Changes of Presenile Cataracts that had been Operated

Changes of Presenile Cataracts that had been Operated over 10 years in Korea Sung Kun Chung, M. D. ; Eun-Jung Jun, M. D. Hyun Seung Kim. Department of Ophthalmology and Visual Science, The Catholic University of Korea No author has any financial or proprietary interest in any materials or methods mentioned

Introduction Many studies about senile cataract : aged more than 60 years old : age is one of the most important risk factors of cataract n n Presenile cataract patients may display different characteristics from senile cataract patients Purpose n To investigate the long-term characteristics and changes of presenile cataracts that had been operated in Korea.

Materials & Methods Inclusion criteria ① aged from 30 to 50 years ② underwent cataract surgeries at St. Mary’s hospital from 1995 to 2004(n=976) n Exclusion criteria ① patients with histories of ocular trauma or uveitis ② those received combined surgeries n Retrospective review of medical records n Analyze ① age & sex : 31 -40, 41 -50 group ② their histories of diabetes and hypertension ③ types of lens opacities ④ preoperative and postoperative visual acuities n • Lens opacity grading : LOCSⅢ (Lens Opacity Classification System III) • Statistical analysis : Cochran-Armitage proportion trend test

Results 30 -39 years 40 -49 years Total Mean age 36. 2 45. 3 41. 7 Male 299(38. 8%) 472(61. 2%) 771(79. 0%) Female 81(39. 5%) 124(60. 5%) 205(21. 0%) History of diabetes 20(20. 0) 78(80. 0) 98(10. 0%) History of hypertension 16(21. 1%) 60(78. 9%) 76(7. 8%)

Results

Results Lens opacities in each age group (LOCSⅢ) Anterior polar Opacity Posterior subcapsular opacity (PSCO) Anterior polar opacity +PSCO Cortical opacity Nuclear opacity 30 -39 years n (%) 147 (42. 2%) 104 (30. 3%) 34 (50%) 12 (20. 3%) 16 (30. 2%) 40 -49 years n (%) 201 (57. 8%) 239 (69. 7%) 34 (50%) 47 (79. 7%) 37 (69. 8%) Total n (%) 348 (35. 7%) 343 (35. 1%) 68 (7. 0%) 59 (6. 0%) 53 (5. 4%)

Results Region of study Sample size, race Methods of evaluation Age Prevalence(%) Group Cortical Nuclear (yrs) PSC Male Beijing, China Shih. Pai, Tai wan Singapo re 4439, Chinese 1361, Chinese slit-lamp c AREDS Slit-lamp c LOCSⅢ ≥ 40 0. 3 82. 2 4. 3 ≥ 65 21. 9 38. 9 9. 2 No statistically significant difference in gender Female predominance 1717, Chinese 919, Slit-lamp c LOCSⅢ 40 -79 23. 9 22. 6 7. 0 ≥ 21 4 5. 7 No statistically significant difference in gender Female predominance except cortical cat. Slit-lamp c WCGS Slit-lamp c LOCSⅢ ≥ 40 11. 3 12. 6 4. 08 5. 4 35. 1 Female predominance Male predominance Sumatra, Indonesian Victoria, Australia 4433, Korea 976, Korean Australian 30 -49 6. 0 *PSC : posterior subcapsular *c : with *AREDS : Age-related Eye disease Study *LOCSⅢ : Lens Opacities Classification System Ⅲ *cat. : cataract *JCCESG : Japanese Cooperative Cataract Epidemiology Study Group *WCGS : Wilmer cataract grading scheme Prevalence(%) Female

Results n Eyes that had surgeries for presenile cataracts displayed statistically significant decrease(p = 0. 0002, CI 95%) n Presenile cataracts with diabetes showed no significant trend with the passage of time(p = 0. 4767, CI 95%) n Presenile cataracts with hypertension showed statistically significant increase (p = 0. 0049, CI 95%)

Conclusion n Presenile cataract patients had different characteristics from senile cataract patients. n Men consisted of the majority of the presenile cataract patients. n Anterior polar opacity was the most common type of lens opacity. n Cataracts with hypertension showed overall increase over 10 years.