Cell Division Mitosis Cell Division Produce offspring asexually

Cell Division Mitosis

Cell Division • Produce offspring (asexually) • Repair and growth

Cell Cycle Ch. 9

Chromosomes • Piece of DNA • Wrapped around accessory proteins

Mitosis

IPMAT http: //bilingualbiology 11 a. blogspot. com/2010/12/cell-cycle-mitosis-and-meiosis. html

Prophase • Chromatin coils into chromosomes • Mitotic spindle begins to form • Late in prophase, nuclear membrane dissolves, spindle microtubules grab chromosomes

Metaphase • Mitotic spindle fully formed • Chromosomes lined up along cell’s “equator”

Anaphase • Sister chromatids separate • Microtubules holding chromatids shorten, pulling them to ends of cell • Microtubules not holding chromatids lengthen, elongating the cell

Telophase • • Opposite of prophase Nuclear envelopes reform Chromosomes uncoil Mitotic spindle dissolves • Cytokinesis generally happens with telophase

Cytokinesis • Separating everything else

Mitosis

Am I a Plant or Animal?

Cell Cycle regulation • Growth factors • CDK & cyclins • Density-dependent inhibition • Anchorage dependence

Cancer • Transformation • Tumor: benign or malignant • Metastasis

Concept Check 1. Describe a significant event that occurs in each of the four stages of mitosis. 2. Compare and contrast cytokinesis in animal and plant cells. 3. In what sense may prophase and telophase in mitosis be characterized as opposites? 4. Identify 3 factors that regulate cell division and explain how a dysfunction/mutation in each leads to cancer.