CHAPTER 10 CANCER CHAPTER ANZDATA Registry Characteristic Table

CHAPTER 10 CANCER CHAPTER © ANZDATA Registry

Characteristic Table 1: Characteristics of people with and without myeloma treated by dialysis between 1963 -2009 Total (%) Country of residence Australia New Zealand Primary renal disease Myeloma Potentially Myeloma related Glomerulonephritis/Ig. A nephropathy Diabetes Other Age at ESKD <55 55 -64 65 -74 75+ Sex Female Male Era of ESKD <1990 -1994 1995 -1999 2000 -2004 2005 -2009 First Dialysis modality Haemodialysis Peritoneal dialysis Racial background Non-white White Other malignancy prior to ESKD None Pre-dialysis malignancy Other malignancy subsequent to ESKD None Post-dialysis malignancy Smoking history at ESKD Never or unknown Current or former Diabetes Mellitus No Yes Unknown * Status during follow-up Alive Died Myeloma n % 807 1 Non-Myeloma n % 53, 371 99 690 117 86 15 44, 256 9, 115 83 17 636 47 35 24 65 79 6 4 3 8 0 608 15, 906 12, 728 24, 129 0 1 30 24 45 124 225 298 160 15 28 37 20 24, 784 11, 862 10, 993 5, 732 46 22 21 11 300 507 37 63 22, 482 30, 889 42 58 80 70 97 256 304 10 9 12 32 26 12, 956 6, 491 9, 051 11, 211 13, 662 24 12 17 21 26 668 139 83 17 36, 539 16, 832 68 32 47 760 6 94 11, 792 41, 579 22 78 743 64 92 8 49, 682 3, 689 93 7 786 21 97 3 48, 766 4, 605 91 9 344 463 43 57 31, 667 21, 704 59 41 589 131 87 73 16 11 36, 828 8, 188 8, 355 69 15 16 117 690 15 86 21, 149 32, 222 40 60 © ANZDATA Registry

Figure 1: Plot of myeloma diagnosis relative to timing of ESKD and dialysis commencement © ANZDATA Registry

Figure 2 a: Unadjusted survival on dialysis for myeloma versus non myeloma patients © ANZDATA Registry

Figure 2 b Unadjusted survival on dialysis, stratified by primary renal disease © ANZDATA Registry

Table 2: Average of people starting dialysis through time Myeloma Non-myeloma Era of dialysis N Median (IQR) N Median age (IQR) <1990 80 61. 5 (55. 2 - 66. 1) 12, 956 47. 0 (33. 7 - 57) 1990 -1994 70 64. 6 (56. 7 - 70. 1) 6, 491 55. 4 (41. 4 - 65. 2) 1995 -1999 97 65. 8 (57. 9 - 72. 2) 9, 051 58. 6 (45. 2 - 68. 7) 2000 -2004 256 68. 4 (59. 4 - 74. 9) 11, 211 61. 4 (48. 6 - 71. 7) 2005 -2009 304 68. 9 (61. 7 - 74. 6) 13, 662 62. 5 (50. 4 - 72. 9) © ANZDATA Registry

Table 3: Cause of death for people on dialysis with and without myeloma in Australia and New Zealand 1963 -2009 * Myeloma Non myeloma Total deaths 609 Total deaths 32, 223 N (%) 102 (14. 8) 12, 842 (39. 9) Vascular 23 (3. 3) 3, 478 (10. 8) Infection 70 (10. 1) 4, 785 (14. 9) Cancer 383 (55. 5) 2, 739 (8. 5) Social 99 (14. 4) 5, 934 (18. 4) Other 13 (1. 9) 2, 445 (7. 6) Cause of death Cardiovascular © ANZDATA Registry

Figure 3: Unadjusted survival on dialysis for people with (MM) and without myeloma (non. MM), by age at starting dialysis and stratified by era of treatment * © ANZDATA Registry

Table 4: Risk of death for people with myeloma treated with dialysis in Australia and New Zealand 1963 -2009 Characteristic Primary renal disease Myeloma (referent) Univariate Hazard ratio (95% CI) P for difference 1. 0 0. 0002 Multivariate Hazard ratio (95% CI) P for difference 1. 0 0. 0004 Potentially Myeloma related Glomerulonephritis/Ig. A nephropathy Diabetes Other 0. 7 (0. 5 -0. 9) 0. 6 (0. 5 -0. 9) 0. 7 (0. 5 -1. 0) 0. 7 (0. 5 -1. 1) 0. 6 (0. 5 -0. 8) 0. 7 (0. 5 -0. 8) 0. 6 (0. 4 -0. 8) <55(referent) 55 -64 65 -74 75+ 1. 0 0. 8 (0. 7 -1. 1) 1. 4 (1. 1 -1. 7) 1. 3 (1. 0 -1. 7) <0. 0001 Female (referent) Male Era of dialysis <1990 (referent) 1990 -1994 1995 -1999 2000 -2004 2005 -2009 Timing of myeloma diagnosis relative to ESKD > 5 years before ESKD (referent) 1. 0 (0. 9 -1. 2) 0. 73 1. 0 1. 1 (0. 8 -1. 5) 0. 8 (0. 6 -1. 1) 1. 0 (0. 8 -1. 3) 1. 0 (0. 7 -1. 2) 0. 51 1. 0 0. 15 1 -5 years before ESKD 1. 1 (0. 8 -1. 4) 1 -11 months before ESKD Peri ESKD (within 1 month before or after ESKD) 1 -12 months after ESKD First Dialysis modality Haemodialysis (referent) Peritoneal dialysis Racial background Non-white (referent) White Other malignancy prior to ESKD None (referent) Pre-dialysis malignancy Smoking history at ESKD Never (referent) Current or former Diabetes at ESKD No diabetes (referent) Diabetes 1. 3 (1. 0 -1. 7) Age 1. 0 0. 9 (0. 7 -1. 2) 1. 6 (1. 3 -2. 1) 1. 7 (1. 3 -2. 3) <0. 0001 1. 0 0. 7 (0. 6 -0. 9) 0. 006 1. 0 1. 5 (1. 2 -1. 8) <0. 001 Sex 1. 3 (1. 0 -1. 7) 1. 1 (0. 8 -1. 6) 1. 0 0. 8 (0. 7 -1. 0) 0. 06 1. 0 0. 9 (0. 7 -1. 3) 0. 59 1. 0 0. 9 (0. 7 -1. 2) 0. 52 1. 0 0. 9 (0. 9 -1. 2) 0. 94 1. 0 1. 4 (1. 1 -1. 7) 0. 002 © ANZDATA Registry