BRUCELLOSIS UNDER SUPERVISION OF PROF SHEREIN SAEID ABDELGAYED
BRUCELLOSIS UNDER SUPERVISION OF PROF. /SHEREIN SAEID ABDELGAYED
BRUCELLOSIS Brucellosis, a bacterial disease caused by members of the genus Brucella, remains one of the most common zoonotic diseases worldwide, also cause abortion which is common and rate varies from 30%-80%. So this disease is very dangerous as it can affect man and also cause large economic losses by decreasing milk yield and aborted fetus.
BRUCELLOSIS Abortio n Brucell a Spp. Host domestic Ans & man
SYNONYMS A-in human B-in animals Jones disease Bang’s disease Malta fever Slinking of calves Mediterranean fever Contagious abortion Undulant fever Bruce septicemia
Points of interest v. Define v. Causative agent v. Route of infection v. Pathogenesis v. Microscopic examination v. Macroscopic examination
keyword MIND MAPPING OF BRUCELLOSIS intracellular Reticuloendothe il cells q[spleen-Lymph nodesliver] Genital system q. Female ; mammary gland, it’s L. N, pregnant uterus. q. Male; testis, accessory glands [S. Vesicle, Epididymis & Brucella chronic q. Persist for long time or lifelong. q. M. O live inside macrophages. qlocalization of the M. O in any organ causes granuloma formation.
Define Brucellosis It is a chronic bacterial infection affect domestic animals and man. it is characterized by abortion. Cause Brucella species, which is gram –ve bacilli and intracellular. B. melitensis B. abortus B. suis Goat cattle pig B. ovis sheep
ROUTE OF INFECTION q. Ingestion of raw milk q. Through conjunctiva q. Intact or broken skin q. By coitus
4 Brucella PATHOGENESIS Regional L. N Acute lymphadenitis L. N is enlarged, hyperplastic , sinuses are filled w’ NQ and plasma cells. Localization in organs others Synovial structures • Arthritis • Purulent tendovaginitis Genital system Rich in erythritol • Help growth of M. O Female blood Reticloendotheil cells bacteremia Liver-spleen-L. N M. O Muliplicate epitheloid cells wherever the org. is localized, a granuloma develops? N. B Th. du ct
(continue) pathogenesis Localization in genital organs Female Mammary gland Fetus Pregnant uterus placenta male Respiratory system Testis (Seminal. vesc + prostate) Intracellular edema + necrosis Chronic mastitis Carancle Abortion cotyledon+chorionic villi Retained placenta Accessory gland Bronchopneumonia orchitis Seminalvesiclitis prostitis
ABORTION IN CATTLE In 7 th &8 th months of gestation(still birth abortion) In minor severity In severe cases Premature birth The calf may be delivered normally and be viable or non viable
PM LESIONS -Brucella abortusinfected aborted fetus with an acute diffuse severe fibrinous pleuritis -Edema in intercotyledonary placenta -increased opacity -leathery texture -light brown exudate -necrosis of cotyledon -Uterus from a Brucella abortus-infected cow immediately after abortion
MACRO: Retalined placenta due to: inflammatory enlargement of terminal portions of maternal villi
Fibrinous bronchopneumonia with necrosis
BANG’S DISEASE
Brucella spp. causes orchitis Orchitis characterized by: -foci of necrosis in the testicular parenchyma coalesce to produce total testicular necrosis necrotic parenchyma liquefies into pus surrounded by CT capsule -
LESIONS IN BULL Ø Chronic epididymitis in a ram due to Brucella ovis infection Although it appears that there is purulent exudate draining from the cut surface, the figure shows epididymal duct contents (mostly sperm) draining from a spermatic granuloma
Asymmetrical epididymal tails from a ram due to Brucella ovis induced unilateral chronic epididymitis
COMPLICATIONS: • Most common – Arthritis, spondylitis, epididymo-orchitis, chronic fatigue -Infertility • Neurological – 5% of cases • Other – Ocular, cardiovascular, additional organs and tissues
Thanks for attention Ø Presented by: Sabah Ali Salma Medhat
- Slides: 26