routes • A drug’s route of administration affects the rate and extent of absorption of that drug – Enteral (GI tract) • Oral • rectal – Parenteral • IV, IM – Topical • skin Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Enteral Route • Drug is absorbed into the systemic circulation through the oral or Enteral Route • Drug is absorbed into the systemic circulation through the oral or](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-17.jpg)
Enteral Route • Drug is absorbed into the systemic circulation through the oral or gastric mucosa, the small intestine, or rectum – Oral – Sublingual – Buccal – Rectal Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![First-Pass Effect • The metabolism of a drug and its passage from the liver First-Pass Effect • The metabolism of a drug and its passage from the liver](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-18.jpg)
First-Pass Effect • The metabolism of a drug and its passage from the liver into the circulation – A drug given via the oral route may be extensively metabolized by the liver before reaching the systemic circulation (high first-pass effect) – The same drug—given IV—bypasses the liver, preventing the first-pass effect from taking place, and more drug reaches the circulation Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Figure 2 -3 First-pass effect is the metabolism of a drug by the liver Figure 2 -3 First-pass effect is the metabolism of a drug by the liver](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-19.jpg)
Figure 2 -3 First-pass effect is the metabolism of a drug by the liver before its systemic availability Box 2 -1 Drug Routes and First. Pass Effects Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Parenteral Route • Intravenous (fastest delivery into the blood circulation) • Intramuscular • Subcutaneous Parenteral Route • Intravenous (fastest delivery into the blood circulation) • Intramuscular • Subcutaneous](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-20.jpg)
Parenteral Route • Intravenous (fastest delivery into the blood circulation) • Intramuscular • Subcutaneous • Intradermal • Intrathecal • Intraarticular Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Topical Route • • • Skin (including transdermal patches) Eyes Ears Nose Lungs (inhalation) Topical Route • • • Skin (including transdermal patches) Eyes Ears Nose Lungs (inhalation)](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-21.jpg)
Topical Route • • • Skin (including transdermal patches) Eyes Ears Nose Lungs (inhalation) Vagina Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Distribution The transport of a drug in the body by the bloodstream to its Distribution The transport of a drug in the body by the bloodstream to its](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-22.jpg)
Distribution The transport of a drug in the body by the bloodstream to its site of action • • • Protein-binding Water soluble vs. fat soluble Blood-brain barrier Areas of rapid distribution: heart, liver, kidneys, brain Areas of slow distribution: muscle, skin, fat Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Metabolism (Also Known As Biotransformation) The biologic transformation of a drug into an inactive Metabolism (Also Known As Biotransformation) The biologic transformation of a drug into an inactive](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-23.jpg)
Metabolism (Also Known As Biotransformation) The biologic transformation of a drug into an inactive metabolite, a more soluble compound, or a more potent metabolite • • • Liver (main organ) Kidneys Lungs Plasma Intestinal mucosa Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Figure 2 -4 Drug transport in the body. (From Mc. Kenry LM, Salerno E: Figure 2 -4 Drug transport in the body. (From Mc. Kenry LM, Salerno E:](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-24.jpg)
Figure 2 -4 Drug transport in the body. (From Mc. Kenry LM, Salerno E: Mosby's pharmacology in nursing—revised and updated, ed 21, St. Louis, 2003, Mosby. ) Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Metabolism/Biotransformation • Biologic transformation of a drug into: – An inactive metabolite – A Metabolism/Biotransformation • Biologic transformation of a drug into: – An inactive metabolite – A](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-25.jpg)
Metabolism/Biotransformation • Biologic transformation of a drug into: – An inactive metabolite – A more soluble compound – A more potent metabolite Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Metabolism/Biotransformation (cont'd) – Organs or body tissues – Liver (main) – Skeletal muscle – Metabolism/Biotransformation (cont'd) – Organs or body tissues – Liver (main) – Skeletal muscle –](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-26.jpg)
Metabolism/Biotransformation (cont'd) – Organs or body tissues – Liver (main) – Skeletal muscle – Kidneys – Lungs – Plasma – Intestinal mucosa Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Metabolism/Biotransformation (cont'd) Factors that decrease metabolism • • • Cardiovascular dysfunction Renal insufficiency Starvation Metabolism/Biotransformation (cont'd) Factors that decrease metabolism • • • Cardiovascular dysfunction Renal insufficiency Starvation](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-27.jpg)
Metabolism/Biotransformation (cont'd) Factors that decrease metabolism • • • Cardiovascular dysfunction Renal insufficiency Starvation Obstructive jaundice Erythromycin or ketoconazole drug therapy Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Metabolism/Biotransformation (cont'd) Factors that increase metabolism • Barbiturates • Rifampin therapy Mosby items and Metabolism/Biotransformation (cont'd) Factors that increase metabolism • Barbiturates • Rifampin therapy Mosby items and](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-28.jpg)
Metabolism/Biotransformation (cont'd) Factors that increase metabolism • Barbiturates • Rifampin therapy Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Metabolism/Biotransformation (cont'd) Delayed drug metabolism results in: • Accumulation of drugs • Prolonged action Metabolism/Biotransformation (cont'd) Delayed drug metabolism results in: • Accumulation of drugs • Prolonged action](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-29.jpg)
Metabolism/Biotransformation (cont'd) Delayed drug metabolism results in: • Accumulation of drugs • Prolonged action of the drugs Stimulating drug metabolism causes: • Diminished pharmacologic effects Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Excretion The elimination of drugs from the body • Kidneys (main organ) • Liver Excretion The elimination of drugs from the body • Kidneys (main organ) • Liver](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-30.jpg)
Excretion The elimination of drugs from the body • Kidneys (main organ) • Liver • Bowel – Biliary excretion – Enterohepatic circulation Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Figure 2 -5 Renal drug excretion. The primary processes involved in drug excretion and Figure 2 -5 Renal drug excretion. The primary processes involved in drug excretion and](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-31.jpg)
Figure 2 -5 Renal drug excretion. The primary processes involved in drug excretion and the approximate location that these processes take place in the kidney are illustrated. Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Half-life • The time it takes for one half of the original amount of Half-life • The time it takes for one half of the original amount of](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-32.jpg)
Half-life • The time it takes for one half of the original amount of a drug in the body to be removed • A measure of the rate at which drugs are removed from the body Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Onset, Peak, and Duration Onset • The time it takes for the drug to Onset, Peak, and Duration Onset • The time it takes for the drug to](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-33.jpg)
Onset, Peak, and Duration Onset • The time it takes for the drug to elicit a therapeutic response Peak • The time it takes for a drug to reach its maximum therapeutic response Duration • The time a drug concentration is sufficient to elicit a therapeutic response Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![The Movement of Drugs Through the Body Drug actions • The cellular processes involved The Movement of Drugs Through the Body Drug actions • The cellular processes involved](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-34.jpg)
The Movement of Drugs Through the Body Drug actions • The cellular processes involved in the drug and cell interaction Drug effect • The physiologic reaction of the body to the drug Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Ways Drugs Produce Therapeutic Effects • Once the drug is at the site of Ways Drugs Produce Therapeutic Effects • Once the drug is at the site of](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-35.jpg)
Ways Drugs Produce Therapeutic Effects • Once the drug is at the site of action, it can modify the rate (increase or decrease) at which the cells or tissues function • A drug cannot make a cell or tissue perform a function it was not designed to perform Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacodynamics: Mechanisms of Action • Receptor interaction • Enzyme interaction • Nonspecific interactions See Pharmacodynamics: Mechanisms of Action • Receptor interaction • Enzyme interaction • Nonspecific interactions See](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-36.jpg)
Pharmacodynamics: Mechanisms of Action • Receptor interaction • Enzyme interaction • Nonspecific interactions See p. 27 Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Figure 2 -7 A, Drugs act by forming a chemical bond with specific receptor Figure 2 -7 A, Drugs act by forming a chemical bond with specific receptor](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-37.jpg)
Figure 2 -7 A, Drugs act by forming a chemical bond with specific receptor sites, similar to a key and lock. B, The better the “fit, ” the better the response. Those with complete attachment and response are called agonists. C, Drugs that attach but do not elicit a response are called antagonists. D, Drugs that attach, elicit a small response, and also block other responses are called partial agonists or agonist-antagonists. (From Clayton BD, Stock YN: Basic pharmacology for nurses, ed 13, St. Louis, 2004, Mosby. ) Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Pharmacotherapeutics: Types of Therapies • • Acute therapy Maintenance therapy Supplemental therapy Palliative therapy Pharmacotherapeutics: Types of Therapies • • Acute therapy Maintenance therapy Supplemental therapy Palliative therapy](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-38.jpg)
Pharmacotherapeutics: Types of Therapies • • Acute therapy Maintenance therapy Supplemental therapy Palliative therapy Supportive therapy Prophylactic therapy Empiric therapy Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring • The effectiveness of the drug therapy must be evaluated • One must Monitoring • The effectiveness of the drug therapy must be evaluated • One must](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-39.jpg)
Monitoring • The effectiveness of the drug therapy must be evaluated • One must be familiar with the drug’s: – Intended therapeutic action (beneficial) – Unintended but potential side effects (predictable, adverse reactions) Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) • • • Therapeutic index Drug concentration Patient’s condition Tolerance and dependence Monitoring (cont'd) • • • Therapeutic index Drug concentration Patient’s condition Tolerance and dependence](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-40.jpg)
Monitoring (cont'd) • • • Therapeutic index Drug concentration Patient’s condition Tolerance and dependence Interactions Side effects/adverse drug effects Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) • Therapeutic index – The ratio between a drug’s therapeutic benefits and Monitoring (cont'd) • Therapeutic index – The ratio between a drug’s therapeutic benefits and](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-41.jpg)
Monitoring (cont'd) • Therapeutic index – The ratio between a drug’s therapeutic benefits and its toxic effects Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) • Tolerance – A decreasing response to repetitive drug doses Mosby items Monitoring (cont'd) • Tolerance – A decreasing response to repetitive drug doses Mosby items](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-42.jpg)
Monitoring (cont'd) • Tolerance – A decreasing response to repetitive drug doses Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) • Dependence – A physiologic or psychological need for a drug Mosby Monitoring (cont'd) • Dependence – A physiologic or psychological need for a drug Mosby](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-43.jpg)
Monitoring (cont'd) • Dependence – A physiologic or psychological need for a drug Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) Interactions may occur with other drugs or food • Drug interactions: the Monitoring (cont'd) Interactions may occur with other drugs or food • Drug interactions: the](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-44.jpg)
Monitoring (cont'd) Interactions may occur with other drugs or food • Drug interactions: the alteration of action of a drug by: – Other prescribed drugs – Over-the-counter medications – Herbal therapies Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) • Drug interactions – Additive effect – Synergistic effect – Antagonistic effect Monitoring (cont'd) • Drug interactions – Additive effect – Synergistic effect – Antagonistic effect](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-45.jpg)
Monitoring (cont'd) • Drug interactions – Additive effect – Synergistic effect – Antagonistic effect – Incompatibility Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) • Medication misadventures – Adverse drug events – Adverse drug reactions – Monitoring (cont'd) • Medication misadventures – Adverse drug events – Adverse drug reactions –](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-46.jpg)
Monitoring (cont'd) • Medication misadventures – Adverse drug events – Adverse drug reactions – Medication errors Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Monitoring (cont'd) Some adverse drug reactions are classified as side effects • Expected, well-known Monitoring (cont'd) Some adverse drug reactions are classified as side effects • Expected, well-known](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-47.jpg)
Monitoring (cont'd) Some adverse drug reactions are classified as side effects • Expected, well-known reactions that result in little or no change in patient management • Predictable frequency • The effect’s intensity and occurrence are related to the size of the dose Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Adverse Drug Reaction An adverse outcome of drug therapy in which a patient is Adverse Drug Reaction An adverse outcome of drug therapy in which a patient is](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-48.jpg)
Adverse Drug Reaction An adverse outcome of drug therapy in which a patient is harmed in some way • • Pharmacologic reactions Idiosyncratic reactions Hypersensitivity reactions Drug interactions Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Iatrogenic Responses Unintentional adverse effects that are treatment induced • • Dermatologic Renal damage Iatrogenic Responses Unintentional adverse effects that are treatment induced • • Dermatologic Renal damage](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-49.jpg)
Iatrogenic Responses Unintentional adverse effects that are treatment induced • • Dermatologic Renal damage Blood dyscrasias Hepatic toxicity Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Other Drug-Related Effects • Teratogenic • Mutagenic • Carcinogenic Mosby items and derived items Other Drug-Related Effects • Teratogenic • Mutagenic • Carcinogenic Mosby items and derived items](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-50.jpg)
Other Drug-Related Effects • Teratogenic • Mutagenic • Carcinogenic Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Toxicology The study of poisons and unwanted responses to therapeutic agents Mosby items and Toxicology The study of poisons and unwanted responses to therapeutic agents Mosby items and](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-51.jpg)
Toxicology The study of poisons and unwanted responses to therapeutic agents Mosby items and derived items © 2005, 2002 by Mosby, Inc.
![Table 2 -9 Common Poisons and Antidotes Mosby items and derived items © 2005, Table 2 -9 Common Poisons and Antidotes Mosby items and derived items © 2005,](http://slidetodoc.com/presentation_image/94785804c8c0e32b2ffd17b61ff4a165/image-52.jpg)
Table 2 -9 Common Poisons and Antidotes Mosby items and derived items © 2005, 2002 by Mosby, Inc.
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