Burkitt Lymphoma Rob Corbett NCCN Christchurch Burkitt Lymphoma

Burkitt Lymphoma Rob Corbett NCCN Christchurch

Burkitt Lymphoma • Non-Hodgkin lymphoma or Mature B cell lymphoma • Very rapid growth! • Diverse / multiofocal presentations • 3 types: • Endemic • Sporadic • Immune-deficiency • Spread to BM and CNS • Very sensitive to chemotherapy • Endemic: • EBV + malaria • Found: • Tropical Africa • PNG / Solomons • 30 -50% of childhood cancers • 6 yrs >males • Sites • • Abdomen Orbit/jaw Both Paraspinal

Burkitt Lymphoma • Sporadic • Found • Europe • N Amercia • Australasia • Peak age sl older • Marked male predominance • Abdominal disease, then head and neck • Both Endemic and Sporadic: • Stage I/II 20% • Stage III 65% • Stage IV 15%

Burkitt Lymphoma – Patient Journey • PNG • 5 yo male • Ill for 3 weeks with abdominal distention and wt loss • O/E • Unwell uncomfortable • Cachetic pale • Abdomen “full” and tense without discreet masses • Radiology • US – hypoechoic masses • CT • Diagnosis • Fine needle aspirate • Sample fluid • “starry sky” • Staging • CSF • BMs

Burkitt Lymphoma – Patient Journey • Supportive care vital • • Pain control Infection Nutrition Tumour lysis syndrome – critical • Treatment – depends on resources

Patient Journey • 12 month EFS • • • Overall 61% Stage I 100% Stage II 85% Stage III 60% Stage IV 27%

Burkitt Lymphoma – Pacific Is