Cardio Sense 3 D Introduction H Delingette Intermediate

Cardio. Sense 3 D Introduction H. Delingette Intermediate Evaluation of the Cardio. Sense 3 D Research Action

Agenda of the day Start End Topic Speaker 9 h 30 9 h 55 Introduction of Cardio. Sense 3 D ( with 5 mn questions) Hervé Delingette 9 h 55 10 h 25 10 h 55 11 h 10 11 h 40 12 h 10 12 h 30 Perspectives of Cardio. Sense 3 D ( with 5 mn questions) Miguel Fernandez 12 h 30 13 h 45 Lunch Break 13 h 45 16 h 00 Discussion with the evaluation committee All 16 h 00 17 h 00 Discussion within the evaluation committee Research Activity of the Asclepios Team within Cardio. Sense 3 D Hervé Delingette Maxime Sermesant ( with 5 mn questions) Research Activity of the Sisyphe Team within Cardio. Sense 3 D ( with 5 mn questions) Coffee Break Michel Sorine Research Activity of the Macs Team within Cardio. Sense 3 D Dominique Chapelle ( with 5 mn questions) Research Activity of the Reo Team within Cardio. Sense 3 D Jean-Frédéric Gerbeau ( with 5 mn questions)

Introduction to Cardio. Sense 3 D • Scientific Objectives and Positioning • Partnership and organization

What is Cardio. Sense 3 D ? An INRIA Large Initiative Action on cardiac modeling : • • • Started (officially) in May 2005 4 ans duration (evaluated after 2 years) Transversal to 4 INRIA project teams : – ASCLEPIOS (Medical Image Analysis and Simulation) N. Ayache – MACS (Biomechanics and Numerical Analysis) : D. Chapelle – REO (Fluid Mechanics) : J-F. Gerbeau – SISYPHE (Contrôle and Modeling) : M. Sorine • • Supervisor : H. Delingette, Co-Supervisor : M. Fernandez

Cardio. Sense 3 D Research Topics Therapy planning anatomy Personalization electro-physiology blood flow Diagnosis perfusion & metabolism Cardiac data solid mechanics Cardiac modeling Clinical applications

Objectives • Build a patient specific heart simulator • Estimate the parameters of this model from observations of the cardiac function, Propose models having a low number of parameters • Develop clinical applications (Cardiac Resynchronisation Therapy, radiofrequency ablation, . . ) .

State of the art Computational Cardiac Models • Electro. Physiology : Noble et al. (Oxford), anatomy S. Panfilov et al. , O. Dössel (Karlsruhe), Y. Rudy et al. (Wash. Univ. St Louis), Colli-Franzone (Univ. Pavia) perfusion & metabolism electro-physiology • Flow-Biomechanics : C. Peskin (NYU), Quarteroni (EPFL), … • Electro-mechanics : Peter Hunter et al. (Physiome project; Auckland); Andrew blood flow solid mechanics Cardiac modeling Mc. Culloch et al. (UCSD)

State of the art Cardiac Image Analysis (Geometrical approaches) • Elliott Mc. Veigh et al. (JHU+NIH) • D. Rueckert et al. (Imperial College) and R. Razavi et al. (KCL + Guy’s hospital) • Magnin et al (Creatis), Duncan et al (Yale), Axel and Metaxas (Rutgers & NYU), Frangi et al. (Univ. Pompeu Fabra), P. Shi (Hongkong Univ. ) Cardiac data

State of the art Therapy planning (Generic Models) • • • D. Noble (Oxford) A. Mc Culloch (UCSD) O. Dössel (U. Karlsruhe) & F. Sasche (U. Utah) Diagnosis Clinical

Positioning of Cardio. Sense 3 D • Integrate/Couple 4 physiological phenomena : Electrophysiology, Contraction/Relaxation Mechanics, Arterial Circulation, Perfusion • To propose models having a low number of parameters in order to estimate them from clinical data. • Develop clinical applications (CRT, RF Ablation) based on personalized models

Cardio. Sense 3 D : Academic / Clinical / Industrial Partnership Physiology/Control • Sisyphe/Sosso, INRIA Numerical Analysis • • Macs, INRIA Reo, INRIA Geometrica, INRIA Gamma, INRIA Univ. de Nantes Pzlen Univ. (Czech Rep. ) LIRMM (Montpellier) Imaging/Simulation • • • Asclepios, INRIA UCL / King’s College (London) Creatis, CNRS Clinical Sites • • Guy’s Hospital (London) NIH (Washington) HEGP, U 678 (Paris) Hopital Henri Mondor (Créteil) Sunnybrook Health Sciences Center In. Parys, Clinique George Bizet Hopital Bicêtre + Paris XI U. +INSERM (Paris) Industrial Partners • • • Philips Research France ELA Medical (Siemens)

First Circle Members of CS 3 D Two different INRIA Research Units : • Sophia-Antipolis • Rocquencourt

INRIA Support Recruitment of : • • P. Moireau (Détachement X-Corps des Telecoms) in 2005 4 Phd Thesis : – R. Chabiniok MD (Macs) from Sep. 2007 bourse Cordi – M. Astorino (Reo) from Janvier. 2007 bourse Cordi – F. Billet (Asclepios) from Oct 2006 – R. Djafri (Sisyphe) from 2007 • 3 Engineers : – M. Alba (Macs) 2005 -2006 Ingénieur Associé – E. Phe (Macs-REO) 2006 -2008 Ingénieur Associé – N. Toussaint (Asclepios) : 2006 -2008 Ingénieur Associé

External Support National Scholarship : • Ph. D of N. Zemzemi Philips Medical Systems Paris (Suresnes): • Ph. D of D. Lepiller (Asclepios) ELA Medical : • Post-doc of M. Boulakia (Reo) and Post-doc of G. Ebrard Siemens Corporate Research • Ph. D of JM Peyrat European Health e. Child • Ph. D of T. Mansi European RTN Hae. Model • Phd of N. Diniz Dos Santos Industrial contracts • Ph. D of M. Laleg and K. Djabella

Software Current Development based on 3 software packages : • • • Life. V (Reo) (www. lifev. org) for CFD and electrophysiology Open. FEM (Macs) (www-rocq. inria. fr/Open. FEM/ ) for FEM continuum mechanics Mips and Med. Inria (Asclepios) for medical image analysis + simple models for electrophysiology and soft tissue deformation (migration on SOFA) (www-sop. inria. fr/asclepios/software/Med. INRIA/) Software developed within Cardio. Sense 3 D : • • Cardio. Viz 3 D (Asclepios) Heartlab (Macs)

Dissemination Activity • “Digital Heart” DVD (20 mn) Auteurs scientifiques : Dominique Chapelle, Hervé Delingette, Miguel Fernandez, Philippe Moireau, Maxime Sermesant

Dissemination Activity • “Digital Heart” Movie • Public release of Software (Cardio. Viz 3 D) and database (DTI atlas) • Involvements in Conferences (NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News)

Dissemination Activity • “Digital Heart” DVD • Public release of Software (Cardio. Viz 3 D) and database (DTI atlas) • Involvements in Conferences (ISBI’ 07, NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News) • Cardio. Sense 3 D seminars with Paris V university

Dissemination Activity • “Digital Heart” DVD • Public release of Software (Cardio. Viz 3 D) and database (DTI atlas) • Involvements in Conferences (ISBI’ 07, NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News) • Cardio. Sense 3 D seminars with Paris V university • Organisation of workshops (summer school) and conferences (FIMH’ 09 in Nice) • Apple ARTS Award

Agenda of the day Start End Topic Speaker 9 h 30 9 h 55 Introduction of Cardio. Sense 3 D ( with 5 mn questions) Hervé Delingette 9 h 55 10 h 25 10 h 55 11 h 10 11 h 40 12 h 10 12 h 30 Perspectives of Cardio. Sense 3 D ( with 5 mn questions) Miguel Fernandez 12 h 30 13 h 45 Lunch Break 13 h 45 16 h 00 Discussion with the evaluation committee All 16 h 00 17 h 00 Discussion within the evaluation committee Research Activity of the Asclepios Team within Cardio. Sense 3 D Hervé Delingette Maxime Sermesant ( with 5 mn questions) Research Activity of the Sisyphe Team within Cardio. Sense 3 D ( with 5 mn questions) Coffee Break Michel Sorine Research Activity of the Macs Team within Cardio. Sense 3 D Dominique Chapelle ( with 5 mn questions) Research Activity of the Reo Team within Cardio. Sense 3 D Jean-Frédéric Gerbeau ( with 5 mn questions)

Cardio. Sense 3 D Research Topics Therapy planning anatomy Personalization electro-physiology blood flow Diagnosis perfusion & metabolism Cardiac data solid mechanics Cardiac modeling Clinical applications