Chapter 1 Chromosome 1 DNA Sequence Chromosome 1

Chapter 1: Chromosome 1 DNA Sequence Chromosome 1 Name of Gene GLC 1 A Name of Protein 1228 bp myocili n transcription m. RNA Amino acid sequence 490 aa translation What does this protein make up or do? may cause increased pressure in the eye by obstructing the aqueous outflow Condition/Disease Glaucoma

Description of Glaucoma n Symptoms and characteristics n Glaucoma is an eye disease in which the fluid pressure inside the eyes slowly rises, leading to loss of vision and/or blindness. n At first, there are no symptoms n If glaucoma remains untreated, people may miss objects to the side and out of the corner of their eye, progressing to tunnel vision and blindness. n Glaucoma is detected through a comprehensive eye exam. Normal Vision As viewed by a person with Pictures used with permission from glaucoma URL: http: //www. nei. nih. gov/health/glauco ma/glaucoma_facts. asp

Description of Glaucoma (cont. ) n Who is affected? Anyone, but the following have a higher risk: n n Outlook or quality of life n n n African Americans over the age of 40 Everyone over the age of 60, especially Mexican Americans People with a family history of glaucoma With early treatment, eyes may be protected from serious vision loss Without treatment, individuals develop tunnel vision (only straight -ahead vision) and, over time, no vision (blindness). Treatments include medicine, laser procedure and/or surgery. There is no cure for glaucoma; Vision that is lost cannot be restored. Researcher: Jane Sample

References n NCBI. Genes and Disease: Glaucoma [online]. 2003. [cited 2004 July 14]. Available at URL: http: //www. ncbi. nlm. nih. gov/books/bv. fcgi? call=bv. View. . Show. Section&rid=gnd. section. 127. n NCBI. Entrez [online]. 2003. [cited 2004 July 14]. Available at URL: http: //www. ncbi. nih. gov/Entrez/. n National Eye Institute. Glaucoma: What you should know [online]. 2004. [cited July 14]. Available at URL: http: //www. nei. nih. gov/health/glaucoma_facts. asp.