CARDIOVASCULAR SYSTEM TRANSPORT O 2 CO 2 NUTRIENTS

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CARDIOVASCULAR SYSTEM TRANSPORT

CARDIOVASCULAR SYSTEM TRANSPORT

 • • O 2 CO 2 NUTRIENTS WASTE PRODUCTS & TOXINS HORMONES EXCESS

• • O 2 CO 2 NUTRIENTS WASTE PRODUCTS & TOXINS HORMONES EXCESS HEAT PROTECTIVE CELLS/ SUBSTANCES

HEART – 2 PUMPS Body Lungs RV LV Lungs

HEART – 2 PUMPS Body Lungs RV LV Lungs

EVENTS: RA Diastole RV RA Systole RV LA LV

EVENTS: RA Diastole RV RA Systole RV LA LV

INNERVATION OF HEART: PARASYMPATHETIC NERVE SUPPLY Right Vagus SA node Left Vagus RA AV

INNERVATION OF HEART: PARASYMPATHETIC NERVE SUPPLY Right Vagus SA node Left Vagus RA AV node LA RV LV

Parasympathetic fibers: • • Dorsal motor nucleus of vagus Nucleus tractus solitarius Nucleus ambiguus

Parasympathetic fibers: • • Dorsal motor nucleus of vagus Nucleus tractus solitarius Nucleus ambiguus Right vagus: Right atrium Sino-Atrial (S. A) node • Left vagus: Left atrium Atrio-Ventricular(A. V) node Bundle of HIS

VAGAL STIMULATION: • Chronotropic effect – Heart rate • Dromotropic effect – Rate of

VAGAL STIMULATION: • Chronotropic effect – Heart rate • Dromotropic effect – Rate of conduction • Bathmotropic effect – Excitability of heart • Inotropic effect – Myocardial contractility

SYMPATHETIC NERVE SUPPLY Superior Middle Inferior RA LA T 1 T 2 T 3

SYMPATHETIC NERVE SUPPLY Superior Middle Inferior RA LA T 1 T 2 T 3 T 4 T 5 RV LV

Sympathetic fibers: • Upper thoracic segments (T 1 -T 5) • Right sympathetic fibers:

Sympathetic fibers: • Upper thoracic segments (T 1 -T 5) • Right sympathetic fibers: Right atrium Right ventricle S. A. node • Left sympathetic fibers: Left atrium Left ventricle A. V. node

SYMPATHETIC STIMULATION: • Chronotropic effect – • Dromotropic effect – • Bathmotropic effect –

SYMPATHETIC STIMULATION: • Chronotropic effect – • Dromotropic effect – • Bathmotropic effect – • Inotropic effect – INNERVATION OF BLOOD VESSELS: Sympathetic fibers. Sympathetic cholinergic fibers. Parasympathetic fibers-

CARDIAC MUSCLE Intercalated disc Nucleus

CARDIAC MUSCLE Intercalated disc Nucleus

SARCOMERE OF CARDIAC MUSCLE Cistern Sarcolemma T - tubule Actin filament L - tubule

SARCOMERE OF CARDIAC MUSCLE Cistern Sarcolemma T - tubule Actin filament L - tubule Myosin filament Sarcomere I - band A - band I - band Z- line

Source of Calcium L - tubule Ca++ T- tubule Ca ++ Cisterns

Source of Calcium L - tubule Ca++ T- tubule Ca ++ Cisterns

SARCOTUBULAR SYSTEM Cardiac muscle Skeletal muscle Organization: Level of T tubules: Diameter of T

SARCOTUBULAR SYSTEM Cardiac muscle Skeletal muscle Organization: Level of T tubules: Diameter of T tubules: L tubules: Association of T & L tubules:

Contd- LEVEL OF T TUBULES Cardiac muscle Cisterns Z- line Myosin I-band A-band Skeletal

Contd- LEVEL OF T TUBULES Cardiac muscle Cisterns Z- line Myosin I-band A-band Skeletal muscle T-tubules Actin I-band A-band

Contd- TRIAD L-Tubules Ca ++ CARDIAC MUSCLE Cisterns T-tubules Ca ++ SKELETAL MUSCLE

Contd- TRIAD L-Tubules Ca ++ CARDIAC MUSCLE Cisterns T-tubules Ca ++ SKELETAL MUSCLE

DIFFERENCES BETWEEN MUSCLES: Smooth Fibres branched: Cross striations: Nucleus: Mitochondria: N-M junction: Sarcotubular system:

DIFFERENCES BETWEEN MUSCLES: Smooth Fibres branched: Cross striations: Nucleus: Mitochondria: N-M junction: Sarcotubular system: Nerve supply: Cardiac Skeletal

Contd- Smooth Pacemaker tissue: Autorhythmicity: Refractory period: Action potential: Cardiac Skeletal

Contd- Smooth Pacemaker tissue: Autorhythmicity: Refractory period: Action potential: Cardiac Skeletal

PACEMAKER & CONDUCTION TISSUES • Sinoatrial node – • Atrioventricular node – • Bundle

PACEMAKER & CONDUCTION TISSUES • Sinoatrial node – • Atrioventricular node – • Bundle of HIS – • Purkinje fibres -

SKELETON OF HEART • Fibrotendinous ring – Atria – Ventricle – • Impulse conduction

SKELETON OF HEART • Fibrotendinous ring – Atria – Ventricle – • Impulse conduction – • Link between Atria & Ventricle – • Interventricular septum -

Valve ring Chordae tendineae Papillary muscle

Valve ring Chordae tendineae Papillary muscle