Cardiac output and venous return Cardiac output The
- Slides: 20
Cardiac output and venous return
Cardiac output • The quantity of blood pumped into the aorta – Amount of blood that flows through the circulation – Most important factor in relation to the circulation
• Normal cardiac output – 5. 6 L/min in young men when resting • 10 -20 % less in women – Factors • Age • Level of body activity
• Cardiac index – Cardiac output per sq. m of body surface area • Body weight around 70 kg = 1. 7 sq. m body surface • Cardiac index = approximately 3 L/min/sq. m • Effects of age – Rapid increase (4 L/min/sq. m) at age 10 • Decline thereafter (2. 4 L/min/sq. m at age 80)
Venous return • Amount of blood flowing from the vein into the right atrium – Must be equal to cardiac output • Exception – Few heartbeats at a time for storage/removal of blood from heart and lungs
Control of cardiac output • Venous return – Primary controller • Peripheral factors – Not heart – Heart • Built-in mechanism to accommodate amount of blood that flows into the right atrium – Frank-Starlings law of the heart (pumping of blood) – Bainbridge reflex (heart rate)
• Venous return – sum of all blood flow from peripheral system – Cardiac output • sum of all local blood flow regulation • Controlled by factors that control local flow of blood
Cardiac output = sum of the various factors controlling local blood flow = sum of local blood flow = venous return
• Effects of total peripheral resistance – Variation in cardiac output under normal arterial pressure • Reciprocal of peripheral resistance • Increased peripheral resistance, decreased cardiac output – Ohm’s law
Plateau level in cardiac output • Amount of blood that a heart can pump out – Limited • Plateau around 13 L/min when normal – 2. 5 X above normal (5 L/min) – Heart has a capacity to pump 2. 5 X more blood than normal venous return before becoming a limiting factor – Abnormal condition • Hypereffective – Greater output • Hypoeffective – Lesser output
• Hypereffective heart – Nervous stimulation • Sympathetic stimulation and parasympathetic inhibition – Greatly increased heart rate (180 -200 beats/min) – Increased contractility of heart muscle by 2 X • Result – Raise in plateau level to 25 L/min after sympathetic stimulation
• Hypereffective heart – Heart hypertrophy • Increased workload – Increase in mass – Increase in contractile strength • Net results – Increased plateau output to 30 -40 L/min in marathon runners
• Pathologically high cardiac output – Cause • Chronically reduced total peripheral resistance – Not by excessive excitation of heart – Excessive excitation of heart • Sudden increase in cardiac output – Lasts only for a short time – Increased blood flow to tissue triggers vasoconstriction – Increased capillary filtration of fluid – Net result = decreased venous return
• Hypoeffective heart – Factors • • Nervous excitation inhibition Abnormal rhythm/rate of heart beat Valvular heart disease Hypertension Congenital heart disease Myocarditis Cardiac anoxia Damage to myocardium
• Low cardiac output – Abnormalities that decrease pumping effectiveness • Damage to cardiac muscles • Cause cardiac shock – Abnormalities that decrease venous return • Decreased blood volume • Acute venous dilation • Vessel obstruction – Cause circulatory shock • Reduced amount of nutrients being delivered
Role of nervous system • Maintenance of arterial blood pressure when cardiac output increases – Essential to achieve high cardiac output • Increased local blood flow via dilation of blood vessel – Increase arterial pressure during exercise • Increase cardiac output
- Systolic presure
- Tapvd
- What does peripheral resistance mean
- Refractory period cardiac
- Factors affecting cardiac output
- Cardiac output stroke volume
- Cardiac output and heart rate
- Homometric regulation of cardiac output
- Gittata cardiaca
- Map and tpr
- Cardiac output trained vs untrained
- Cardiac output trained vs untrained
- Cardiac output trained vs untrained
- Cardiac output trained vs untrained
- Cardiac output fick principle
- Intrinsic conduction system of the heart
- Fick principle cardiac output
- Normal co values
- Cardiac output
- Fick principle cardiac output
- Factors affecting stroke volume