Chapter 1 Introduction to Respiratory Care Pharmacology Chapter

Chapter 1 – Introduction to Respiratory Care Pharmacology Chapter 2 – Principles of Drug Action RES 219 Pharmacology

Naming of Drugs l l l Chemical name Code name Generic name Official name Trade/Brand name

Sources of Drug Information Physician’s Desk Reference (PDR) l l l l Drug name Clinical pharmacology Indications Contraindications Drug interactions l Additive l Synergism l Potentiation Drug reactions Drug dosage Route of administration

5 Categories for Routes of Administration l l l Enteral l Oral l Sublingual l Nasogastric l Rectal Parenteral l Intravenous l Intramuscular l Subcutaneous l Central lines Transdermal Topical Inhalation

Pharmacokinetics l Absorption l l Distribution l l l Protein binding Fat solubility Metabolism l l Bioavailability Lipid diffusion Blood flow First-pass effect Elimination l l Clearance Plasma half-life

Protein Binding

Low Protein

Protein Displacement

First-Pass Effect

Time-Effect Curve

Pharmacokinetics of Inhaled Aerosol Drugs l l Local vs systemic effect Inhaled aerosols in treating pulmonary disease Distribution of inhaled aerosols L/T Ratio

L/T Ratio

Pharmacodynamics l l l Drug receptors Selectivity Agonist vs. Antagonist Potency Dose-Response Curves l l l Potency & Efficacy Tolerance Dependence

Dose-Response Curve

The Prescription

Abbreviations l l Page 8 Table 1 -3

http: //www. youtube. com/wa tch? v=8 z. YIEi. Xv. SZY http: //www. youtube. com/wa tch? v=xiu. Wd. JYy. IKs&featur e=related

http: //www. youtube. com/wa tch? v=4 G 6 Rem 38 aks&feat ure=related http: //www. youtube. com/wa tch? v=2 uehdq. Zz. KEM&feat ure=related