Cellular Pathology R Virchow Berlin 1858 cellular pathology

Cellular Pathology R. Virchow, Berlin 1858 cellular pathology (h 1) K. von Rokitansky, Vienna macroscopic pathology Cytometry T. Caspersson G. Wied Prague, Munich Berlin, Chicago 1946 TICAS image analysis 1968 (h 5/6) L. Koss Vienna, NY 1952 histo-/cytopathology (h 7/8) Stockholm 1934 - cytometry by light absorption - chromosome banding (h 2) Flow Cytometry W. Coulter Hialeah, 1949/56 electronic blood cell counter (h 3/h 4) Early developments In flow and image cytometry flow cytometry G. Ruhenstroth-Bauer, D. Zang Munich 1960 M. Melamed NY 1960 cyto-/histopathology (h 10) artifactual right skew of Coulter cell volume distribution curves (h 13/17) flow cytometry Z. Darzynkiewicz Warsaw, NY 1963 cell biology by flow cytometry (h 11) L. Kamentsky NY 1965 - first flow cytometer by light absorption (h 9) - computerized data evaluation&display - European background - US background - innovations B. Mayall LLL 1965 -CYDAC chromosome DNA analysis -editor Cytometry (h 12) M. Fulwyler Los Alamos 1965 cell sorter (h 16) M. van Dilla W. Göhde Los Alamos 1968 Münster 1968 first fluorescence by - first fluorescence flow cytometry (h 19) flow cytometer Phywe-ICP 11 fluorescent DNA L. Herzenberg as tumor marker Stanford 1969 (EB) (h 20 -22) first fluorescence activated cell sorter (FACS) (h 23) CC Lushbaugh Los Alamos 1962 biological right skew claim (h 14/15) R. Thom, V. Kachel Munich 1969 hydrodynamic focusing in electrical sizing eliminates artefactual right skew (h 18) G. Valet Munich/Martinsried 1972 - cytometry bioinformatics 72/87 ) - predictive medicine by cytomics 1997/2001 (h 24 -26) - cell function in disease

Foundation of Society for Analytical Cytology American Engineering Foundation conferences organizer: Sandford S. Cole (h 27) European conferences (initial preference for image cytometry) motivator: W. Göhde (mainly flow) Bio. Physics/Ortho/Coulter/BD laser cytometers Phywe ICP-11/22 mercury arc cytometer 1970 Davos (K. Preston) 1972 Heidelberg (M. Andreeff) 1971 Henniker, NH (K. Preston) 1973 Nijmegen (C. Haanen) 1972 Saxtons River, VE (K. Preston) 1975 Münster (W. Göhde) 1973 Asilomar, CA (M. Mendelsohn) 1977 Vienna (D. Lutz) 1975 Asilomar, CA (L. Wheeless) 1979 Voss (O. Laerum) 1976 Pensacola, FL (P. Mullaney) 1980 Rome (F. Mauro) 1978 Schloß Elmau/Mittenwald (T. Jovin) foundation of the Society for Analytical Cytology (SAC) & journal Cytometry at Schloß Elmau 1978 conference renamed: 1991: International Society for Analytical Cytology (ISAC) 2010: International Society for Advancement of Cytometry (ISAC)