CAMPBELL BIOLOGY IN FOCUS Urry Cain Wasserman Minorsky
![CAMPBELL BIOLOGY IN FOCUS Urry • Cain • Wasserman • Minorsky • Jackson • CAMPBELL BIOLOGY IN FOCUS Urry • Cain • Wasserman • Minorsky • Jackson •](https://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-1.jpg)
CAMPBELL BIOLOGY IN FOCUS Urry • Cain • Wasserman • Minorsky • Jackson • Reece 5 Membrane Transport and Cell Signaling Lecture Presentations by Kathleen Fitzpatrick and Nicole Tunbridge © 2014 Pearson Education, Inc.
![Do now: Explain how the following structures provide fluidity to the cell membrane: § Do now: Explain how the following structures provide fluidity to the cell membrane: §](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-2.jpg)
Do now: Explain how the following structures provide fluidity to the cell membrane: § Unsaturated (double bonded) phospholipids § Cholesterol § Phospholipids are held together by weak bonds. How would high temperature affect these bonds? What about low temperatures? § Think: Which type of cell membrane would be more advantageous to an artic fish? § unsaturated phospholipids OR saturated phospholipids? § High levels of cholesterol or low levels of cholesterol?
![Figure 5. 3 Hydrophilic head WATER Hydrophobic tail © 2014 Pearson Education, Inc. Figure 5. 3 Hydrophilic head WATER Hydrophobic tail © 2014 Pearson Education, Inc.](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-3.jpg)
Figure 5. 3 Hydrophilic head WATER Hydrophobic tail © 2014 Pearson Education, Inc.
![Figure 5. 2 A) B Carbohydrate F EXTRACELLULAR SIDE OF MEMBRANE C Microfilaments of Figure 5. 2 A) B Carbohydrate F EXTRACELLULAR SIDE OF MEMBRANE C Microfilaments of](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-4.jpg)
Figure 5. 2 A) B Carbohydrate F EXTRACELLULAR SIDE OF MEMBRANE C Microfilaments of cytoskeleton D proteins E CYTOPLASMIC SIDE OF MEMBRANE © 2014 Pearson Education, Inc.
![Figure 5. 2 Fibers of extracellular matrix (ECM) Glycoprotein Carbohydrate Glycolipid EXTRACELLULAR SIDE OF Figure 5. 2 Fibers of extracellular matrix (ECM) Glycoprotein Carbohydrate Glycolipid EXTRACELLULAR SIDE OF](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-5.jpg)
Figure 5. 2 Fibers of extracellular matrix (ECM) Glycoprotein Carbohydrate Glycolipid EXTRACELLULAR SIDE OF MEMBRANE Cholesterol Microfilaments of cytoskeleton © 2014 Pearson Education, Inc. Peripheral proteins Integral protein CYTOPLASMIC SIDE OF MEMBRANE
![Figure 5. 1 © 2014 Pearson Education, Inc. Figure 5. 1 © 2014 Pearson Education, Inc.](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-6.jpg)
Figure 5. 1 © 2014 Pearson Education, Inc.
![Fluid Mosaic Model § Fluid: the phospholipids are capable of drift § Mosaic: the Fluid Mosaic Model § Fluid: the phospholipids are capable of drift § Mosaic: the](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-7.jpg)
Fluid Mosaic Model § Fluid: the phospholipids are capable of drift § Mosaic: the membrane is made up of many structures: phospholipids, proteins, cholesterol, glycoproteins, glycolipids © 2014 Pearson Education, Inc.
![Overview: Life at the Edge § The plasma membrane separates the living cell from Overview: Life at the Edge § The plasma membrane separates the living cell from](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-8.jpg)
Overview: Life at the Edge § The plasma membrane separates the living cell from its surroundings § The plasma membrane exhibits selective permeability, allowing some substances to cross it more easily than others Video: Membrane and Aquaporin © 2014 Pearson Education, Inc.
![How did scientists conclude that the C. M is fluid? Membrane proteins Mouse cell How did scientists conclude that the C. M is fluid? Membrane proteins Mouse cell](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-9.jpg)
How did scientists conclude that the C. M is fluid? Membrane proteins Mouse cell © 2014 Pearson Education, Inc. Human cell
![Figure 5. 4 -2 Results Membrane proteins Mouse cell © 2014 Pearson Education, Inc. Figure 5. 4 -2 Results Membrane proteins Mouse cell © 2014 Pearson Education, Inc.](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-10.jpg)
Figure 5. 4 -2 Results Membrane proteins Mouse cell © 2014 Pearson Education, Inc. Human cell Hybrid cell
![Figure 5. 4 -3 Results Membrane proteins Mouse cell © 2014 Pearson Education, Inc. Figure 5. 4 -3 Results Membrane proteins Mouse cell © 2014 Pearson Education, Inc.](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-11.jpg)
Figure 5. 4 -3 Results Membrane proteins Mouse cell © 2014 Pearson Education, Inc. Mixed proteins after 1 hour Human cell Hybrid cell
![The Fluidity of Membranes § Most of the lipids and some proteins in a The Fluidity of Membranes § Most of the lipids and some proteins in a](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-12.jpg)
The Fluidity of Membranes § Most of the lipids and some proteins in a membrane can shift about laterally § The lateral movement of phospholipids is rapid; proteins move more slowly § Some proteins move in a directed manner; others seem to be anchored in place © 2014 Pearson Education, Inc.
![Figure 5. 5 Fluid Unsaturated tails prevent packing. Viscous Saturated tails pack together. (a) Figure 5. 5 Fluid Unsaturated tails prevent packing. Viscous Saturated tails pack together. (a)](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-13.jpg)
Figure 5. 5 Fluid Unsaturated tails prevent packing. Viscous Saturated tails pack together. (a) Unsaturated versus saturated hydrocarbon tails (b) Cholesterol reduces membrane fluidity at moderate temperatures, but at low temperatures hinders solidification. Cholesterol © 2014 Pearson Education, Inc.
![§ As temperatures cool, membranes switch from a fluid state to a solid state § As temperatures cool, membranes switch from a fluid state to a solid state](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-14.jpg)
§ As temperatures cool, membranes switch from a fluid state to a solid state § The temperature at which a membrane solidifies depends on the types of lipids § A membrane remains fluid to a lower temperature if it is rich in phospholipids with unsaturated hydrocarbon tails § At warm temperatures (such as 37 o. C), cholesterol restrains movement of phospholipids § At cool temperatures, it maintains fluidity by preventing tight packing © 2014 Pearson Education, Inc.
![Membrane Proteins and Their Functions § Integral proteins penetrate the hydrophobic interior of the Membrane Proteins and Their Functions § Integral proteins penetrate the hydrophobic interior of the](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-15.jpg)
Membrane Proteins and Their Functions § Integral proteins penetrate the hydrophobic interior of the lipid bilayer § Integral proteins that span the membrane are called transmembrane proteins § Peripheral proteins are loosely bound to the surface of the membrane © 2014 Pearson Education, Inc.
![Figure 5. 6 N-terminus helix C-terminus © 2014 Pearson Education, Inc. EXTRACELLULAR SIDE CYTOPLASMIC Figure 5. 6 N-terminus helix C-terminus © 2014 Pearson Education, Inc. EXTRACELLULAR SIDE CYTOPLASMIC](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-16.jpg)
Figure 5. 6 N-terminus helix C-terminus © 2014 Pearson Education, Inc. EXTRACELLULAR SIDE CYTOPLASMIC SIDE
![Figure 5. 7 Enzymes ATP (a) Transport (b) Enzymatic activity (c) Attachment to the Figure 5. 7 Enzymes ATP (a) Transport (b) Enzymatic activity (c) Attachment to the](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-17.jpg)
Figure 5. 7 Enzymes ATP (a) Transport (b) Enzymatic activity (c) Attachment to the cytoskeleton and extracellular matrix (ECM) Signaling molecule Receptor Glycoprotein (d) Cell-cell recognition © 2014 Pearson Education, Inc. (e) Intercellular joining (f) Signal transduction
![The Role of Membrane Carbohydrates in Cell-Cell Recognition § Cells recognize each other by The Role of Membrane Carbohydrates in Cell-Cell Recognition § Cells recognize each other by](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-18.jpg)
The Role of Membrane Carbohydrates in Cell-Cell Recognition § Cells recognize each other by binding to surface molecules, often containing carbohydrates, on the extracellular surface of the plasma membrane § Glycolipids- carbohydrates to lipids § Ex: Cell signaling § Glycoproteins- carbohydrates to proteins § Ex: antibody recognition § Carbohydrates on the external side of the plasma membrane vary among species, individuals, and even cell types in an individual © 2014 Pearson Education, Inc.
![Synthesis and Sidedness of Membranes § Membranes have distinct inside and outside faces § Synthesis and Sidedness of Membranes § Membranes have distinct inside and outside faces §](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-19.jpg)
Synthesis and Sidedness of Membranes § Membranes have distinct inside and outside faces § The asymmetrical distribution of proteins, lipids, and associated carbohydrates in the plasma membrane is determined when the membrane is built by the ER and Golgi apparatus © 2014 Pearson Education, Inc.
![Figure 5. 8 Transmembrane glycoproteins Secretory protein Golgi apparatus Vesicle ER ER lumen Glycolipid Figure 5. 8 Transmembrane glycoproteins Secretory protein Golgi apparatus Vesicle ER ER lumen Glycolipid](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-20.jpg)
Figure 5. 8 Transmembrane glycoproteins Secretory protein Golgi apparatus Vesicle ER ER lumen Glycolipid Plasma membrane: Cytoplasmic face Extracellular face Transmembrane glycoprotein Secreted protein Membrane glycolipid © 2014 Pearson Education, Inc.
![CONCEPT 5. 2: Membrane structure results in selective permeability § A cell must regulate CONCEPT 5. 2: Membrane structure results in selective permeability § A cell must regulate](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-21.jpg)
CONCEPT 5. 2: Membrane structure results in selective permeability § A cell must regulate transport of substances across cellular boundaries § Plasma membranes are selectively permeable, regulating the cell’s molecular traffic § Small, polar ions (K+) § Large polar (sugar) § Small, polar (water) § Nonpolar, small (carbon dioxide) © 2014 Pearson Education, Inc.
![Substances are able to move through a membrane, but what determines direction? Diffusion is Substances are able to move through a membrane, but what determines direction? Diffusion is](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-22.jpg)
Substances are able to move through a membrane, but what determines direction? Diffusion is the tendency for molecules to spread out evenly into the available space Animation: Diffusion © 2014 Pearson Education, Inc.
![Diffusion § Substances diffuse down their concentration gradient (high to low) § No work Diffusion § Substances diffuse down their concentration gradient (high to low) § No work](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-23.jpg)
Diffusion § Substances diffuse down their concentration gradient (high to low) § No work must be done to move substances down the concentration gradient (spontaneous) § Also known as Passive Transport © 2014 Pearson Education, Inc.
![How do polar molecules diffuse through a membrane? § In facilitated diffusion, transport proteins How do polar molecules diffuse through a membrane? § In facilitated diffusion, transport proteins](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-24.jpg)
How do polar molecules diffuse through a membrane? § In facilitated diffusion, transport proteins speed the passive movement of molecules across the plasma membrane § How is facilitated diffusion similar to simple diffusion? § How is facilitated diffusion different from simple diffusion? Video: Aquaporins Video: Membrane and Aquaporin © 2014 Pearson Education, Inc.
![Transport Proteins allow passage of hydrophilic substances/polar substances across the membrane § channel proteins Transport Proteins allow passage of hydrophilic substances/polar substances across the membrane § channel proteins](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-25.jpg)
Transport Proteins allow passage of hydrophilic substances/polar substances across the membrane § channel proteins § have a hydrophilic channel that certain molecules or ions can use as a tunnel § Channel proteins called aquaporins facilitate the passage of water © 2014 Pearson Education, Inc. § carrier proteins § bind to molecules and change shape to shuttle them across the membrane
![Effects of Osmosis on Water Balance § Osmosis is the facilitated diffusion of free Effects of Osmosis on Water Balance § Osmosis is the facilitated diffusion of free](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-26.jpg)
Effects of Osmosis on Water Balance § Osmosis is the facilitated diffusion of free water across a selectively permeable membrane § Water diffuses across a membrane from the region of lower solute concentration to the region of higher solute concentration until the solute concentration is equal on both sides Animation: Membrane Selectivity Animation: Osmosis © 2014 Pearson Education, Inc.
![Do now: §Is water a polar or nonpolar molecule? Explain. §If water must diffuse Do now: §Is water a polar or nonpolar molecule? Explain. §If water must diffuse](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-27.jpg)
Do now: §Is water a polar or nonpolar molecule? Explain. §If water must diffuse what type of transport will it utilize? Explain §In which type of solution would a cell gain mass – hypertonic, hypotonic or isotonic solution? Explain.
![Figure 5. 10 _______ Sugar molecule ____ Selectively permeable membrane Osmosis © 2014 Pearson Figure 5. 10 _______ Sugar molecule ____ Selectively permeable membrane Osmosis © 2014 Pearson](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-28.jpg)
Figure 5. 10 _______ Sugar molecule ____ Selectively permeable membrane Osmosis © 2014 Pearson Education, Inc. More similar concentrations of solute
![Figure 5. 10 Lower concentration of solute (sugar) Higher concentration of solute Sugar molecule Figure 5. 10 Lower concentration of solute (sugar) Higher concentration of solute Sugar molecule](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-29.jpg)
Figure 5. 10 Lower concentration of solute (sugar) Higher concentration of solute Sugar molecule H 2 O Selectively permeable membrane Osmosis © 2014 Pearson Education, Inc. More similar concentrations of solute
![Figure 5. 11 Isotonic Hypotonic Animal cell H 2 O Lysed Cell wall H Figure 5. 11 Isotonic Hypotonic Animal cell H 2 O Lysed Cell wall H](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-30.jpg)
Figure 5. 11 Isotonic Hypotonic Animal cell H 2 O Lysed Cell wall H 2 O Shriveled Normal H 2 O Plant cell H 2 O Hypertonic Turgid (normal) © 2014 Pearson Education, Inc. Flaccid Plasmolyzed
![Water Balance of Cells Without Walls § Tonicity is the ability of a surrounding Water Balance of Cells Without Walls § Tonicity is the ability of a surrounding](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-31.jpg)
Water Balance of Cells Without Walls § Tonicity is the ability of a surrounding solution to cause a cell to gain or lose water § Isotonic solution: Solute concentration is the same as inside the cell; no net water movement across the plasma membrane § Hypertonic solution: Solute concentration is greater than that inside the cell; cell loses water § Hypotonic solution: Solute concentration is less than that inside the cell; cell gains water Video: Turgid Elodea © 2014 Pearson Education, Inc.
![§ Hypertonic or hypotonic environments create osmotic problems for organisms § Osmoregulation, the control § Hypertonic or hypotonic environments create osmotic problems for organisms § Osmoregulation, the control](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-32.jpg)
§ Hypertonic or hypotonic environments create osmotic problems for organisms § Osmoregulation, the control of solute concentrations and water balance, is a necessary adaptation for life in such environments § Problem: The protist Paramecium caudatum, lives in a hypotonic external environment § Solution: has a contractile vacuole that can pump excess water out of the cell Video: Chlamydomonas Video: Paramecium Vacuole © 2014 Pearson Education, Inc.
![Figure 5. 12 Contractile vacuole © 2014 Pearson Education, Inc. 50 m Figure 5. 12 Contractile vacuole © 2014 Pearson Education, Inc. 50 m](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-33.jpg)
Figure 5. 12 Contractile vacuole © 2014 Pearson Education, Inc. 50 m
![Active Transport § Active transport moves substances against their concentration gradients (L to H) Active Transport § Active transport moves substances against their concentration gradients (L to H)](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-34.jpg)
Active Transport § Active transport moves substances against their concentration gradients (L to H) § requires energy, in the form of ATP § Active transport allows cells to maintain concentration gradients that differ from their surroundings § The sodium-potassium pump is one type of active transport system Animation: Active Transport Video: Sodium-Potassium Pump Video: Membrane Transport © 2014 Pearson Education, Inc.
![Figure 5. 14 EXTRACELLULAR FLUID 1 © 2014 Pearson Education, Inc. CYTOPLASM [Na ] Figure 5. 14 EXTRACELLULAR FLUID 1 © 2014 Pearson Education, Inc. CYTOPLASM [Na ]](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-35.jpg)
Figure 5. 14 EXTRACELLULAR FLUID 1 © 2014 Pearson Education, Inc. CYTOPLASM [Na ] high [K ] low [Na ] low [K ] high 2 6 3 5 4 ADP
![Figure 5. 14 a EXTRACELLULAR [Na ] high FLUID [K ] low CYTOPLASM [Na Figure 5. 14 a EXTRACELLULAR [Na ] high FLUID [K ] low CYTOPLASM [Na](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-36.jpg)
Figure 5. 14 a EXTRACELLULAR [Na ] high FLUID [K ] low CYTOPLASM [Na ] low [K ] high 1 Cytoplasmic Na binds to the sodium-potassium pump. The affinity for Na is high when the protein has this shape. © 2014 Pearson Education, Inc. ADP 2 Na binding stimulates phosphorylation by ATP.
![Figure 5. 14 b 3 Phosphorylation leads to a change in protein shape, reducing Figure 5. 14 b 3 Phosphorylation leads to a change in protein shape, reducing](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-37.jpg)
Figure 5. 14 b 3 Phosphorylation leads to a change in protein shape, reducing its affinity for Na , which is released outside. © 2014 Pearson Education, Inc. 4 The new shape has a high affinity for K , which binds on the extracellular side and triggers release of the phosphate group.
![Figure 5. 14 c 5 Loss of the phosphate group restores the protein’s original Figure 5. 14 c 5 Loss of the phosphate group restores the protein’s original](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-38.jpg)
Figure 5. 14 c 5 Loss of the phosphate group restores the protein’s original shape, which has a lower affinity for K. © 2014 Pearson Education, Inc. 6 K is released; affinity for Na is high again, and the cycle repeats.
![Figure 5. 15 _____ transport A © 2014 Pearson Education, Inc. _______ transport B Figure 5. 15 _____ transport A © 2014 Pearson Education, Inc. _______ transport B](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-39.jpg)
Figure 5. 15 _____ transport A © 2014 Pearson Education, Inc. _______ transport B
![Figure 5. 15 Passive transport Diffusion © 2014 Pearson Education, Inc. Active transport Facilitated Figure 5. 15 Passive transport Diffusion © 2014 Pearson Education, Inc. Active transport Facilitated](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-40.jpg)
Figure 5. 15 Passive transport Diffusion © 2014 Pearson Education, Inc. Active transport Facilitated diffusion
![Bulk Transport § Small solutes and water enter or leave the cell through the Bulk Transport § Small solutes and water enter or leave the cell through the](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-41.jpg)
Bulk Transport § Small solutes and water enter or leave the cell through the lipid bilayer or by means of transport proteins § How can large molecules cross? § Vesicles § Requires energy § Two Types of bulk transport: § Endocytosis § Exocytosis © 2014 Pearson Education, Inc.
![Exocytosis § In exocytosis, transport vesicles migrate to the membrane, fuse with it, and Exocytosis § In exocytosis, transport vesicles migrate to the membrane, fuse with it, and](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-42.jpg)
Exocytosis § In exocytosis, transport vesicles migrate to the membrane, fuse with it, and release their contents § Many secretory cells use exocytosis to export products © 2014 Pearson Education, Inc.
![Endocytosis § In endocytosis, the cell takes in molecules and particulate matter by forming Endocytosis § In endocytosis, the cell takes in molecules and particulate matter by forming](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-43.jpg)
Endocytosis § In endocytosis, the cell takes in molecules and particulate matter by forming new vesicles from the plasma membrane § Endocytosis is a reversal of exocytosis, involving different proteins § There are three types of endocytosis § Phagocytosis (“cellular eating”) § Pinocytosis (“cellular drinking”) § Receptor-mediated endocytosis © 2014 Pearson Education, Inc.
![Endocytosis Animation: Exocytosis Endocytosis Introduction Animation: Exocytosis Animation: Phagocytosis Video: Phagocytosis Animation: Pinocytosis Animation: Endocytosis Animation: Exocytosis Endocytosis Introduction Animation: Exocytosis Animation: Phagocytosis Video: Phagocytosis Animation: Pinocytosis Animation:](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-44.jpg)
Endocytosis Animation: Exocytosis Endocytosis Introduction Animation: Exocytosis Animation: Phagocytosis Video: Phagocytosis Animation: Pinocytosis Animation: Receptor-Mediated Endocytosis © 2014 Pearson Education, Inc.
![Figure 5. 18 Phagocytosis Pinocytosis Receptor-Mediated Endocytosis EXTRACELLULAR FLUID Solutes Pseudopodium Plasma membrane Coat Figure 5. 18 Phagocytosis Pinocytosis Receptor-Mediated Endocytosis EXTRACELLULAR FLUID Solutes Pseudopodium Plasma membrane Coat](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-45.jpg)
Figure 5. 18 Phagocytosis Pinocytosis Receptor-Mediated Endocytosis EXTRACELLULAR FLUID Solutes Pseudopodium Plasma membrane Coat protein “Food” or other particle Food vacuole CYTOPLASM © 2014 Pearson Education, Inc. Coated pit Coated vesicle Receptor
![Figure 5. 18 a Phagocytosis Pseudopodium of amoeba EXTRACELLULAR FLUID Solutes Bacterium Food vacuole Figure 5. 18 a Phagocytosis Pseudopodium of amoeba EXTRACELLULAR FLUID Solutes Bacterium Food vacuole](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-46.jpg)
Figure 5. 18 a Phagocytosis Pseudopodium of amoeba EXTRACELLULAR FLUID Solutes Bacterium Food vacuole 1 m Pseudopodium “Food” or other particle An amoeba engulfing a bacterium via phagocytosis (TEM) Food vacuole CYTOPLASM © 2014 Pearson Education, Inc.
![Pinocytosis Plasma membrane 0. 25 m Figure 5. 18 b Pinocytotic vesicles forming (TEMs) Pinocytosis Plasma membrane 0. 25 m Figure 5. 18 b Pinocytotic vesicles forming (TEMs)](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-47.jpg)
Pinocytosis Plasma membrane 0. 25 m Figure 5. 18 b Pinocytotic vesicles forming (TEMs) Coat protein Coated pit Coated vesicle © 2014 Pearson Education, Inc.
![Figure 5. 18 c Receptor-Mediated Endocytosis Coat protein 0. 25 m Plasma membrane Top: Figure 5. 18 c Receptor-Mediated Endocytosis Coat protein 0. 25 m Plasma membrane Top:](http://slidetodoc.com/presentation_image_h/18972d5dd606b9c504dcec86554a6878/image-48.jpg)
Figure 5. 18 c Receptor-Mediated Endocytosis Coat protein 0. 25 m Plasma membrane Top: A coated pit Bottom: A coated vesicle forming during receptormediated endocytosis (TEMs) © 2014 Pearson Education, Inc. Receptor
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