Chapter 16 The Molecular Basis of Inheritance Question
Chapter 16 The Molecular Basis of Inheritance
Question? u. Traits are inherited on chromosomes, but what in the chromosomes is the genetic material?
Qualifications
For testing: u. Name(s) of experimenters u. Outline of the experiment u. Result of the experiment and the importance of the result
Griffith - 1928
Griffith’s Experiment
Result
Problem
Avery, Mc. Carty and Mac. Leod - 1944
Hershey- Chase 1952
Bacteria with Phages
Phage Components
Used Tracers
Experiment
Result DNA is the genetic material.
Picture Proof
Chargaff - 1947
Chargaff’s Rule
Why?
Watson and Crick 1953
Rosalind Franklin
Book
DNA Composition
DNA Backbone
Nitrogen Bases
Chargaff’s Rule
Watson and Crick
Replication
Models for DNA Replication
Replication Models
Meselson - Stahl late 1950’s
Results
Replication - Preview
Origins of Replication
Prokaryotic
Eukaryotic Cells
DNA Elongation
Energy for Replication
Problem of Antiparallel DNA
Leading Strand
Lagging Strand
Priming
Priming
Okazaki Fragments
Enzymes
Other Proteins in Replication
Enzyme Summary
DNA Replication Error Rate
Reasons for Accuracy
DNA Repair
Example:
Xeroderma Pigmentosum Cancer Protected from UV
Thymine Dimers
Excision Repair
Problem - ends of DNA
Result
Telomeres
Telomeres
Telomeres
Implication
Telomerase
Comment
Summary u. Know the Scientists and their experiments. u. Why DNA is an excellent genetic material. u. How DNA replicates. u. Problems in replication.
- Slides: 82
