CD 244 maintains the proliferation ability of leukemia

CD 244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p 27 kip 1 signaling by Feifei Zhang, Xiaoye Liu, Chiqi Chen, Jun Zhu, Zhuo Yu, Jingjing Xie, Li Xie, Haitao Bai, Yaping Zhang, Xia Fang, Hao Gu, Chun Wang, Wei Weng, Cheng Zhang, Guo-Qiang Chen, Aibing Liang, and Junke Zheng haematol Volume 102(4): 707 -718 March 31, 2017 © 2017 by Ferrata Storti Foundation

CD 244 is required for the proliferation of both human leukemia cell lines and acute myeloid leukemia initiating cells (LICs). Feifei Zhang et al. Haematologica 2017; 102: 707 -718 © 2017 by Ferrata Storti Foundation

CD 244 promotes leukemogenesis in a murine acute myeloid leukemia (AML) model. Feifei Zhang et al. Haematologica 2017; 102: 707 -718 © 2017 by Ferrata Storti Foundation

CD 244 regulates the proliferation ability of leukemia initiating cells (LICs). Feifei Zhang et al. Haematologica 2017; 102: 707 -718 © 2017 by Ferrata Storti Foundation

CD 244 manipulates p 27 levels to maintain the proliferation ability of leukemia-initiating cells (LICs). Feifei Zhang et al. Haematologica 2017; 102: 707 -718 © 2017 by Ferrata Storti Foundation

CD 244 regulates the p 27 stability through SHP-2 signaling. Feifei Zhang et al. Haematologica 2017; 102: 707 -718 © 2017 by Ferrata Storti Foundation

CD 244 interacts with c-Kit to maintain the stability of p 27. Feifei Zhang et al. Haematologica 2017; 102: 707 -718 © 2017 by Ferrata Storti Foundation

CD 244 controls the activities of human leukemia cells through SHP-2/p 27 signaling. Feifei Zhang et al. Haematologica 2017; 102: 707 -718 © 2017 by Ferrata Storti Foundation