Cell adaptation injury and death Inflammation and Repair

เนอหา • Cell adaptation, injury and death • Inflammation and Repair • Hemodynamic disorder

Cell adaptation, injury and death

Cell adaptation, injury and death Reversible cell injury; • Cloudy swelling of Hepatocytes (Micros) • Fatty change of Liver (Gross&Micros) • Hyaline change; Mallory bodies in hepatocytes (Micros)

Cloudy swelling of Hepatocytes (Micros)

Fatty change of Liver (Gross&Micros)

Fatty change of Liver (Gross&Micros)

Hyaline change; Mallory bodies in hepatocytes (Micros)

Cell adaptation, injury and death Irreversible injury; • • • Coagulative necrosis of Kidney (Renal infarct) Coagulative necrosis of Spleen (Splenic infarct) Liquefactive necrosis of Lung (Lung abscess) Liquefactive necrosis of Brain (Brain infarct) Caseous necrosis of Lymph nodes Enzymatic fat necrosis in Acute pancreatitis

Coagulative necrosis of Kidney (Gross&Micros)

Coagulative necrosis of Kidney (Gross)

Coagulative necrosis; Renal infarct

Coagulative necrosis; Splenic infarct

Liquefactive necrosis; Lung abscess

Liquefactive necrosis; Brain infarct

Liquefactive necrosis; Brain infarct

Caseous necrosis of Lymph nodes (Gross & Micro)

Caseous necrosis; TB lymph nodes

Enzymatic fat necrosis in Acute pancreatitis (Gross&Micros)

Cell adaptation, injury and death Cellular adaptation; • Hypertrophy ( Heart and Uterus) • Testicular atrophy • Prostatic hyperplasia Cellular accumulation; • Cholesterolosis of Gall bladder

Testicular atrophy (Gross)

Ventricular Hypertrophy (Gross&Micros)

Hypertrophy; Pregnant uterus

Prostatic hyperplasia (Gross&Micros)

Cholesterolosis of Gall bladder (Gross&Micros)

Inflammation and Repair Inflammatory cells; • • Neutrophils Macrophages Lymphocytes Plasma cells

Neutrophils

Macrophages

Lymphocytes

Plasma cells

Inflammation and Repair Acute inflammation; • Acute appendicitis (Gross ) • Acute cholecystitis (Gross ) • Breast abscess (Gross )

Acute appendicitis (Gross )

Acute cholecystitis (Gross )

Breast abscess (Gross )

Inflammation and Repair Chronic cholecystitis ( Micros) Granulation tissue ( Micros) Granulomatous inflammation ( Micros) Keloid (Gross&Micros) Scar contracture (Gross )

Chronic cholecystitis ( Micros)

Granulation tissue ( Micros)

Granulomatous inflammation ( Micros)

Keloid (Gross&Micros)

Hemodynamic disorders

Pitting edema

Pulmonary edema

Pulmonary edema

Hemorrhage • Petechiae 1 -2 mm • Purpura > 3 mm • Ecchymoses 1 -2 cm • Hematoma

Petechial hemorrhage

Hematoma in Cerebral cortex

Shock • Acute respiratory distress syndrome (Shock lung) - ARDS • Centrilobular hemorrhagic necrosis of liver (Shock liver)

ARDS – Shock lung

ARDS – Shock lung Hyaline membrane

Shock liver – Nutmeg liver

Shock liver – Nutmeg liver

Thrombosis and Embolism • Thrombosis in Hemorrhoid • Thrombotic embolism • Tumor embolism • Amniotic embolism • Fat embolism

Thrombosis in Hemorrhoid

Thrombosis in Hemorrhoid

Thrombotic embolism in aorta

Tumor embolism

Amniotic embolism Fetal squame cells in pulmonary vessel

Fat embolism Bone marrow in vessel

Infarction • Renal infarct • Myocardial infarct • Hemorrhagic necrosis of small bowel – Gangrene bowel • Gangrene of toe

Renal infarct

Renal infarct

Myocardial infarct

Gangrene bowel

Gangrene; Small intestine

Gangrene; Small intestine

Wet gangrene of toes

Dry gangrene of fingers

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