Cancun December 7 2011 GA 2 LEN WAO

Cancun, December 7, 2011 GA 2 LEN WAO and Guidelines Prof. Giorgio Walter Canonica Allergy and Respiratory Diseases Department University of Genoa Past President 1°vice President

Guyatt GH ACP J Club 1991 Mar-Apr 20 years Compalati 09 2

From OBM to EBM Bousquet J. et al. , Allergy 2004

Background Principles Procedures Graphics Quality Conclusions metanalysis E. B. M Shekelle BMJ 1999; 318; 593 -596 Opinion Based Università degli Studi di Genova

ARIA Guidelines: Recommendations for Management of Allergic Rhinitis Check for asthma E. B. M Mild intermittent Mild persistent Moderate/ severe intermittent Intranasal corticosteroid Local chromone Leukotriene receptor antagonists Second-generation nonsedating H 1 -antihistamine Intranasal decongestant (<10 days) or oral decongestant Allergen and irritant avoidance Consider immunotherapy Bousquet et al. J Allergy Clin Immunol. 2001; 108(5 suppl): S 147. At: http: //www. whiar. org. Moderate/ severe persistent

EAACI/GA 2 LEN/EDF Guidelines for Management of Urticaria Zuberbier et al. Allergy. 2006; 61: 321 -331.

EAACI / WAO / GA 2 LEN / EDF Guidelines 3 rd International Consensus Meeting on Urticaria 2008

Management Zuberbier et al. Allergy. 2009; 64: 1427 -1443.

A general process in guidelines evolution E. B. M

Factors that influence the strength of a recommendation • Balance between desirable and undesirable effects • Quality of evidence • Patients’ values and preferences • Costs

Braido et al. Allergy 2010: DOI: 10. 1111/j. 1398 -9995. 2010. 02383. x.

Baiardini et al 2011

2012

Thank You canonica@unige. it