Chapt Mutations Mutagenesis and DNA repair mutant mutation

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Chapt. Mutations, Mutagenesis and DNA repair • mutant ; 돌연변이체 • mutation ; 돌연변이

Chapt. Mutations, Mutagenesis and DNA repair • mutant ; 돌연변이체 • mutation ; 돌연변이 (DNA 염기 순서의 변화) • mutagen ; 돌연변이원 (물리적 매개물, 화학적 물질) • mutagenesis ; 돌연변이 발생 BIOPARK

2) Chemical mutagen ; BIOPARK

2) Chemical mutagen ; BIOPARK

3) UV BIOPARK

3) UV BIOPARK

4) Intercalating Agents ; BIOPARK

4) Intercalating Agents ; BIOPARK

1. Action of DNA glycosylases. (Base excision repair)

1. Action of DNA glycosylases. (Base excision repair)

2. DNA Repair(nucleotide excision repair) BIOPARK

2. DNA Repair(nucleotide excision repair) BIOPARK

The mechanism of nucleotide excision repair(NER) of pyrimidine dimers.

The mechanism of nucleotide excision repair(NER) of pyrimidine dimers.

⊙ E. coli UV (자외선) DNA damage (thymine dimer) Endonuclease ( DNA의 phosphodiester 결합절단

⊙ E. coli UV (자외선) DNA damage (thymine dimer) Endonuclease ( DNA의 phosphodiester 결합절단 DNA polymerase I DNA 구조변화 3’ – on 말단 연장 ) DNA 복제 방해 (돌연변이) if) Endonuclease(Uvr. ABC) 활성결여 → Xeroderma Pigmentosum BIOPARK

3. The mechanism of mismatch repair in E. coli.

3. The mechanism of mismatch repair in E. coli.

4. X-ray structure of human Ku protein in complex with a 14 -bp DNA.

4. X-ray structure of human Ku protein in complex with a 14 -bp DNA. (double-strand break)

Crossing-over.

Crossing-over.

Rec. A Ruv. C Ruv. AB The Holliday model of general recombination between homologous

Rec. A Ruv. C Ruv. AB The Holliday model of general recombination between homologous DNA duplexes.

X-Ray structure of a Holliday junction.

X-Ray structure of a Holliday junction.

X-Ray structure of a Holliday junction.

X-Ray structure of a Holliday junction.

Model of a Rec. A-DNA complex.

Model of a Rec. A-DNA complex.

A model for Rec. A-medated pairing.

A model for Rec. A-medated pairing.

Model for Rec. A-medated strand exchange.

Model for Rec. A-medated strand exchange.

GCTGGTGG The generation of a 3’-ending single-strand DNA segment by Rec. BCD to initiate

GCTGGTGG The generation of a 3’-ending single-strand DNA segment by Rec. BCD to initiate recombination.

X-Ray structure of a Ruv. A-Holliday junction complex.

X-Ray structure of a Ruv. A-Holliday junction complex.

Ruv. AB-Holliday junction complex.

Ruv. AB-Holliday junction complex.

5’ 3’ The recombination repair of a replication fork that has encountered a single-strand

5’ 3’ The recombination repair of a replication fork that has encountered a single-strand nick.

The repair of a double-strand break in DNA by homologous end-joining.

The repair of a double-strand break in DNA by homologous end-joining.

Transposition Structure of IS(insertion sequence) elements.

Transposition Structure of IS(insertion sequence) elements.

A model for transposon insertion.

A model for transposon insertion.

A map of transposon Tn 3.

A map of transposon Tn 3.

A composite transposon.

A composite transposon.

A model for transposition involving the intermediacy of a cointegrate.

A model for transposition involving the intermediacy of a cointegrate.

Chromosomal rearrangement via recombination.

Chromosomal rearrangement via recombination.

Instability Mutation and DNA repair Mutations DNA repairInstability Mutation and DNA repair Mutations DNA repair
Instability Mutation and DNA repair Mutations DNA repairInstability Mutation and DNA repair Mutations DNA repair
MUTATION SPONTANEOUS MUTATIONS INDUCED MUTATIONS MUTATIONS Mutations areMUTATION SPONTANEOUS MUTATIONS INDUCED MUTATIONS MUTATIONS Mutations are
Chapt 11 12 Chapt 11 Growth Expansion ChaptChapt 11 12 Chapt 11 Growth Expansion Chapt
Mutations Mutations Hollywoods images of mutation Mutations ActualMutations Mutations Hollywoods images of mutation Mutations Actual
Mutations Hollywoods images of mutation Mutations Actual MutationsMutations Hollywoods images of mutation Mutations Actual Mutations
Mutation and Mutagenesis Mutation is a sudden heritableMutation and Mutagenesis Mutation is a sudden heritable
Mutations Mutations overview Smallscale mutations Missense mutations NonsenseMutations Mutations overview Smallscale mutations Missense mutations Nonsense
Mutations Mutations Types of Mutations Point Mutations occursMutations Mutations Types of Mutations Point Mutations occurs
Sitespecific mutagenesis DNA PCR Sitespecific mutagenesis Horton 1997Sitespecific mutagenesis DNA PCR Sitespecific mutagenesis Horton 1997
DNA damage repair and recombination MUTAGENESIS DNA DAMAGEDNA damage repair and recombination MUTAGENESIS DNA DAMAGE
DNA damage repair and recombination MUTAGENESIS DNA DAMAGEDNA damage repair and recombination MUTAGENESIS DNA DAMAGE
DNA damage repair and recombination MUTAGENESIS DNA DAMAGEDNA damage repair and recombination MUTAGENESIS DNA DAMAGE
Chapter 7 a DNA mutation and repair MutationChapter 7 a DNA mutation and repair Mutation
Mutation and DNA repair A mutation is aMutation and DNA repair A mutation is a
Chapter 7 a DNA mutation and repair MutationChapter 7 a DNA mutation and repair Mutation
DNA MUTATIONS Mutation Mutation Any change in aDNA MUTATIONS Mutation Mutation Any change in a
Chapter 16 Mutations and DNA Repair A mutationChapter 16 Mutations and DNA Repair A mutation
DNA Repair Repair and Recombination Mutation frequencies 235DNA Repair Repair and Recombination Mutation frequencies 235
DNA Repair Repair and Recombination Mutation frequencies 235DNA Repair Repair and Recombination Mutation frequencies 235
DNA Mutations Technology What are genetic mutations MutationDNA Mutations Technology What are genetic mutations Mutation
What makes a mutant Mutations Mutation is aWhat makes a mutant Mutations Mutation is a
Mutations in DNA Mutations Mutations changes in theMutations in DNA Mutations Mutations changes in the
MUTATIONS Mutations Changes to DNA are called mutationsMUTATIONS Mutations Changes to DNA are called mutations