Breakdown Problems This powerpoint tutorial is best when

Breakdown Problems • This powerpoint tutorial is best when it is downloaded and run using the presentation mode in powerpoint.

Breakdown Summary • Aldol 3 -hydroxycarbonyl 1. ) Break 2, 3 bond 2. ) Carbon 2 gets a H 3. ) Carbon 3 becomes a carbonyl • Aldol a, b unsaturated carbonyl 1. ) Break 2, 3 bond 2. ) Carbon 2 gets a H 3. ) Carbon 3 becomes a carbonyl

Breakdown Summary • Claisen 1, 3 dicarbonyl 1. ) Break 2, 3 bond 2. ) Carbon 2 gets a H 3. ) Carbon 3 gets an OR group (To be a Claisen product, carbon two needs an H) • Michael 1, 5 dicarbonyl 1. ) Break 2, 3 bond 2. ) Carbon 2 gets a H 3. ) Carbons 3 and 4 get a new pi bond between them (Watch out for 5 bonded carbons)

Problem 1 3 2 1 A. Aldol B. Michael C. Claisen

Problem 2 2 3 1 5 4 A. Aldol B. Michael C. Claisen

Problem 3 3 1 2 A. Aldol B. Michael C. Claisen

4 5 3 Problem 4 2 1 A. Aldol B. Michael C. Claisen

Problem 5 2 3 1 A. Aldol B. Michael C. Claisen

Problem 6 2 1 3 2 1 A. Aldol B. Michael C. Claisen

Problem 7 1 2 3 4 5 A. Aldol B. Michael C. Claisen

Problem 8 1 3 2 A. Aldol B. Michael C. Claisen

Problem 9 2 3 1 A. Aldol B. Michael C. Claisen

Problem 10 1 3 2 A. Aldol B. Michael C. Claisen

Problem 11 1 2 3 A. Aldol B. Michael C. Claisen

Problem 12 1 3 2 A. Aldol B. Michael C. Claisen

Problem 13 1 2 3 A. Aldol B. Michael C. Claisen

Problem 14 3 5 4 2 1 A. Aldol B. Michael C. Claisen

Problem 15 1 3 2 A. Aldol B. Michael C. Claisen

Problem 16 3 2 1 A. Aldol B. Michael C. Claisen

Problem 17 4 3 5 2 1 A. Aldol B. Michael C. Claisen

Problem 18 3 2 1 A. Aldol B. Michael C. Claisen

Problem 19 1 3 2 A. Aldol B. Michael C. Claisen

Problem 20 3 2 1 A. Aldol B. Michael C. Claisen

Problem 21 4 3 1 5 2 A. Aldol B. Michael C. Claisen

Problem 22 2 1 3 A. Aldol B. Michael C. Claisen

Problem 23 4 3 2 5 1 A. Aldol B. Michael C. Claisen

Problem 24 3 1 2 A. Aldol B. Michael C. Claisen

Problem 25 1 3 2 A. Aldol B. Michael C. Claisen

Problem 26 3 1 2 Incorrect numbering below: Carbon 2 needs a H for the Claisen Condensation A. Aldol B. Michael C. Claisen

Problem 27 1 2 3 4 5 A. Aldol B. Michael C. Claisen

Problem 28 3 2 1 A. Aldol B. Michael C. Claisen